18 hasil untuk "Sebastian Yu"
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Artikel Jurnal Teks lengkap
Molecular Mechanisms of Cutaneous Immune-Related Adverse Events (irAEs) Induced by Immune Checkpoint Inhibitors
Over the past few decades, immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic options for the treatment of various cancers. These novel treatments effectively target key mediators of immune checkpoint pathways. Currently, ICIs primarily consist of monoclonal antibodies that…
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A patient with subacute cutaneous lupus erythematosus along Blaschko lines: Implications for the role of keratinocytes in lupus erythematosus
Blaschko lines are manifestations of cutaneous mosaicism, with apparent contrast between normal cells and abnormal cells, which carry postzygotic mutations. Linear cutaneous lupus erythematosus is a rare subset of cutaneous lupus erythematosus (CLE), characterized by skin lesions along Blaschko…
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Artikel Jurnal Teks lengkap
Hidradenitis Suppurativa: An Understanding of Genetic Factors and Treatment
Hidradenitis suppurativa (HS), recognized as a chronic and debilitating skin disease, presents significant challenges in both diagnosis and treatment. This review explores the clinical manifestations, genetic landscape, and molecular mechanisms underlying HS. The disease’s association with a…
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Artikel Jurnal Teks lengkap
Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a psychiatric disorder that causes debilitating functional impairment in patients. Observations from survivors of traumatic historical events solidify that this disease is not only associated with personal experiences but can also be inherited from familial…
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Artikel Jurnal Teks lengkap
Cutaneous Adverse Events Associated with Immune Checkpoint Inhibitors: A Review Article
Immune checkpoint inhibitors (ICIs) have emerged as novel options that are effective in treating various cancers. They are monoclonal antibodies that target cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1), and programmed cell death-ligand 1 (PD-L1). However, activation of…
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Prevalence of schizophrenia in patients with psoriasis: a nationwide study
Background/Objective: The prevalence of selected psychiatric disorders, such as depression and anxiety, is higher in patients with psoriasis. However, the association between psoriasis and schizophrenia is less clear. Here, we investigated whether the prevalence of schizophrenia is higher in…
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Drug survival of biologic agents in patients with psoriatic arthritis from a medical center in southern Taiwan
Background: Psoriasis is a chronic inflammatory disease involving the skin and/or joints. Till 2016, there were five biologic agents for psoriatic arthritis treatment in Taiwan: etanercept, adalimumab, golimumab, ustekinumab, and secukinumab. Although European guidelines recommend tumor necrosis…
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Is psoriasis an independent risk factor of renal disease? A nationwide retrospective cohort study from 1996 to 2010
Background: Psoriasis is a chronic inflammatory disease that affects the skin, joints, and cardiovascular system. Although a potential association of end-stage renal disease (ESRD) with psoriasis has been demonstrated in patients, the potential for the use of cyclosporin in these patients for the…
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Prenatal infection predisposes offspring to enhanced susceptibility to imiquimod-mediated psoriasiform dermatitis in mice
Background: Infection can upregulate T helper 17 (Th17) signaling and exacerbate psoriasis. Literature has indicated that prenatal infection induces embryonic development toward Th17 signaling and is a risk factor for developing certain Th17-skewing disorders such as autism in offspring. However…
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Adherence to an anti-inflammatory diet is associated with lower Alzheimer’s disease mortality: A modifiable risk factor in a national cohort
Background: Chronic neuroinflammation contributes to Alzheimer’s disease (AD) pathogenesis, and diet is a modifiable factor influencing inflammation. The impact of an anti-inflammatory diet on AD-specific mortality remains unclear. Objectives: To examine the association between adherence to an…
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Artikel Jurnal
Arsenic leads to autophagy of keratinocytes by increasing aquaporin 3 expression
Abstract Exposure to arsenic, a ubiquitous metalloid on Earth, results in human cancers. Skin cancer is the most common arsenical cancers. Both autophagy and aquaporin pathway are known to promote carcinogenesis. However, the mechanisms by which arsenic regulates aquaporin and autophagy in…
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Immune perturbation in arsenic-induced adverse health effects and cancers
Chronic exposure to inorganic arsenic remains a global health concern and is strongly associated with cutaneous malignancies, pigmentation abnormalities, internal cancers, and a range of non-malignant outcomes. In addition to direct genotoxic stress and epigenetic remodeling, arsenic exerts broad…
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The effect of papain hydrolysis on tropomyosin levels in shrimp
Shrimp allergy is a serious public health problem. Epidemiological studies indicated the main cause of food allergy is the ingestion of shrimp and crab. Consequently, reducing the risk of shrimp and crab allergy is a major research focus. Few studies have demonstrated the effect of enzyme…
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Artikel Jurnal
Chronic blue light exposure induced spatial anxiety in an adolescent mouse model: Per2 upregulation and altered brain resting-state functional activity
Background: Blue light (BL) is the primary component of light emitted from 3C devices. The use of 3C (computers, consumer electronics, and communication) devices has been increasing among all age groups. How social interaction and spatial cognition are affected in adolescents after long-term 3C…
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Chronic blue light-emitting diode exposure harvests gut dysbiosis related to cholesterol dysregulation
Night shift workers have been associated with circadian dysregulation and metabolic disorders, which are tightly coevolved with gut microbiota. The chronic impacts of light-emitting diode (LED) lighting at night on gut microbiota and serum lipids were investigated. Male C57BL/6 mice were exposed to…
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Artikel Jurnal
Taiwanese Dermatological Association consensus recommendations for the diagnosis, treatment, and management of generalized pustular psoriasis
Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening skin disease characterized by relapsing and remitting flares of sterile neutrophilic pustules and systemic inflammation. The definition of GPP is inconsistent globally, with large discrepancies in clinical management. To…