17 hasil untuk "Safwaan Adam"

Mathematical modelling of the most effective goal of cholesterol-lowering treatment in primary prevention

Handrean Soran; Safwaan Adam; Paul Durrington dkk.

BMJ Open, Vol. 12 No. 5 · 2022 · Inggris · DOAJ Scopus

Objective To compare quantitatively different recommended goals for cholesterol-lowering treatment in the primary prevention of atherosclerotic cardiovascular disease (ASCVD).Design Outcomes at pretreatment low-density lipoprotein (LDL) cholesterol concentrations from 2 to 5 mmol/L and 10-year…

Potential pitfalls in diagnosis of immunotherapy-induced hypothalamic–pituitary–adrenal axis abnormalities: a clinical case

Yixi Bi; Safwaan Adam; Viktoria Chatzimavridou dkk.

Endocrine Oncology, Vol. 2 No. 1 · 2023 · Inggris · DOAJ Scopus

Short synacthen tests (SST) are frequently used for assessing adrenocorticotropin hormone (ACTH) deficiency. In this study, we present the case of a 53-year-old man receiving immunotherapy for metastatic melanoma, who subsequently developed immune checkpoint inhibitor (ICI)-induced hypothyroidism…

Bilateral adrenal masses and adrenal insufficiency: a rare case of primary adrenal lymphoma

Aya Eladl; Maria Michaelidou; Adam Gibb dkk.

Endocrinology, Diabetes & Metabolism Case Reports, Vol. 2026 No. 1 · 2026 · Inggris · DOAJ Scopus

Primary adrenal lymphoma (PAL) is a rare malignancy typically considered in patients presenting with features of adrenal insufficiency and bilateral adrenal gland enlargement. Early diagnosis and differentiation from other causes of bilateral adrenal masses are essential to guide appropriate…

Diagnostic criteria and proposed management of immune-related endocrinopathies following immune checkpoint inhibitor therapy for cancer

Ruth Percik; Sherwin Criseno; Safwaan Adam dkk.

Endocrine Connections, Vol. 12 No. 5 · 2023 · Inggris · DOAJ Scopus

Checkpoint inhibitors are now widely used in the management of many cancers. Endocrine toxicity is amongst the most common side effects. These endocrinopathies differ from most other immune-related toxicities in frequently being irreversible and rarely requiring cessation of checkpoint inhibitor…

Acute presentations in neoadjuvant chemotherapy/immune checkpoint inhibition for triple negative breast cancer: experiences and impact from real-world data

Tim Cooksley; Safwaan Adam; Bence Nagy dkk.

Breast, Vol. 83 · 2025 · Inggris · DOAJ Scopus

Background: Recent data showed benefit of the addition of immune checkpoint inhibitor (ICI) therapy to cytotoxic chemotherapy in the neoadjuvant setting for patients with early triple negative breast cancer. Acute presentations in patients treated with ICI therapy and combined chemotherapy/ICI…

Corneal confocal microscopy is a rapid reproducible ophthalmic technique for quantifying corneal nerve abnormalities

Alise Kalteniece; Maryam Ferdousi; Safwaan Adam dkk.

PLOS ONE, Vol. 12 No. 8 · 2017 · Inggris · PLOS Scopus

Purpose: To assess the effect of applying a protocol for image selection and the number of images required for adequate quantification of corneal nerve pathology using in vivo corneal confocal microscopy (IVCCM). Methods: IVCCM was performed in 35 participants by a single examiner. For each…

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The Relationship Between Obesity and Cancer: Epidemiology, Pathophysiology, and the Effect of Obesity Treatment on Cancer

Yasmin Ingram; Oluwasegun Olujide; Nabiha Sheikh dkk.

Current Oncology, Vol. 32 No. 6 · 2025 · Inggris · DOAJ Scopus

There is growing evidence relating to the risk of cancer in people with obesity. Obesity is already established as one of the strongest predisposing factors to cancer, and ‘obesity-related’ cancers have been defined in previous studies. In this review article, we examine the epidemiological…

Obesity: A critical risk factor in the COVID ‐19 pandemic

See Kwok; Safwaan Adam; Jan Hoong Ho dkk.

Clinical Obesity · 2020 · Inggris · OpenAlex Scopus

Summary Obesity is an emerging independent risk factor for susceptibility to and severity of coronavirus disease 2019 (COVID‐19) caused by the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Previous viral pandemics have shown that obesity, particularly severe obesity (BMI > 40…

Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation

Helene A. Fachim; Kirk Siddals; Nagaraj Malipatil dkk.

Adipocyte, Vol. 9 No. 1 · 2020 · Inggris · DOAJ Scopus

Aims: We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impaired glucose regulation (IGR), the results were compared to bariatric surgery, considering it an intensive change. Methods: Twenty participants with…

Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy

Jan Hoong Ho; Safwaan Adam; Shazli Azmi dkk.

PLOS ONE, Vol. 14 No. 9 · 2019 · Inggris · PLOS Scopus

Context: Multiple factors contribute to sexual dysfunction in men with obesity. Sex hormone levels are commonly abnormal in men with obesity and this abnormality is often the focus of management in clinical practice. The role of small fibre neuropathy in obesity-related sexual dysfunction is not…

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Greater corneal nerve loss at the inferior whorl in obesity

Zohaib Iqbal; Maryam Ferdousi; Alise Kalteniece dkk.

Heliyon, Vol. 11 No. 5 · 2025 · Inggris · DOAJ Scopus

Background: Diabetic neuropathy is a dying-back neuropathy with evidence of greater distal corneal nerve loss at the inferior whorl. Individuals with obesity exhibit neuropathy and central corneal nerve loss. We have assessed whether there was evidence of greater corneal nerve loss at the inferior…

Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy

Shaishav Dhage; Maryam Ferdousi; Safwaan Adam dkk.

Scientific Reports, Vol. 11 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract Accurately quantifying the progression of diabetic peripheral neuropathy is key to identify individuals who will progress to foot ulceration and to power clinical intervention trials. We have undertaken detailed neuropathy phenotyping to assess the longitudinal utility of different…

High density lipoprotein-associated miRNA is increased following Roux-en-Y gastric bypass surgery for severe obesity

Jan Hoong Ho; Kwok Leung Ong; Luisa F. Cuesta Torres dkk.

Journal of Lipid Research, Vol. 62 · 2021 · Inggris · DOAJ Scopus

Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed weight-loss procedures, but how severe obesity and RYGB affect circulating HDL-associated microRNAs (miRNAs) remains unclear. Here, we aim to investigate how HDL-associated miRNAs are regulated in severe obesity and how weight…

The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity

Shazli Azmi; Maryam Ferdousi; Yifen Liu dkk.

Scientific Reports, Vol. 11 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract Obesity and associated dyslipidemia may contribute to increased cardiovascular disease. Obesity has also been associated with neuropathy. We have investigated presence of peripheral nerve damage in patients with severe obesity without type 2 diabetes and the status of metabolic syndrome…

Effect of Roux-en-Y Bariatric Surgery on Lipoproteins, Insulin Resistance, and Systemic and Vascular Inflammation in Obesity and Diabetes

Rahul Yadav; Salam Hama; Yifen Liu dkk.

Frontiers in Immunology, Vol. 8 · 2017 · Inggris · DOAJ Scopus

PurposeObesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM).ObjectiveTo evaluate changes in lipoproteins, insulin resistance…