28 hasil untuk "Muhammad Adnan Shereen"

COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses

Muhammad Adnan Shereen; Suliman Khan; Abeer Kazmi dkk.

Journal of Advanced Research · 2020 · Inggris · OpenAlex Scopus

The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to…

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Zika virus dysregulates the expression of astrocytic genes involved in neurodevelopment

Muhammad Adnan Shereen; Nadia Bashir; Rui Su dkk.

PLOS Neglected Tropical Diseases, Vol. 15 No. 4 · 2021 · Inggris · PLOS Scopus

Zika virus (ZIKV) is a kind of flavivirus emerged in French Polynesia and Brazil, and has led to a worldwide public health concern since 2016. ZIKV infection causes various neurological conditions, which are associated with fetus brain development or peripheral and central nervous systems (PNS/CNS)…

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Impact of coronavirus outbreak on psychological health

Suliman Khan; Rabeea Siddique; Hongmin Li dkk.

Journal of Global Health · 2020 · Inggris · OpenAlex Scopus

To curb the spread of SARS-CoV-2, large populations are being quarantined across several countries in the world.The practices of isolation and restricting people to their homes can increase the chances of exposure to disturbed daily routines and higher use of electronic devices.

Emergence of a Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2: Biology and Therapeutic Options

Suliman Khan; Rabeea Siddique; Muhammad Adnan Shereen dkk.

Journal of Clinical Microbiology · 2020 · Inggris · OpenAlex Scopus

century (2020) started with the emergence of a novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle…

EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production

Zhen Luo; Rui Su; Wenbiao Wang dkk.

PLOS Pathogens, Vol. 15 No. 11 · 2019 · Inggris · PLOS Scopus

As a neurotropic virus, human Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease (HFMD) and may develop severe neurological disorders in infants. Toll-like receptor 7 (TLR7) acts as an innate immune receptor and is also a death receptor in the central nervous system (CNS). However…

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The spread of novel coronavirus has created an alarming situation worldwide

Suliman Khan; Rabeea Siddique; Ashaq Ali dkk.

Journal of Infection and Public Health, Vol. 13 No. 4 · 2020 · Inggris · DOAJ Scopus

Investigating the Polystyrene (PS) Biodegradation Potential of Phanerochaete chrysosporium Strain NA3: A Newly Isolated Soil Fungus

Muhammad Adnan Shereen; Sadia Mehmood Satti; Asim Abbasi dkk.

Life, Vol. 15 No. 6 · 2025 · Inggris · DOAJ Scopus

Biochemical monomer upcycling of plastic waste and its conversion into value-added products is deemed necessary, as it provides a greener and more sustainable solution to plastic waste management. In the current study, the polystyrene (PS) biodegradation potential of the fungus Phanerochaete…

STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection

Wenbiao Wang; Dingwen Hu; Caifeng Wu dkk.

PLoS Pathogens · 2020 · Inggris · OpenAlex Scopus

One of the fundamental reactions of the innate immune responses to pathogen infection is the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 inflammasome. The stimulator of interferon genes (STING) has the essential roles in innate immune response against pathogen…

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Evidence and speculations: vaccines and therapeutic options for COVID-19 pandemic

Rabeea Siddique; Qian Bai; Muhammad Adnan Shereen dkk.

Human Vaccines & Immunotherapeutics, Vol. 17 No. 4 · 2021 · Inggris · DOAJ Scopus

A novel coronavirus (2019-nCov) emerged in China, at the end of December 2019 which posed an International Public Health Emergency, and later declared as a global pandemic by the World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) named it SARS-CoV-2 (Severe…

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Mingfu Tian; Weiyong Liu; Xiang Li dkk.

Signal Transduction and Targeted Therapy · 2021 · Inggris · OpenAlex Scopus

Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial determinant in COVID-19 prognosis. Understanding the mechanism underlying the SARS-CoV-2-induced cytokine storm is critical for…

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases

Suliman Khan; Rabeea Siddique; Ding Huanfei dkk.

Frontiers in Bioengineering and Biotechnology, Vol. 9 · 2021 · Inggris · DOAJ Scopus

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individual’s quality of life. Although bone has the innate ability to…

DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction

Pan Pan; Geng Li; Miaomiao Shen dkk.

PLOS Pathogens, Vol. 17 No. 7 · 2021 · Inggris · PLOS Scopus

Dengue virus (DENV) is a mosquito-borne pathogen that causes a spectrum of diseases including life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage is a common clinical crisis in DHF/DSS patients and highly associated with increased endothelial…

LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination

Dingwen Hu; Yingchong Wang; Aixin Li dkk.

Virulence, Vol. 12 No. 1 · 2021 · Inggris · DOAJ Scopus

Zika virus (ZIKV) infection can cause severe neurological disorders, including Guillain–Barre syndrome and meningoencephalitis in adults and microcephaly in fetuses. Here, we reveal that laminin receptor 1 (LAMR1) is a novel host resistance factor against ZIKV infection. Mechanistically, we found…

Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar Lavage

Zhen Luo; Chengliang Zhu; Zhihui Ruan dkk.

Frontiers in Medicine, Vol. 8 · 2021 · Inggris · DOAJ Scopus

Objectives: The longitudinal characterization and risk of poor outcomes related to cytokine overproduction in critical coronavirus disease 2019 (COVID-19) patients with hyperinflammation in bronchoalveolar lavage requires further investigation.Methods: We enrolled two critically ill patients with…

The TLR3/IRF1/Type III IFN Axis Facilitates Antiviral Responses against Enterovirus Infections in the Intestine

Rui Su; Muhammad Adnan Shereen; Xiaofeng Zeng dkk.

mBio, Vol. 11 No. 6 · 2020 · Inggris · DOAJ Scopus

ABSTRACT Enteroviruses infect gastrointestinal epithelium cells, cause multiple human diseases, and present public health risks worldwide. However, the mechanisms underlying host immune responses in intestinal mucosa against the early enterovirus infections remain elusive. Here, we showed that…

The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression

Muhammad Sajid; Hafiz Ullah; Kun Yan dkk.

Frontiers in Immunology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

Hepatitis B virus is an enveloped DNA virus, that infects more than three hundred and sixty million people worldwide and leads to severe chronic liver diseases. Interferon-alpha inducible protein 6 (IFI6) is an IFN-stimulated gene (ISG) whose expression is highly regulated by the stimulation of…