13 results for "Dat T. Vo"

Simplified, standardized methods to assess the accuracy of clinical cancer staging

Dolly Y. Wu; Ann E. Spangler; Dat T. Vo et al.

Cancer Treatment and Research Communications, Vol. 25 · 2020 · English · DOAJ Scopus

Background: Hospitals lack intuitive methods to monitor their accuracy of clinical cancer staging, which is critical to treatment planning, prognosis, refinements, and registering quality data. Methods: We introduce a tabulation framework to compare clinical staging with the reference-standard…

The Musashi1 RNA-Binding Protein: A Critical Regulator in Glioblastoma

Dat T. Vo; Devraj Sandhu; Jonathan A. Gelfond et al.

Molecular Targets of CNS Tumors · 2011 · English · IntechOpen

3D printed integrated bolus/headrest for radiation therapy for malignancies involving the posterior scalp and neck

Eric J. Hsu; David Parsons; Tsuicheng Chiu et al.

3D Printing in Medicine, Vol. 8 No. 1 · 2022 · English · DOAJ Scopus

Abstract Background Malignancies of the head and neck region, encompassing cutaneous, mucosal, and sarcomatous histologies, are complex entities to manage, comprising of coordination between surgery, radiation therapy, and systemic therapy. Malignancies of the posterior scalp are particular…

miR-551a and miR-551b-3p target GLIPR2 and promote tumor growth in high-risk head and neck cancer by modulating autophagy

Narasimha Kumar Karanam; Lianghao Ding; Dat T. Vo et al.

Advances in Cancer Biology - Metastasis, Vol. 7 · 2023 · English · DOAJ Scopus

The potential role for microRNA (miRNA) in the metastatic process that occurs in head and neck squamous cell carcinoma (HNSCC) was examined. miRNA was extracted from surgically excised tumor samples from 41 HNSCC cancer patients diagnosed with distant metastasis (DM) and from 53 patients who…

miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer

Dat T. Vo; Narasimha Kumar Karanam; Lianghao Ding et al.

Neoplasia: An International Journal for Oncology Research, Vol. 21 No. 9 · 2019 · English · DOAJ Scopus

MicroRNAs (miRNAs) are short single-stranded RNAs, measuring 21 to 23 nucleotides in length and regulate gene expression at the post-transcriptional level through mRNA destabilization or repressing protein synthesis. Dysregulation of miRNAs can lead to tumorigenesis through changes in regulation of…

Genomic analyses of early responses to radiation in glioblastoma reveal new alterations at transcription, splicing, and translation levels

Saket Choudhary; Suzanne C. Burns; Hoda Mirsafian et al.

Scientific Reports, Vol. 10 No. 1 · 2020 · English · DOAJ Scopus

Abstract High-dose radiation is the main component of glioblastoma therapy. Unfortunately, radio-resistance is a common problem and a major contributor to tumor relapse. Understanding the molecular mechanisms driving response to radiation is critical for identifying regulatory routes that could be…

Socioeconomic and demographic determinants of radiation treatment and outcomes in glioblastoma patients

Eric J. Hsu; Jamie Thomas; Robert D. Timmerman et al.

Frontiers in Neurology, Vol. 13 · 2022 · English · DOAJ Scopus

IntroductionPoor outcomes in glioblastoma patients, despite advancing treatment paradigms, indicate a need to determine non-physiologic prognostic indicators of patient outcome. The impact of specific socioeconomic and demographic patient factors on outcomes is unclear. We sought to identify…

Impact of CDKN2A/B, MTAP, and TERT Genetic Alterations on Survival in IDH Wild Type Glioblastomas

Eric J. Hsu; Jamie Thomas; Elizabeth A. Maher et al.

Discover Oncology, Vol. 13 No. 1 · 2022 · English · DOAJ Scopus

Abstract Purpose Poor outcomes in IDH wild-type (IDHwt) glioblastomas indicate the need to determine which genetic alterations can indicate poor survival and guidance of patient specific treatment options. We sought to identify the genetic alterations in these patients that predict for survival…

Neutrophilia and post-radiation thrombocytopenia predict for poor prognosis in radiation-treated glioma patients

Eric J. Hsu; Jamie Thomas; Elizabeth A. Maher et al.

Frontiers in Oncology, Vol. 12 · 2022 · English · DOAJ Scopus

IntroductionPoor outcomes in glioma patients indicate a need to determine prognostic indicators of survival to better guide patient specific treatment options. While preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have…

Genomic Analyses Reveal Broad Impact of miR-137 on Genes Associated with Malignant Transformation and Neuronal Differentiation in Glioblastoma Cells

Saleh Tamim; Dat T. Vo; Philip J. Uren et al.

PLoS ONE, Vol. 9 No. 1 · 2014 · English · PLOS Scopus

miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mapping…

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RNA binding protein HuR regulates the expression of ABCA1[S]

Cristina M. Ramírez; Chin Sheng Lin; Kotb Abdelmohsen et al.

Journal of Lipid Research, Vol. 55 No. 6 · 2014 · English · DOAJ Scopus

ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA1 expression is poorly understood. Here, we investigate the potential contribution of the RNA…

T Stage and Pretreatment Standardized Uptake Values Predict Tumor Recurrence With 5-Fraction SABR in Early-Stage Non-Small Cell Lung Cancer

Eric J. Hsu, PhD; Jameson T. Mendel, MD; Kristin A. Ward, MD et al.

Advances in Radiation Oncology, Vol. 7 No. 5 · 2022 · English · DOAJ Scopus

Purpose: : Five-fraction stereotactic ablative radiotherapy (SABR) regimens are frequently used to treat centrally located early-stage non-small cell lung cancer or disease in the proximity of the chest wall as a means of optimizing tumor control and reducing treatment toxicity. However, increasing…