35 hasil untuk "Alexis Mathian"

Acute Posterior Multifocal Placoid Pigment Epitheliopathy as the Initial Manifestation of Sarcoidosis

Adil Darugar; Alexis Mathian; Phuc LeHoang dkk.

Journal of Ophthalmic & Vision Research, Vol. 6 No. 4 · 2011 · Inggris · DOAJ Scopus

Purpose: To report an undiagnosed case of systemic sarcoidosis manifesting with bilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Case Report: A 26-year-old Caucasian man was referred for management of unilateral visual loss together with a paracentral scotoma developing…

Acute Tubular Injury and Renal Arterial Myocyte Vacuolization Following Crizotinib Administration

Hassan Izzedine; Isabelle Brocheriou; Zahir Amoura dkk.

Kidney International Reports, Vol. 6 No. 2 · 2021 · Inggris · DOAJ Scopus

Clinical Note: The evolution of interstitial cystic lung disease associated with anti-RNP antibodies – A decade-long observational case

Raphael Lhote; Samia Boussouar; Alexis Mathian dkk.

Pulmonology, Vol. 31 No. 1 · 2025 · Inggris · DOAJ Scopus

Renal involvement in solid cancers: epidemiological, clinical and histological characteristics study of 154 onconephrology patients

Victor Gueutin; Aurore Cardineau; Alexis Mathian dkk.

BMC Nephrology, Vol. 25 No. 1 · 2024 · Inggris · DOAJ Scopus

Abstract Background Onconephrology is a growing discipline that aims to improve the management of patients with cancer and kidney disease. If kidney histology is an essential key, the anatomopathological data remain weak although essential to this complex management. Methods Patients with active…

Regulatory T Cell Responses to High-Dose Methylprednisolone in Active Systemic Lupus Erythematosus

Alexis Mathian; Romain Jouenne; Driss Chader dkk.

PLOS ONE, Vol. 10 No. 12 · 2015 · Inggris · PLOS Scopus

Background/Purpose: A slight increase in the proportion of circulating regulatory T (Treg) cells has been reported in systemic lupus erythematosus (SLE) patients taking oral prednisone. The effects of intravenous (IV) high dose methylprednisolone (MP) on Tregs have not yet been described…

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Exhausted Cytotoxic Control of Epstein-Barr Virus in Human Lupus

Martin Larsen; Delphine Sauce; Claire Deback dkk.

PLoS Pathogens, Vol. 7 No. 10 · 2011 · Inggris · PLOS Scopus

Systemic Lupus Erythematosus (SLE) pathology has long been associated with an increased Epstein-Barr Virus (EBV) seropositivity, viremia and cross-reactive serum antibodies specific for both virus and self. It has therefore been postulated that EBV triggers SLE immunopathology, although the…

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Cerebral Vein Thrombosis in the Antiphospholipid Syndrome: Analysis of a Series of 27 Patients and Review of the Literature

Alba Jerez-Lienas; Alexis Mathian; Jenifer Aboab dkk.

Brain Sciences, Vol. 11 No. 12 · 2021 · Inggris · DOAJ Scopus

(1) Background: The Antiphospholipid Syndrome (APS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis, pregnancy morbidity and raised titers of antiphospholipid antibodies. Cerebral vein thrombosis (CVT) is a rare form of cerebrovascular accident and an uncommon…

Association between cumulative glucocorticoid exposure and epicardial adipose tissue volume in systemic lupus erythematosus

Lévi-Dan Azoulay; Nadjia Kachenoura; Samia Boussouar dkk.

EULAR Rheumatology Open, Vol. 2 No. 1 · 2026 · Inggris · DOAJ

Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients

Manon Chauvin; Martin Larsen; Bibiana Quirant dkk.

Frontiers in Cellular and Infection Microbiology, Vol. 11 · 2021 · Inggris · DOAJ Scopus

HighlightsInnate immune activation during Covid-19 infection is associated with pernicious clinical outcome.BackgroundCoronavirus disease 2019 (Covid-19) is a worldwide threat that has already caused more than 3 000 000 deaths. It is characterized by different patterns of disease evolution…

Hyposplenism in systemic lupus erythematosus: biological and radiological characteristics and its association with increased risk of infection

Zahir Amoura; Alexis Mathian; Miguel Hie dkk.

