18 hasil untuk "Simon Harding"
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Artikel Jurnal
Development and validation of a novel prognostic model for predicting AMD progression using longitudinal fundus images
Objective To develop a prognostic tool to predict the progression of age-related eye disease progression using longitudinal colour fundus imaging.Methods and analysis Previous prognostic models using deep learning with imaging data require annotation during training or only use a single time point…
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Artikel Jurnal
Cross-tier Web Programming for Curated Databases: a Case Study
Curated databases have become important sources of information across several scientific disciplines, and as the result of manual work of experts, often become important reference works. Features such as provenance tracking, archiving, and data citation are widely regarded as important features for…
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Artikel Jurnal
Cross-tier Web Programming for Curated Databases: a Case Study
Curated databases have become important sources of information across several scientific disciplines, and as the result of manual work of experts, often become important reference works. Features such as provenance tracking, archiving, and data citation are widely regarded as important features for…
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Artikel Jurnal
Learning Spatial Object Localization from Vision on a Humanoid Robot
We present a combined machine learning and computer vision approach for robots to localize objects. It allows our iCub humanoid to quickly learn to provide accurate 3D position estimates (in the centimetre range) of objects seen. Biologically inspired approaches, such as Artificial Neural Networks…
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Artikel Jurnal
Visual risk factors for falls in older adults: a case-control study
Abstract Background Falls are the second leading cause of accidental deaths worldwide mainly in older people. Older people have poor vision and published evidence suggests that it is a risk factor for falls. Less than half of falls clinics assess vision as part of the multi-factorial assessment of…
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Artikel Jurnal
Spatial and spatio-temporal statistical analyses of retinal images: a review of methods and applications
Background Clinical research and management of retinal diseases greatly depend on the interpretation of retinal images and often longitudinally collected images. Retinal images provide context for spatial data, namely the location of specific pathologies within the retina. Longitudinally collected…
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Artikel Jurnal
An effective variational model for simultaneous reconstruction and segmentation of blurred images
The segmentation of blurred images is of great importance. There have been several recent pieces of work to tackle this problem and to link the areas of image segmentation and image deconvolution in the case where the blur function κ is known or of known type, such as Gaussian, but not in the case…
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Artikel Jurnal Teks lengkap
Active management is required to turn the tide for depleted Ostrea edulis stocks from the effects of overfishing, disease and invasive species
The decline of the European oyster Ostrea edulis across its biogeographic range has been driven largely by over-fishing and anthropogenic habitat destruction, often to the point of functional extinction. However, other negatively interacting factors attributing to this catastrophic decline include…
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Artikel Jurnal
Brillouin microspectroscopy data of tissue-mimicking gelatin hydrogels
Brillouin spectroscopy, based on the inelastic scattering of light from thermally driven acoustic waves or phonons [1], holds great promise in the field of life sciences as it provides functionally relevant micromechanical information in a contactless all-optical manner [2]. Due to the complexity…
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Artikel Jurnal
Metformin and incidence of age-related macular degeneration in people with diabetes: a population-based 5-year case-control study
Objective Metformin has been identified as a potential treatment for age-related macular degeneration (AMD). Photographic screening for diabetic retinopathy provides an opportunity to conduct a case-control study with systematic AMD grading. We aimed to investigate associations between metformin…
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Artikel Jurnal
Cerebral malaria: insight into pathology from optical coherence tomography
Abstract We aimed to investigate structural retinal changes in malarial retinopathy (MR) using hand-held optical coherence tomography (HH-OCT) to assess its diagnostic potential. Children with MR (n = 43) underwent ophthalmoscopy, fluorescein angiography and HH-OCT during admission, 1-month (n =…
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Artikel Jurnal
Fenofibrate and progression of retinopathy in adults with diabetes: the randomised placebo-controlled LENS trial
Background Diabetic retinopathy is a leading cause of visual loss. Hypothesis-generating data from cardiovascular outcome trials suggest that fenofibrate therapy may reduce the progression of diabetic retinopathy. Objective To determine whether treatment with fenofibrate reduces the progression of…
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Artikel Jurnal
Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children [version 1; peer review: 2 approved]
Cerebral malaria (CM) remains a significant global health challenge with high morbidity and mortality. Malarial retinopathy has been shown to be diagnostically and prognostically significant in the assessment of CM. The major mechanism of death in paediatric CM is brain swelling. Long term…
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Artikel Jurnal Teks lengkap
The Fourth Global Coral Bleaching Event: Where do we go from here?
The Fourth Global Coral Bleaching Event was officially confirmed by the National Oceanic and Atmospheric Administration (NOAA) and International Coral Reef Initiative (ICRI) on April 15, 2024, with press releases and a coordinated call to arms to address the impacts of climate change…
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Artikel Jurnal
Individualised variable-interval risk-based screening in diabetic retinopathy: the ISDR research programme including RCT
Background Systematic annual screening for sight-threatening diabetic retinopathy is established in several countries but is resource intensive. Personalised (individualised) medicine offers the opportunity to extend screening intervals for people at low risk of progression and to target high-risk…
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Artikel Jurnal
Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia
Purpose The retina provides biomarkers of neuronal and vascular health that offer promising insights into cognitive ageing, mild cognitive impairment and dementia. This article described the rationale and methodology of eye and vision assessments with the aim of supporting the study of dementia in…
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Artikel Jurnal
Socioeconomic risk factors and age-related macular degeneration in the UK Biobank study
Objective There is contrasting evidence on the relationship between socioeconomic status (SES) and age-related macular degeneration (AMD), the most common cause of visual impairment (VI) in developed countries. This study examines the relationship between SES, cardiovascular risk factors and…
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Artikel Jurnal
Gene-Environment Interaction Loci Associated with Refractive Error: SCAMPI Analysis
Purpose: To compare the performance of a novel method for identifying candidate gene-environment interaction loci, Scalable Cauchy Aggregate test using Multiple Phenotypes to test Interactions (SCAMPI) (doi:10.1101/2024.09.10.612314v1), to widely used existing methods, Levene’s test and conditional…