11 hasil untuk "Helmut Popper"
Menampilkan 1–11 · 0,25 detik · RSS
-
Artikel Jurnal
Role of dendritic cells in immunologic and smoking-induced lung diseases
Dendritic cells (DCs) are part of the specific and innate immune system and present antigens for lymphocytes but also regulate the actions of cells of the innate immune system such as eosinophilic and neutrophilic granulocytes. There are several types of DCs, which might have opposite functions…
-
Artikel Jurnal
Diagnosis and Molecular Profiles of Large Cell Neuroendocrine Carcinoma With Potential Targets for Therapy
Large cell neuroendocrine carcinoma (LCNEC) together with small cell carcinoma (SCLC) and typical and atypical carcinoids form the group of pulmonary neuroendocrine tumors. LCNEC and SCLC are high-grade carcinomas. Although both can be found outside the thoracic cavity, they are most common in the…
-
Artikel Jurnal
Monocytoid dendritic cells might be a specific marker for lung involvement in dermatomyositis
Abstract Dermatomyositis (DM) is a rare autoimmune disease leading to inflammatory and degenerative changes affecting skin and muscles. Interstitial lung disease is a major risk factor for morbidity and mortality in DM. The precise immune mechanism underlying DM, particularly in the context of lung…
-
Artikel Jurnal
Bulk tumour cell migration in lung carcinomas might be more common than epithelial-mesenchymal transition and be differently regulated
Abstract Background Epithelial-to-mesenchymal transition (EMT) is one mechanism of carcinoma migration, while complex tumour migration or bulk migration is another - best demontrated by tumour cells invading blood vessels. Methods Thirty cases of non-small cell lung carcinomas were used for…
-
Artikel Jurnal
Applicability of pan-TRK immunohistochemistry for identification of NTRK fusions in lung carcinoma
Abstract In the last two decades, various therapies have been introduced for lung carcinoma patients, including tyrosine-kinase inhibitors for different mutations. While some of them are specific to specific tumor types, others, like NTRK1–3 fusions, are found in various solid tumors. The…
-
Artikel Jurnal
Difficult diagnosis and rare morphology of lymphangioleiomyomatosis with giant cysts
We report on a 32-year-old woman with a second manifestation of a tension pneumothorax two weeks after drainage therapy. The chest CT-scan revealed multiple large bilateral pulmonary cysts. She underwent minimally invasive wedge resection and pleurectomy for treatment. The extensive histologic…
-
Artikel Jurnal
Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures
Abstract Background Small cell lung cancer (SCLC) is usually diagnosed in the advanced stage. It has a very poor prognosis, with no advancements in therapy in the last few decades. A recent phase 1 clinical study, using an antibody-drug conjugate directed against DLL3, showed promising results. A…
-
Artikel Jurnal Teks lengkap
Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling…
-
Artikel Jurnal Teks lengkap
Multicenter Phase II Study Evaluating Two Cycles of Docetaxel, Cisplatin and Cetuximab as Induction Regimen Prior to Surgery in Chemotherapy-Naive Patients with NSCLC Stage IB-IIIA (INN06-Study)
Background: Different strategies for neoadjuvant chemotherapy in patients with early stage NSCLC have already been evaluated. The aim of this study was to evaluate the tolerability and efficacy of a chemoimmunotherapy when limited to two cycles. Methods: Between 01/2007 and 03/2010 41 patients with…
Juga tersedia di: DOAJ
-
Artikel Jurnal
Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids
Abstract Background Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis, divides…