14 hasil untuk "Rizal Azis"
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Artikel Jurnal
Conditioned Medium of IGF1-Induced Human Wharton’s Jelly Mesenchymal Stem Cells Effects on Sox9 Gene Expression and Level of COL2 and IL1β in Osteoarthritic Chondrocytes
Wharton’s jelly mesenchymal stem cells (WJMSCs) hold promises for treating osteoarthritis (OA) due to their great capacity for regeneration and their accessibility. However, obstacles like poor cell survival and differentiation prevent them from being used in transplants. Thus, this study examined…
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Artikel Jurnal
Antiaging properties of chlorogenic acid through protein and gene biomarkers in human skin fibroblast cells as photoaging model
Background and purpose: Chlorogenic acid (CA) is a natural chemical that promises antiaging activity against photoaging skin damage. This research examined CA activities in mitigating skin photoaging. Experimental approach: UV-exposed human skin fibroblast cells were subjected to CA at 6.25, 12.5…
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Artikel Jurnal
Anti‐inflammatory properties of conditioned medium from human Wharton’s jelly mesenchymal stem cells
Acute respiratory distress syndrome (ARDS) is a critical respiratory dysfunction triggered by intense in‐ flammation, microvascular damage, and increased epithelial and pulmonary vascular permeability. Human Wharton’s jelly mesenchymal stem cells (hWJMSCs) possess regenerative and anti‐inflammatory…
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Artikel Jurnal
The Potential of Ethanol Extract of Pasak Bumi Roots (Eurycoma longifolia Jack) as an Anti-Prostate Cancer In Vitro Against PC-3 Cells
The prevalence of prostate cancer cases in men is expected to continue increase. In 2040, it is estimated that there will be 2.293.818 new cases and a 1.05% increase in the death rate due to prostate cancer. Eurycoma longifolia Jack roots extract (ELE) has potential as an alternative treatment…
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Artikel Jurnal
The Potential of Pasak Bumi (Eurycoma longifolia Jack) Root Extract Nanoparticles as Anti-Prostate Cancer Agent against Cell Cycle Regulation, Apoptosis, and Senescence based on In Vitro Tests
Prostate cancer poses a major health challenge worldwide, with increasing incidence rates and limited current treatment modalities, which highlights the urgent need for innovative therapeutic alternatives. Utilizing nanoparticles derived from plant extracts is emerging as a promising solution…
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Artikel Jurnal Teks lengkap
Potential of epicatechin as antioxidant and antiaging in UV-induced BJ cells by regulating COL1A1, FGF-2, GPX-1, and MMP-1 gene, protein levels, and apoptosis
Background Oxidative stress caused by exposure to ultraviolet (UV) light on the skin can damage deoxyribonucleic acid (DNA) and cause keratinocytes to undergo apoptosis. Endogenous antioxidants which play a role in trapping free radicals are also unable to overcome excess reactive oxygen species…
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Artikel Jurnal
Immune System and Hepatic Stellate Cells’ Crosstalk in Liver Fibrosis: Pathways and Therapeutic Potential
Liver fibrosis, characterized by the excessive deposition of extracellular matrix (ECM) driven by hepatic stellate cells (HSCs) activation, remains a critical challenge due to its progression to cirrhosis and hepatocellular carcinoma (HCC). This review clarifies the complex crosstalk between the…
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Artikel Jurnal
Potential of Secretome Hydrogel for Wound Healing in LPS- and Scratch-Induced BJ Cells as an Inflammation Model
Wound healing often requires specialized interventions to accelerate recovery due to prolonged inflammation and limited regenerative factors. Umbilical Cord Mesenchymal Stem Cells secretome (UCMSCs) comprises various cytokines and growth factors that can promote wound healing. This study aims to…
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Artikel Jurnal
Mangosteen Peel Extract (Garcinia mangostana L.) as a Potential Complementary of Leukemia Therapy: In Vitro and In Silico Studies
Leukemia is caused by abnormal white blood cell proliferation that leads to disruption of conventional blood cell functions. Mangosteen (Garcinia mangostana L.) contains phytochemical compounds with strong anticancer properties, according to various cancer studies. This study investigated the…
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Artikel Jurnal
Potential of Bitter Melon (Momordica charantia L.) Extract for Chronic Kidney Disease Based on In Vitro Study via TGF/SMADs Signaling, Antioxidant, Antiinflammation, Apoptosis Inducer Activities
Chronic kidney disease (CKD) is a physiological abnormality in the kidneys whose prevalence is expected to continue to increase. On the other hand, Bitter melon (Momordica charantia L.) is known to have the potential to manage CKD. This study explores the compound content of M. charantia ethanol…
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Artikel Jurnal
Protective effects of turmeric extract, curcumin, demethoxycurcumin, bis-demethoxycurcumin, and ar-turmerone from Curcuma longa L. rhizomes on acetaminophen-induced hepatotoxicity in HepG2 cells
Objective: To assess the effects of turmeric extract and its compounds on oxidative stress, inflammation, and apoptosis in acetaminophen-induced liver injury. Methods: HepG2 cells were administered with acetaminophen (40 mM) to induce hepatotoxicity, followed by treatment with turmeric extract and…
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Artikel Jurnal Teks lengkap
Hepatoprotective effect of hUC-MSC secretome in LPS-induced HepG2 cells
Objective(s): This study aimed to evaluate the cytotoxicity and hepatoprotective effects of human umbilical cord mesenchymal stem cell–derived secretome (hUCMSC-Sec) in lipopolysaccharide (LPS)-induced HepG2 cells as an in vitro model of liver inflammation.Materials and Methods: hUCMSC-Sec was…
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Artikel Jurnal
Salacca zalacca extract's antiaging effect on aging genes, protein levels, and apoptosis in UV-induced fibroblast cells
الملخص: أهداف البحث: يُمكن أن يُسرّع التعرض للأشعة فوق البنفسجية شيخوخة الجلد. ولاستخدام المواد الكيميائية المُضادة للشيخوخة آثار جانبية طويلة المدى. ومن المعروف أن المكونات الطبيعية لفاكهة الثعبان (سالاكا زالاكا) تتميز بخصائص حيوية نشطة، مثل البوليفينولات والفلافونويدات وحمض الكلوروجينيك وحمض…