26 results for "Li-Rong Wang"
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Exploiting the similarity of dissimilarities for biomedical applications and enhanced machine learning
The “similarity of dissimilarities” is an emerging paradigm in biomedical science with significant implications for protein function prediction, machine learning (ML), and personalized medicine. In protein function prediction, recognizing dissimilarities alongside similarities provides a more…
Also available at: DOAJ
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Protocol to identify functional doppelgängers and verify biomedical gene expression data using doppelgangerIdentifier
…details on the use and execution of this protocol, please refer to Wang et al. (2022). : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
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Doppelgänger spotting in biomedical gene expression data
Summary: Doppelgänger effects (DEs) occur when samples exhibit chance similarities such that, when split across training and validation sets, inflates the trained machine learning (ML) model performance. This inflationary effect causes misleading confidence on the deployability of the model. Thus…
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Using leaf shape to determine leaf size could be a game-changer. A commentary on: ‘Leaf size estimation based on leaf length, width and shape’
This article comments on: Julian Schrader, Peijian Shi, Dana L Royer, Daniel J Peppe, Rachael V Gallagher, Yirong Li, Rong Wang, Ian J Wright, Leaf size estimation based on leaf length, width and shape, Annals of Botany, Volume 128, Issue 4, 17 September 2021, Pages 395–406…
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Identification of the regulatory networks and hub genes controlling alfalfa floral pigmentation variation using RNA-sequencing analysis
Abstract Background To understand the gene expression networks controlling flower color formation in alfalfa, flowers anthocyanins were identified using two materials with contrasting flower colors, namely Defu and Zhongtian No. 3, and transcriptome analyses of PacBio full-length sequencing…
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Aligning deep learning and interpretable models for blood cell classification: A dual-model framework for explainability
Blood smear examination involves classifying cells by morphology under a microscope, a labour-intensive process prone to subjective variation. Recent deep learning models achieve strong performance in blood cell classification but remain as “black boxes”, offering little clinical transparency. We…
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Accumulated chilling hours during endodormancy impact blooming and fruit shape development in peach (Prunus persica L.)
Winter chill is essential for the growth and development of deciduous species. To understand the relationship between accumulated chilling hours during endodormancy and blooming and fruit shape development, we controlled chilling hours and investigated their effects on blooming date and fruit shape…
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The first case of Francisella novicida infection in Taiwan: bacteraemic pneumonia in a haemodialysis adult
Tularaemia is a zoonotic disease caused by Francisella tularensis (F. tularensis). Human infection is rare and can be life-threatening. F. tularensis subsp. novicida used to be a subspecies of F. tularensis, is now considered a different species, F. novicida. Though less virulent, F. novicida can…
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Moderate Dose of Trolox Preventing the Deleterious Effects of Wi-Fi Radiation on Spermatozoa In vitro through Reduction of Oxidative Stress Damage
Background: The worsening of semen quality, due to the application of Wi-Fi, can be ameliorated by Vitamin E. This study aimed to demonstrate whether a moderate dose of trolox, a new Vitamin E, inhibits oxidative damage on sperms in vitro after exposure to Wi-Fi radiation. Methods: Each of the…
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Melioidosis Outbreak after Typhoon, Southern Taiwan
From July through September 2005, shortly after a typhoon, 40 cases of Burkholderia pseudomallei infection (melioidosis) were identified in southern Taiwan. Two genotypes that had been present in 2000 were identified by pulsed-field gel electrophoresis. Such a case cluster confirms that melioidosis…
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The predictive role of systemic immune-inflammation index on futile recanalization in acute ischemic stroke with mechanical thrombectomy
Background and purpose: Futile recanalization (FR) occurs in patients who achieve successful vessel recanalization but still have a poor prognosis. The aim of this study was to explore the association between systemic immune-inflammation index (SII) and futile recanalization following mechanical…
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Predictors of futile recanalization after endovascular treatment of acute ischemic stroke
Abstract Objective Endovascular therapy (EVT) is the most successful treatment for patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) in the anterior circulation. However, futile recanalization (FR) seriously affects the prognosis of these patients. The aim of this study…
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Association of free fatty acid receptor 2 expression in peripheral blood monocytes with carotid atherosclerosis
Abstract Purpose To investigate the relationship between free fatty acid receptor 2 (FFAR2) expression in peripheral blood monocytes and carotid atherosclerosis (CAS). Methods Between November 2023 and June 2024, individuals who underwent carotid ultrasound in the inpatient or outpatient settings…
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Legionnaires' disease at a medical center in southern Taiwan
Background/purpose: Legionella pneumophila had been recognized as a pathogen for both healthcare-associated and community-acquired pneumonia. We aimed to evaluate clinical features and outcomes of patients with Legionnaires' disease at a tertiary medical center in southern Taiwan. Methods: From…
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Mechanism of human chorionic gonadotropin in endometrial receptivity via the miR‐126‐3p/PI3K/Akt/eNOS axis
Abstract Human chorionic gonadotropin (hCG) might affect endometrial receptivity, exerting integral roles in embryo implantation. This study explored the action of hCG in endometrial receptivity via the miR‐126‐3p/PIK3R2/PI3K/Akt/eNOS axis. The embryo implantation dysfunction (EID) mouse models…
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Development and evaluation of an elisa system for detection of pedv-specific iga antibodies in colostrum
Porcine epidemic diarrhea virus (PEDV) is a devastating swine infectious disease. Development of high-performance methods to diagnose and evaluate viral immune status remains very important to control PEDV. Here, a recombinant S1 protein-based indirect enzyme-linked immunosorbent assay…
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Predictive role of pre-thrombolytic hs-CRP on the safety and efficacy of intravenous thrombolysis in acute ischemic stroke
Abstract Purpose To investigate the predictive role of pre-thrombolytic high sensitivity C-reactive protein (hs-CRP) on the safety and efficacy of intravenous thrombolysis in patients with acute ischemic stroke (AIS). Methods Patients with AIS who underwent intravenous thrombolysis with recombinant…
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Evaluating Chain-of-Thought reasoning in large language models for thyroid ultrasound interpretation: a dual-information approach
ObjectiveTo assess whether reasoning-capable large language models (LLMs) can accurately interpret both qualitative and quantitatively encoded ultrasound features of thyroid nodules within the ACR-TIRADS framework and improve diagnostic reliability.MethodsThis retrospective study analyzed thyroid…