37 results for "Li-Chung Chiu"

Case Report: High-dose steroid and IVIG successful treatment in a case of COVID-19-associated autoimmune encephalitis: a literature review

Chi-Hung Liu; Li-Chung Chiu; Chih-Chun Lee et al.

Frontiers in Immunology, Vol. 14 · 2023 · English · DOAJ Scopus

Autoimmune encephalitis is a rare but critical complication of COVID-19. The management of COVID-19-associated autoimmune encephalitis includes the use of steroids, intravenous immunoglobulin (IVIG), plasmapheresis, and monoclonal antibody therapy. This study presented a patient with critical…

Survival predictor in patients with acute respiratory distress syndrome and diffuse alveolar damage undergoing open lung biopsy

Kuo-Chin Kao; Chih-Hao Chang; Chen-Yiu Hung et al.

PLOS ONE, Vol. 12 No. 7 · 2017 · English · PLOS Scopus

Background: Diffuse alveolar damage (DAD) is a typical pathological finding of open lung biopsies in patients with acute respiratory distress syndrome (ARDS). Patients with ARDS and DAD have been reported to have a poorer prognosis than those without DAD. The aim of this study was to investigate…

Also available at: DOAJ

Immunotherapy and Vaccination in Surgically Resectable Non-Small Cell Lung Cancer (NSCLC)

Li-Chung Chiu; Shu-Min Lin; Yu-Lun Lo et al.

Vaccines, Vol. 9 No. 7 · 2021 · English · DOAJ Scopus

Early-stage NSCLC (stages I and II, and some IIIA diseases) accounts for approximately 30% of non-small cell lung cancer (NSCLC) cases, with surgery being its main treatment modality. The risk of disease recurrence and cancer-related death, however, remains high among NSCLC patients after complete…

Durvalumab as Consolidation Therapy in Post-Concurrent Chemoradiation (CCRT) in Unresectable Stage III Non-Small Cell Lung Cancer Patients: A Multicenter Observational Study

Chin-Chou Wang; Li-Chung Chiu; Jia-Shiuan Ju et al.

Vaccines, Vol. 9 No. 10 · 2021 · English · DOAJ Scopus

Background: The experience of using consolidation durvalumab in post-concurrent chemoradiation (CCRT) unresectable stage III non-small cell lung cancer (NSCLC) is rare in real-world clinical practice, and the factors associated with its efficacy are also unclear. We sought to analyze the efficacy…

Clinical features of anti-SAE1 antibody-positive myositis and interstitial lung disease: a multicenter, retrospective study in Taiwan

Chao-Yang Hsiao; Shu-Chi Tseng; Chung-Yuan Hsu et al.

Frontiers in Immunology, Vol. 15 · 2024 · English · DOAJ Scopus

IntroductionThe clinical characteristics of patients positive for anti-small ubiquitin-like modifier 1-activating enzyme subunit 1 (SAE1) antibodies and diagnosed with idiopathic inflammatory myopathies (IIMs) vary across different cohorts and ethnicities, particularly concerning interstitial lung…

Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway

Chien-Ming Chu; Li-Chung Chiu; Chung-Chieh Yu et al.

Mediators of Inflammation, Vol. 2021 · 2021 · English · DOAJ Scopus

Background. Apoptosis is one of the causes of immune depression in sepsis. Pyroptosis also occurs in sepsis. The toll-like receptor (TLR) 4 and receptor for advanced glycation end products (RAGE) have been shown to play important roles in apoptosis and pyroptosis. However, it is still unknown…

Kynurenine Pathway of Tryptophan Metabolism Is Associated with Hospital Mortality in Patients with Acute Respiratory Distress Syndrome: A Prospective Cohort Study

Li-Chung Chiu; Hsiang-Yu Tang; Chun-Ming Fan et al.

Antioxidants, Vol. 11 No. 10 · 2022 · English · DOAJ Scopus

Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality. Metabolites modulating the inflammatory and immune responses may play a central role in the pathogenesis of ARDS. Most biogenic amines may…

Diagnosis of tuberculosis pleurisy with three endoscopic features pleuroscopy

Chung-Shu Lee; Shih-Hong Li; Chih-Hao Chang et al.

Therapeutic Advances in Respiratory Disease, Vol. 15 · 2021 · English · DOAJ Scopus

Background: Tuberculosis (TB) is a constant threat even with a worldwide active public health campaign. Diagnosis of TB pleurisy is challenging in the case of pleural effusion of unknown origin after aspiration analysis. The study was designed to demonstrate a simple image interpretation technique…

The Clinical Experience of Mycobacterial Culture Yield of Pleural Tissue by Pleuroscopic Pleural Biopsy among Tuberculous Pleurisy Patients

Chung-Shu Lee; Li-Chung Chiu; Chih-Hao Chang et al.

Medicina, Vol. 58 No. 9 · 2022 · English · DOAJ Scopus

Background and Objectives: Tuberculous pleurisy is a common extrapulmonary TB that poses a health threat. However, diagnosis of TB pleurisy is challenging because of the low positivity rate of pleural effusion mycobacterial culture and difficulty in retrieval of optimal pleural tissue. This study…

Comparison of Diagnostic Yield and Safety between Semirigid Pleuroscopic Cryobiopsy and Forceps Biopsy for Undiagnosed Pleural Effusion

Chung-Shu Lee; Shih-Hong Li; Chih-Hao Chang et al.

