24 hasil untuk "Arunkumar Krishnan"
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Artikel Jurnal
Reduced port laparoscopic repair of Bochdalek hernia in an adult: A first report
Bochdalek hernia is a congenital defect of the diaphragm that usually presents in the neonatal period with life-threatening cardiorespiratory distress. It is rare for Bochdalek hernias to remain silent until adulthood. A 57-year-old woman presented with history of difficulty in swallowing, as well…
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The Origin of GPCRs: Identification of Mammalian like Rhodopsin , Adhesion , Glutamate and Frizzled GPCRs in Fungi
G protein-coupled receptors (GPCRs) in humans are classified into the five main families named Glutamate, Rhodopsin, Adhesion, Frizzled and Secretin according to the GRAFS classification. Previous results show that these mammalian GRAFS families are well represented in the Metazoan lineages, but…
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Insights into the Origin of Nematode Chemosensory GPCRs: Putative Orthologs of the Srw Family Are Found across Several Phyla of Protostomes
Nematode chemosensory GPCRs in Caenorhabditis elegans (NemChRs) are classified into 19 gene families, and are initially thought to have split from the ancestral Rhodopsin family of GPCRs. However, earlier studies have shown that among all 19 NemChR gene families, only the srw family has a clear…
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The first identification of complete Eph-ephrin signalling in ctenophores and sponges reveals a role for neofunctionalization in the emergence of signalling domains
Abstract Background Animals have a greater diversity of signalling pathways than their unicellular relatives, consistent with the evolution and expansion of these pathways occurring in parallel with the origin of animal multicellularity. However, the genomes of sponges and ctenophores –…
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Unexpected Evolution of Lesion-Recognition Modules in Eukaryotic NER and Kinetoplast DNA Dynamics Proteins from Bacterial Mobile Elements
Summary: The provenance of several components of major uniquely eukaryotic molecular machines are increasingly being traced back to prokaryotic biological conflict systems. Here, we demonstrate that the N-terminal single-stranded DNA-binding domain from the anti-restriction protein ArdC, deployed…
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Artikel Jurnal Teks lengkap
Identification of Distant Agouti-Like Sequences and Re-Evaluation of the Evolutionary History of the Agouti-Related Peptide ( AgRP )
The Agouti-like peptides including AgRP, ASIP and the teleost-specific A2 (ASIP2 and AgRP2) peptides have potent and diverse functional roles in feeding, pigmentation and background adaptation mechanisms. There are contradictory theories about the evolution of the Agouti-like peptide family as well…
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Angiotensin-converting-enzyme inhibitors and risk of acute pancreatitis: a matched cohort study
Abstract Background Studies have reported inconsistent findings regarding the association between the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) and the risk of acute pancreatitis (AP). In this study we aimed to determine whether ACEis and ARBs…
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Artikel Jurnal Teks lengkap
Jumbo Phages: A Comparative Genomic Overview of Core Functions and Adaptions for Biological Conflicts
Jumbo phages have attracted much attention by virtue of their extraordinary genome size and unusual aspects of biology. By performing a comparative genomics analysis of 224 jumbo phages, we suggest an objective inclusion criterion based on genome size distributions and present a synthetic overview…
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Artikel Jurnal Teks lengkap
Use of Triplex PCR for Rapid Detection of PVL and Differentiation of MRSA from Methicillin Resistant Coagulase Negative Staphylococci
ABSTRACT Introduction: Methicillin-Resistant Staphylococcus aureus (MRSA) has become a major public health problem in both hospitals and communities. Panton – Valentine Leucocidin (PVL) has been reported to be an important marker for the highly pathogenic community acquired S. aureus infections. A…
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Macrovascular outcomes and mortality after bariatric surgery in patients with metabolic dysfunction–associated steatotic liver disease, and Type 2 diabetes
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, with a significant association between MASLD and Type 2 diabetes mellitus (T2DM), obesity, and cardiovascular disease (CVD). While bariatric surgery (BS) has…
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Proton pump inhibitors and all-cause mortality in colorectal cancer
Abstract Proton pump inhibitors (PPIs) are commonly prescribed medications, but their relationship to mortality in colorectal cancer (CRC) remains poorly understood. This study aims to evaluate the association between PPI use and all-cause mortality IN newly diagnosed CRC. This retrospective cohort…
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Adverse Liver and Renal Outcomes After Initiating SGLT‐2i and GLP‐1RA Therapy Among Patients With Diabetes and MASLD
ABSTRACT Context The management of metabolic dysfunction‐associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM) presents a significant clinical challenge, with a focus on preventing progression to liver and renal complications. Objective To evaluate the liver and renal…
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Artikel Jurnal
Awareness, Attitude and Practice during COVID-19 Pandemic among Non-Health Care Workers in a Tertiary Care Hospital in South India: A Cross Sectional Study
Introduction: To plan and implement effective control measures, knowledge about basic hygiene and the mechanism of disease transmission, and practices adopted in such circumstances is of utmost importance. Non-professional health care workers working in a tertiary care hospital is at a major risk…
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Impact of nonalcoholic fatty liver disease on clinical outcomes in patients with COVID-19 among persons living with HIV: A multicenter research network study
Background: People living with human immunodeficiency virus (PLWH) are at an increased risk of nonalcoholic fatty liver disease (NAFLD) but how these patients react to COVID-19 infection is unclear. We examined the clinical characteristics and outcomes of patients with and without nonalcoholic…
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Association between incretin-based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: A large population-based matched cohort study
Aim: To examine the association between the use of incretin-based drugs [glucagon-like peptide-1 receptor agonists (GLP-1RAs), dipeptidyl peptidase-4 inhibitors (DPP-4Is)] and the risk of cholangiocarcinoma (CCA) in the United States. Methods: This large population-based, retrospective cohort study…
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Artikel Jurnal
Risk of Severe Illness and Risk Factors of Outcomes of COVID-19 in Hospitalized Patients with Chronic Liver Disease in a Major U. S. Hospital Network
Background and Aim. Underlying comorbidities are an emerging risk factor for more severe coronavirus disease 2019 (COVID-19). However, its impact on patients with chronic liver disease (CLD) remains unclear. In addition, there is a paucity of data about whether patients with CLD have an increased…