21 results for "Jerry Lin"
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Journal Article
The genetic basis of grape and wine aroma
Abstract The grape is one of the oldest and most important horticultural crops. Grape and wine aroma has long been of cultural and scientific interest. The diverse compound classes comprising aroma result from multiple biosynthetic pathways. Only fairly recently have researchers begun to elucidate…
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A NEURAL FUZZY SYSTEM APPROACH TO ASSESSING THE RISK OF EARNINGS RESTATEMENTS
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Protocol to characterize mouse dural mast cells by flow cytometry and immunofluorescence
…details on the use and execution of this protocol, please refer to Lin et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
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Data-driven integration kernels for interpretable nonlocal operator learning
Machine learning models can represent climate processes that are nonlocal in horizontal space, height, and time, often by combining information across these dimensions in highly nonlinear ways. While this can improve predictive skill, it makes learned relationships difficult to interpret and prone…
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Investigating casino event management integration: The case of East and South Asia casinos
The aim of this study is to investigate the gap of event management in East and South Asia’s casinos throughout the information provided by casinos on their websites. Main objective is to identify the differences and similarities of event holding in East and South Asia’s casinos and suggest future…
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Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapies
Immunocompromised individuals, including multiple sclerosis (MS) patients on certain immunotherapy treatments, are considered susceptible to complications from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and specific vaccination regimens have been recommended for suitable…
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Stable Machine‐Learning Parameterization of Subgrid Processes in a Comprehensive Atmospheric Model Learned From Embedded Convection‐Permitting Simulations
Abstract Modern climate projections often suffer from inadequate spatial and temporal resolution due to computational limitations, resulting in inaccurate representations of sub‐grid processes. A promising technique to address this is the multiscale modeling framework (MMF), which embeds a…
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The role of multivitamins and minerals (MVM) supplementation in dementia risk reduction for older people in Taiwan: Insights from a population health and economic model
Objectives: To estimate the potential health and economic impact of regular multivitamin and mineral (MVM) supplementation in reducing dementia risk among Taiwanese adults aged ≥ 60 years old. Methods: A population-based health economic model was developed to project dementia-related health and…
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Leveraging foundation models to dissect the genetic basis of cluster compactness and yield in grapevine
Abstract Grape cluster compactness is a key trait that influences fruit quality, yield, and disease susceptibility. Understanding the genetic basis of this trait is essential for optimizing vineyard management and improving grapevine cultivars. In this study, we performed quantitative trait locus…
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Structure‐Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology
Abstract Histone deacetylase 6 (HDAC6) is one of the key histone deacetylases (HDACs) that regulates various cellular functions including clearance of misfolded protein and immunological responses. Considerable evidence suggests that HDAC6 is closely related to amyloid and tau pathology, the two…
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Humoral and cellular responses to repeated COVID-19 exposure in multiple sclerosis patients receiving B-cell depleting therapies: a single-center, one-year, prospective study
Multiple sclerosis patients treated with anti-CD20 therapy (aCD20-MS) are considered especially vulnerable to complications from SARS-CoV-2 infection due to severe B-cell depletion with limited viral antigen-specific immunoglobulin production. Therefore, multiple vaccine doses as part of the…
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Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice
Emerging evidence suggests that peripheral immune cells contribute to Alzheimer’s disease (AD) neuropathogenesis. Among these, mast cells are known for their functions in allergic reactions and neuroinflammation; however, little is known about their role in AD. Here, we crossed 5XFAD mice with mast…
Also available at: DOAJ
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Optimizing animal models of autoimmune encephalitis using active immunization
Background and objectivesEncephalitis is a devastating neurologic disorder with high morbidity and mortality. Autoimmune causes are roughly as common as infectious ones. N-methyl-D-aspartic acid receptor (NMDAR) encephalitis (NMDARE), characterized by serum and/or spinal fluid NMDAR antibodies, is…
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An Implementation of Trust Chain Framework with Hierarchical Content Identifier Mechanism by Using Blockchain Technology
Advances in information technology (IT) and operation technology (OT) accelerate the development of manufacturing systems (MS) consisting of integrated circuits (ICs), modules, and systems, toward Industry 4.0. However, the existing MS does not support comprehensive identity forensics for the whole…
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The genetic basis of sex determination in grapes
Grapevine is one of a few ancestrally dioecious crops that are reverted to hermaphroditism during domestication. Here, the authors identify candidate genes related to male- and female-sterility in grapes and describe the genetic process that led to hermaphroditism during domestication.
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Infiltrating CD8(+) T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer’s disease (AD) pathology. To examine these interactions, in the present study we developed a three-dimensional human neuroimmune axis model comprising stem cell-derived…
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The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function
We previously reported that T96K is a gain-of-function mutation in TREM2 based on its ability to increase ligand-dependent activation. Here, we show that TREM2(T96K) increases risk for Alzheimer’s disease (AD) in a whole-genome sequencing dataset comprised of family-based and case-control samples…