RMD Open, Vol. 12 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective This study aimed to evaluate the prevalence of hyposplenism in patients with systemic lupus erythematosus (SLE) and its association with an increased risk of infection.Methods This single-centre study included patients with SLE who underwent a systematic evaluation for Howell-Jolly bodies…

Comparison of flares in 85 patients with SLE who maintained, discontinued or reduced dose of hydroxychloroquine during a prospective study of ophthalmological screening for retinopathy (PERFOCTAPS Study)

Nathalie Costedoat-Chalumeau; Alexis Mathian; Luc Mouthon dkk.

Lupus Science and Medicine, Vol. 12 No. 1 · 2025 · Inggris · DOAJ Scopus

Objective Little is known about the risk of SLE flares associated with hydroxychloroquine (HCQ) reduction or cessation, especially after ophthalmological screening. We analysed the risk of SLE flares after HCQ reduction or discontinuation after detection of early ophthalmological toxicity.Methods…

Severe thrombocytopenia in antiphospholipid syndrome: a retrospective study of 432 patients

Zahir Amoura; Alexis Mathian; Miguel Hie dkk.

RMD Open, Vol. 12 No. 2 · 2026 · Inggris · DOAJ Scopus

Introduction Antiphospholipid syndrome (APS) is an autoimmune disease characterised by obstetric morbidity and recurrent venous and/or arterial thrombosis. It is frequently associated with systemic lupus erythematosus, and thrombocytopenia is a common manifestation. This study aimed to compare…

Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus

Danielle Perez-Bercoff; Hélène Laude; Morgane Lemaire dkk.

Scientific Reports, Vol. 11 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract APOBEC3 (A3) enzymes are best known for their role as antiviral restriction factors and as mutagens in cancer. Although four of them, A3A, A3B, A3F and A3G, are induced by type-1-interferon (IFN-I), their role in inflammatory conditions is unknown. We thus investigated the expression of…

Outcomes of severe systemic rheumatic disease patients requiring extracorporeal membrane oxygenation

Pierre Bay; Guillaume Lebreton; Alexis Mathian dkk.

Annals of Intensive Care, Vol. 11 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract Background Systemic rheumatic diseases (SRDs) are a group of inflammatory disorders that can require intensive care unit (ICU) admission because of multiorgan involvement with end-organ failure(s). Critically ill SRD patients requiring extracorporeal membrane oxygenation (ECMO) were…

IgA dominates the early neutralizing antibody response to SARS-CoV-2

Delphine Sterlin; Alexis Mathian; Makoto Miyara dkk.

Science Translational Medicine · 2020 · Inggris · OpenAlex Scopus

Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and composed of IgG, IgA, and IgE. Here, we measured acute humoral responses to SARS-CoV-2, including the frequency of antibody-secreting…

Serum lipidomic and metabolomic signatures link epicardial adipose tissue to cardiovascular diseases in SLE: a post-hoc analysis

Farid Ichou; Alexis Mathian; Miguel Hie dkk.

Lupus Science and Medicine, Vol. 13 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective Cardiovascular diseases are a leading cause of morbidity and mortality in SLE. In this target population, epicardial adipose tissue (EAT) volume is increased, but its determinants and roles are poorly understood. This study aimed to assess the circulating metabolomic and lipidomic…

Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosusResearch in context

Fanny Urbain; Maharajah Ponnaiah; Farid Ichou dkk.

EBioMedicine, Vol. 96 · 2023 · Inggris · DOAJ Scopus

Summary: Background: Patients with systemic lupus erythematosus (SLE) exhibit a high risk for cardiovascular diseases (CVD) which is not fully explained by the classical Framingham risk factors. SLE is characterized by major metabolic alterations which can contribute to the elevated prevalence of…

Vasculitis and familial Mediterranean fever: Description of 22 French adults from the juvenile inflammatory rheumatism cohort

Salam Abbara; Jean-Benoit Monfort; Léa Savey dkk.

Frontiers in Medicine, Vol. 9 · 2022 · Inggris · DOAJ Scopus

ObjectiveThe frequency of vasculitis may be increased in patients with Familial Mediterranean Fever (FMF), according to several studies. Our aim was to assess the characteristics of French adult patients with both diseases.MethodsPatients with vasculitis were selected from patients followed for FMF…