Canadian Respiratory Journal, Vol. 2019 · 2019 · English · DOAJ Scopus

For undiagnosed pleural effusion, diagnostic yields and safety were similar between pleuroscopic cryobiopsy and forceps biopsy, but cryobiopsy obtained a larger pleural tissue sample than forceps biopsy.

The Co-Expression of Programmed Death-Ligand 1 (PD-L1) in Untreated EGFR-Mutated Metastatic Lung Adenocarcinoma

Ping-Chih Hsu; Chih-Wei Wang; Scott Chih-Hsi Kuo et al.

Biomedicines, Vol. 8 No. 2 · 2020 · English · DOAJ Scopus

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) is the standard first-line therapy for metastatic lung adenocarcinoma harboring sensitive EGFR mutations. Tumor surface programmed death-ligand 1 (PD-L1) is expressed in some metastatic EGFR-mutated lung adenocarcinoma, but its…

The Association between Mechanical Power and Mortality in Patients with Pneumonia Using Pressure-Targeted Ventilation

Huang-Pin Wu; Chien-Ming Chu; Li-Pang Chuang et al.

Diagnostics, Vol. 11 No. 10 · 2021 · English · DOAJ Scopus

Recent studies have reported that mechanical power (MP) is associated with increased mortality in patients with acute respiratory distress syndrome (ARDS). We aimed to investigate the association between 28-day mortality and MP in patients with severe pneumonia. In total, the data of 313 patients…

Maternal and neonatal outcomes of respiratory failure during pregnancy

Chen-Yiu Hung; Han-Chung Hu; Li-Chung Chiu et al.

Journal of the Formosan Medical Association, Vol. 117 No. 5 · 2018 · English · DOAJ Scopus

Background: Obstetric patients comprise a limited portion of intensive care unit patients, but they often present with unfamiliar conditions and exhibit the potential for catastrophic deterioration. This study evaluated the maternal and neonatal outcomes of respiratory failure during pregnancy…

Blood Cadmium Levels and Oxygen Desaturation during the 6-Minute Walk Test in Patients with Chronic Obstructive Pulmonary Disease

Li-Chung Chiu; Ping-Chih Hsu; Tzung-Hai Yen et al.

Medicina, Vol. 57 No. 11 · 2021 · English · DOAJ Scopus

Background and Objectives: chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and a history of exposure to noxious stimuli. Cigarette smoking is the most important causal factor for developing COPD. Cadmium, a minor metallic element, is one of the main…

Factors associated with prolonged progression‐free survival of patients treated with first‐line afatinib for advanced epidermal growth factor receptor‐mutated non‐small cell lung cancer

Li‐Chung Chiu; Ping‐Chih Hsu; Chin‐Chou Wang et al.

Thoracic Cancer, Vol. 15 No. 7 · 2024 · English · DOAJ Scopus

Abstract Background This study aimed to investigate the factors associated with prolonged progression‐free survival (PFS) (>36 months) of advanced non‐small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations treated with first‐line afatinib. Methods We…

Outcomes of severe H1N1 pneumoniae: A retrospective study at intensive care units

Shih-Hong Li; Meng-Jer Hsieh; Shih-Wei Lin et al.

Journal of the Formosan Medical Association, Vol. 119 No. 1 · 2020 · English · DOAJ Scopus

Background: The incidence of acute respiratory distress syndrome (ARDS) and the mortality rate of H1N1 influenza pneumonia are unclear. The aim of this study is to investigate the clinical features and outcomes of adult patients admitted to intensive care units (ICUs) with H1N1 pneumonia related…

Dacomitinib as a First‐Line Therapy for Advanced EGFR‐Mutated Non‐Small Cell Lung Cancer Without Brain Metastases: A Multicenter Retrospective Observational Study

Ping‐Chih Hsu; How‐Wen Ko; Li‐Chung Chiu et al.

Cancer Medicine, Vol. 15 No. 3 · 2026 · English · DOAJ Scopus

ABSTRACT Background Real‐world evidence regarding the use of dacomitinib as a first‐line therapy for advanced non‐small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations remains limited. This multicenter, retrospective cohort study aimed to evaluate the clinical…

Sequential treatment in advanced epidermal growth factor receptor-mutated lung adenocarcinoma patients receiving first-line bevacizumab combined with 1st/2nd-generation EGFR-tyrosine kinase inhibitors

Ping-Chih Hsu; Chun-Yao Huang; Yu-Ching Lin et al.

Frontiers in Oncology, Vol. 13 · 2023 · English · DOAJ Scopus

IntroductionThe clinical outcomes of sequential treatment of advanced epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) patients with first-line bevacizumab combined with 1st/2nd-generation EGFR-TKIs are unclear. Thus, we aimed to analyze the outcomes of these…

Predictors of 30-day mortality in critically ill patients with bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: a five-year retrospective study

Mei-Yuan Teo; Shaw-Woei Leu; Li-Chung Chiu et al.

BMC Infectious Diseases, Vol. 26 No. 1 · 2025 · English · DOAJ Scopus

Abstract Background Infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) are increasingly contributing to mortality in ICU patients. The study aimed to evaluate outcomes, identify mortality predictors, and assess antibiotic strategies for treating KPC-Kp…