46 hasil untuk "Pingping He"
Menampilkan 1–20 · 1,02 detik · RSS
-
Artikel Jurnal
The function of histone methyltransferase SETDB1 and its roles in liver cancer
Epigenetic alterations in gene expression have been implicated in cancer development and tumor immune escape, with posttranslational histone or non-histone modifications representing attractive targets for disease surveillance and therapy. SET domain bifurcated 1 (SETDB1) is a histone lysine…
-
Artikel Jurnal Teks lengkap
Study on the influence of the mass eccentric wheelset on the wheel polygonal wear of high-speed trains
In the paper, the finite element model of the wheelset-track system is established, and the explicit transient dynamic analysis method is used to study the dynamic response. The research results show that when the mass eccentric wheelset rolls on the rails, the eccentric mass will increase the…
Juga tersedia di: DOAJ
-
Artikel Jurnal
The effect of internet use on depressive symptoms in older adults: based on the chain mediating role of physical exercise and self-rated health
BackgroundDepressive symptoms in older adults have been a major public health problem. Although many studies have suggested a potential relationship between Internet use and depressive symptoms, the underlying mechanisms of this relationship among older adults remain unclear. This study aimed to…
-
Artikel Jurnal
Transcription Factor-7-Like-2 (TCF7L2) in Atherosclerosis: A Potential Biomarker and Therapeutic Target
Transcription factor-7-like-2 (TCF7L2), a vital member of the T-cell factor/lymphoid enhancer factor (TCF/LEF) family, plays an important role in normal human physiological and pathological processes. TCF7L2 exhibits multiple anti-atherosclerotic effects through the activation of specific molecular…
-
Artikel Jurnal Teks lengkap
Effects of Gold Tailings Fineness and Dosage on the Rheology and Mechanical Properties of ECC
This study systematically investigates the effects of gold tailings (GT) sand substitution levels and particle fineness on the rheological behavior, mechanical properties, and microstructural characteristics of Engineered Cementitious Composites (ECC). The results demonstrate that incorporating…
-
Artikel Jurnal
Prediction of bone metastasis of prostate cancer based on intratumoral and peritumoral radiomics of MRI T2WI combined with ADC images
ObjectiveTo investigate the value of intratumoral and peritumoral MRI radiomic models in predicting bone metastasis of prostate cancer patients using T2WI combined with ADC images.Materials and methodA total of 144 patients with prostate cancer who underwent preoperative MRI (T2WI and DWI) were…
-
Artikel Jurnal
Breakthroughs of ultrasound-targeted microbubble destruction in treating myocardial ischemia-reperfusion injury: from angiogenesis regulation to precise inflammation suppression
Myocardial ischemia-reperfusion injury (MIRI), a frequent complication in acute myocardial infarction (AMI) treatment, arises from complex mechanisms including oxidative stress, inflammation, and mitochondrial dysfunction, which impair myocardial repair and recovery. Current therapies for MIRI…
-
Artikel Jurnal
FKBP5 Exacerbates Impairments in Cerebral Ischemic Stroke by Inducing Autophagy via the AKT/FOXO3 Pathway
Cerebral ischemic stroke is regarded as one of the most serious diseases in the human central nervous system. The secondary ischemia and reperfusion (I/R) injury increased the difficulty of treatment. Moreover, the latent molecular regulating mechanism in I/R injury is still unclear. Based on our…
-
Artikel Jurnal Teks lengkap
Pharmacogenomics of Tirzepatide: Genomic Insights into Dual GIP/GLP-1 Agonist Response in Type 2 Diabetes and Atherosclerosis
Type 2 diabetes mellitus (T2DM) is frequently complicated by atherosclerosis (AS), with substantial overlap in their underlying pathophysiological mechanisms, posing serious threats to patient health. Tirzepatide, a novel dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and…
-
Artikel Jurnal
Stress and influencing factors of public health and preventive medicine students in the post-pandemic period: a cross-sectional study in Changsha, China
ObjectivesLittle is known about the stress levels and associated factors of public health and preventive medicine students in the post-pandemic period. This study aims to investigate the stress levels of these students in the post-COVID-19 era and to determine the association of personal…
-
Artikel Jurnal
Effects of mold exposure on self-rated health in Chinese older adults: a moderated mediation model of anxiety and indoor ventilation frequency
Abstract Background The impact of indoor environmental quality on the health of older adults is becoming increasingly evident in the context of an aging population. Mold exposure, a common source of residential environmental hazards, may pose a significant threat to self-rated health in older…
-
Artikel Jurnal
Indoor ventilation frequency and cognitive function among Chinese old adults: the multiple mediation effect of anxiety and self-rated health
Abstract Background China is experiencing an increasingly serious aging population. Cognitive function is an important factor and guarantee for the quality of life of older people. Therefore, to achieve healthy aging, this study aimed to examine the sequential multiple mediating effects of indoor…
-
Artikel Jurnal Teks lengkap
Mechanical Properties of EGC Incorporating Ternary Precursors
This study investigates the composition–property relationships in ternary engineered geopolymer composites (EGCs) using a simplex centroid design method to optimize the synergy between ground granulated blast furnace slag (GGBS), fly ash (FA), and metakaolin (MK). Mechanical testing revealed that…
-
Artikel Jurnal
Study on the relationship between indoor ventilation frequency and anxiety and depression symptoms in older persons: based on the data of 2018 CLHLS
Abstract Background To investigate the association between indoor ventilation frequency and symptoms of depression and anxiety in older persons. Methods A binary logistic regression model was used to analyze the effects of indoor ventilation frequency on depression and anxiety by using data from…
-
Artikel Jurnal Teks lengkap
Bimetallic Fe3O4@Co3O4/CN as a Nanozyme with Dual Enzyme-Mimic Activities for the Colorimetric Determination of Mercury(II)
Colorimetric biosensor-based nanozymes have received considerable attention in various fields thanks to the advantages of the simple preparation, good stability, and regulable catalytic activity of nanozymes. In this study, a bimetallic nanozyme Fe3O4@Co3O4/CN was prepared via the high-temperature…
-
Artikel Jurnal
The application of the Attention-Relevance-Confidence-Satisfaction motivation model-based instructional design in advanced nursing practice course: a mixed-methods study
Abstract Background The advanced nursing practice course is a core course for graduate nursing students, aimed at enhancing their comprehensive clinical competence and professionalism. The Attention-Relevance-Confidence-Satisfaction motivation model provides a theoretical framework for…
-
Artikel Jurnal
Suicidal ideation and influencing factors among hospitalized older adults with functional impairments: a mixed-methods study
Abstract Background Compared to their healthy counterparts, hospitalized older adults with functional impairments face a heightened risk of suicidal ideation due to disease-related pain, loss of independence, and reduced social engagement, positioning them as a high-risk demographic for suicide…