17 hasil untuk "Andrei Prodan"
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Artikel Jurnal
Does disease start in the mouth, the gut or both?
Oral bacteria colonize the gut more frequently than previously thought.
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Artikel Jurnal Teks lengkap
Comparing bioinformatic pipelines for microbial 16S rRNA amplicon sequencing
Microbial amplicon sequencing studies are an important tool in biological and biomedical research. Widespread 16S rRNA gene microbial surveys have shed light on the structure of many ecosystems inhabited by bacteria, including the human body. However, specialized software and algorithms are needed…
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Artikel Jurnal Teks lengkap
Gut Microbiota in Hypertension and Atherosclerosis: A Review
Gut microbiota and its metabolites such as short chain fatty acids (SCFA), lipopolysaccharides (LPS), and trimethylamine-N-oxide (TMAO) impact cardiovascular health. In this review, we discuss how gut microbiota and gut metabolites can affect hypertension and atherosclerosis. Hypertensive patients…
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Artikel Jurnal Teks lengkap
A Study of the Variation in the Salivary Peptide Profiles of Young Healthy Adults Acquired Using MALDI-TOF MS
A cross-sectional observational study was conducted to evaluate the inter-individual variation in the MALDI-TOF MS peptide profiles of unstimulated whole saliva in a population of 268 systemically healthy adults aged 18–30 yr (150 males and 118 females) with no apparent caries lesions or…
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Artikel Jurnal
Untargeted accurate identification of highly pathogenic bacteria directly from blood culture flasks
To improve the preparedness against exposure to highly pathogenic bacteria and to anticipate the wide variety of bacteria that can cause bloodstream infections (BSIs), a safe, unbiased and highly accurate identification method was developed. Our liquid chromatography-tandem mass spectrometry…
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Artikel Jurnal
Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites
Background: Enteroendocrine cells are essential for the regulation of glucose metabolism, but it is unknown whether they are associated with clinical features of metabolic syndrome (MetS) and fasting plasma metabolites. Objective: We aimed to identify fasting plasma metabolites that associate with…
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Artikel Jurnal
Intestinal acetate and butyrate availability is associated with glucose metabolism in healthy individuals
Summary: Animal studies suggest that short-chain fatty acids acetate and butyrate are key players in the gut-brain axis and may affect insulin sensitivity. We investigated the association of intestinal acetate and butyrate availability (measured by butyryl-coenzyme A transferase (ButCoA) gene…
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Artikel Jurnal
Biopurification using non-growing microorganisms to improve plant protein ingredients
Abstract Securing a sustainable global food supply for a growing population requires a shift toward a more plant-based diet. The application of plant-based proteins is therefore increasing, but unpleasant off-flavors complicate their use. Here, we screened 97 microorganisms for their potential to…
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Artikel Jurnal
Early development of infant gut microbiota in relation to breastfeeding and human milk oligosaccharides
BackgroundInfant gut microbiota composition is influenced by various factors early in life. Here, we investigate associations between infant gut microbiome development, infant age, breastfeeding duration, and human milk oligosaccharides (HMO) composition in breastmilk.MethodsA total of 94…
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Artikel Jurnal
10 × Genomics Flex Gene Expression is a powerful tool for single-cell transcriptomics of xenografts models
Abstract The 10 × Genomics Flex Gene Expression protocol is a probe-based method that profiles fixed or frozen material, simplifying sample handling before scRNA-seq. Although probes exist only for human and mouse, we show that xenograft samples containing mixed human–mouse cells can be profiled by…
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Artikel Jurnal Teks lengkap
Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial
Objective Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell destruction. A gut microbiota–immunological interplay is involved in the pathophysiology of T1D. We studied microbiota-mediated effects on disease progression in patients with type 1 diabetes using faecal…
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Artikel Jurnal
Effect of Vegan Fecal Microbiota Transplantation on Carnitine‐ and Choline‐Derived Trimethylamine‐N‐Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome
BackgroundIntestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the atherogenic metabolite TMAO (trimethylamine‐N‐oxide). Specifically, a vegan diet was associated with decreased plasma TMAO levels and nearly…
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Artikel Jurnal
Donor Fecal Microbiota Transplantation Alters Gut Microbiota and Metabolites in Obese Individuals With Steatohepatitis
The intestinal microbiota has been linked to the development and prevalence of steatohepatitis in humans. Interestingly, steatohepatitis is significantly lower in individuals taking a plant‐based, low‐animal‐protein diet, which is thought to be mediated by gut microbiota. However, data on causality…
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Artikel Jurnal
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome
Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. Methods: We…