10 hasil untuk "Pascal M. Mutie"
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Artikel Jurnal
Lifestyle precision medicine: the next generation in type 2 diabetes prevention?
Abstract The driving force behind the current global type 2 diabetes epidemic is insulin resistance in overweight and obese individuals. Dietary factors, physical inactivity, and sedentary behaviors are the major modifiable risk factors for obesity. Nevertheless, many overweight/obese people do not…
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Artikel Jurnal
Genetic and molecular signatures highlight diverse pathways linking obesity to type 2 diabetes
Abstract Obesity is a major risk factor for type 2 diabetes, a disease affecting approximately 10% of the global population. Obesity is a heterogeneous condition, with different components exerting distinct, and sometimes opposing, effects on type 2 diabetes risk. Here, we aim to identify molecular…
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Artikel Jurnal
Distinct genetic profiles of obesity have different effects on breast cancer risk: leveraging Mendelian randomisation to interrogate causal pathways and identify mediating proteins
Abstract Background Obesity is a well-established risk factor for many cancers, but its association with breast cancer remains inconsistent. Obesity is a highly complex and polygenic condition, driven by multiple biological pathways, some of which have been linked to beneficial health effects…
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Artikel Jurnal
Components of a healthy diet and different types of physical activity and risk of atherothrombotic ischemic stroke: A prospective cohort study
BackgroundDiet and physical activity (PA) are modifiable risk factors thought to influence the risk of ischemic stroke (IS). However, few studies have examined their effect on different subtypes of IS.AimTo examine components of overall diet quality and different types of PA in relation to the risk…
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Artikel Jurnal
Different domains of self-reported physical activity and risk of type 2 diabetes in a population-based Swedish cohort: the Malmö diet and Cancer study
Abstract Background While a dose-response relationship between physical activity and risk of diabetes has been demonstrated, few studies have assessed the relative importance of different measures of physical activity on diabetes risk. The aim was to examine the association between different…
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Artikel Jurnal
Author Correction: An investigation of causal relationships between prediabetes and vascular complications
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20663-6
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Artikel Jurnal
An investigation of causal relationships between prediabetes and vascular complications
Prediabetes has been associated with diabetes complications, but these relationships may be confounded. Here the authors show, using genetic data in causal inference analyses, that prediabetes raises risk of coronary heart disease, but not other diabetes complications.
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Artikel Jurnal
LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and that human LRIG1 variants are associated with…
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Artikel Jurnal Teks lengkap
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to the liver and, ultimately, hepatocellular…
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