39 hasil untuk "David Azria"
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Artikel Jurnal
Personalizing Breast Cancer Irradiation Using Biology: From Bench to the Accelerator
While adjuvant treatments of early breast cancers (BCs) had significantly improved patients’ overall survival, some of them will still develop locoregional relapses and/or severe late radio-induced toxicities. Here, we propose to review how to personalize locoregional treatment by identifying…
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Artikel Jurnal
Management of the Axilla in the Era of Breast Cancer Heterogeneity
Systemic cancer therapies take into account breast cancer (BC) heterogeneity by targeting pathways specifically involved in some BC subtypes. On the other hand, BC intrinsic radiosensitivity is poorly understood and studied. Hence, radiotherapy personalization in BC is still “work in progress”. In…
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Artikel Jurnal
Different meaning of the mean heart dose between 3D-CRT and IMRT for breast cancer radiotherapy
BackgroundPrevious studies in 2D and in 3D conformal radiotherapy concludes that the maximal heart distance and the mean heart dose (MHD) are considered predictive of late cardiac toxicities. As the use of inverse-planned intensity modulated radiation therapy (IMRT) is increasing worldwide, we…
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Artikel Jurnal
Efficacy, safety, and feasibility of volumetric modulated arc therapy for synchronous bilateral breast cancer management
PurposeVolumetric Modulated Arc Therapy (VMAT) exhibits potent advantages regarding target volume coverage and protection of organs at risk, notably in the context of anatomical constraints. Nevertheless, reports concerning VMAT for the treatment of synchronous bilateral breast cancers (SBBC) have…
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Artikel Jurnal
Impact of the Siewert Classification on the Outcome of Patients Treated by Preoperative Chemoradiotherapy for a Nonmetastatic Adenocarcinoma of the Oesophagogastric Junction
The aim of the study is to analyze the impact of the Siewert classification on the pathological complete response (pcR), pattern of failure, and general outcome of patients treated, by preoperative chemoradiotherapy and surgery for an gastroesophageal junction adenocarcinoma (OGJA). From 2000 to…
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Artikel Jurnal
Robustness of radiomics features on 0.35 T magnetic resonance imaging for magnetic resonance-guided radiotherapy
Background and purpose: MR-guided radiotherapy adds the precision of magnetic resonance imaging (MRI) to the therapeutic benefits of a linear accelerator. Prior to each therapeutic session, an MRI generates a significant volume of imaging data ripe for analysis. Radiomics stands at the forefront of…
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Artikel Jurnal
Evaluation of Ethos intelligent optimization engine for left locally advanced breast cancer
PurposeTo evaluate the feasibility to use a standard Ethos planning template to treat left-sided breast cancer with regional lymph nodes.Material/MethodsThe tuning cohort of 5 patients was used to create a planning template. The validation cohort included 15 patients treated for a locally advanced…
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Artikel Jurnal
Self-learning GAN based synthetic CT generation: unlocking CBCT-based adaptive radiotherapy
Purpose/objectivesThis study proposes and clinically evaluates synthetic CT (sCT) images generated from multi-center CBCT scans using artificial intelligence, with the aim of fully leveraging CBCT for adaptive radiotherapy in patients with pelvic, head-and-neck, lung, and breast cancer.Materials…
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Artikel Jurnal
Feasibility study of adaptive radiotherapy with Ethos for breast cancer
PurposeThe aim of this study was to assess the feasibility of online adaptive radiotherapy with Ethos for breast cancer.Materials and methodsThis retrospective study included 20 breast cancer patients previously treated with TrueBeam. All had undergone breast surgery for different indications…
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Artikel Jurnal
Clinical feasibility of Ethos auto-segmentation for adaptive whole-breast cancer treatment
IntroductionFollowing a preliminary work validating the technological feasibility of an adaptive workflow with Ethos for whole-breast cancer, this study aims to clinically evaluate the automatic segmentation generated by Ethos.Material and methodsTwenty patients initially treated on a TrueBeam…
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Artikel Jurnal
Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity
Abstract Background Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conversely, proteomics approaches are not much developed, despite their…
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Artikel Jurnal
Association of polymorphisms in TGFB1, XRCC1, XRCC3 genes and CD8 T-lymphocyte apoptosis with adverse effect of radiotherapy for prostate cancer
Abstract The genetic background of each person might affect the severity of radiotherapy (RT)-induced normal tissue toxicity. The aim of study was to evaluate the influence of TGFB1 C-509T and Leu10Pro, XRCC1 Arg280His and XRCC3 Thr241Met polymorphisms as well as the level of radiation-induced CD8…
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Artikel Jurnal
Impact of discrimination on training and career of radiation oncologists in France
Purpose: In France, radiation oncologists are predominantly men with only 44 % of women. Many studies have highlighted gender disparities in medicine. The main objective of our study was to assess the impact of discriminations on radiation oncologists’ career. Materials and methods: An anonymous…
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Artikel Jurnal
In Pancreatic Carcinoma, Dual EGFR/HER2 Targeting with Cetuximab/Trastuzumab Is More Effective than Treatment with Trastuzumab/Erlotinib or Lapatinib Alone: Implication of Receptors' Down-regulation and Dimers' Disruption
We previously demonstrated the synergistic therapeutic effect of the cetuximab (anti-epidermal growth factor receptor [EGFR] monoclonal antibody, mAb)-trastuzumab (anti-HER2 mAb) combination (2mAbs therapy) in HER2low human pancreatic carcinoma xenografts. Here, we compared the 2mAbs therapy, the…
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Artikel Jurnal
Late Gastrointestinal Tolerance After Prostate Radiotherapy: Is the Anal Canal the Culprit? A Narrative Critical Review
IntroductionLate gastro-intestinal toxicities (LGIT) secondary to pelvic radiotherapy (RT) are well described in the literature. LGIT are mainly related to rectal or ano-rectal irradiation; however, involvement of the anal canal (AC) in the occurrence of LGIT remains poorly described and…
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Artikel Jurnal
Prospective results for 5-year survival and toxicity of moderately hypofractionated radiotherapy with simultaneous integrated boost (SIB) in (very) high-risk prostate cancer
Purpose: High-risk (HR) prostate cancer patients usually receive high-dose radiotherapy (RT) using a two-phase sequential technique, but data on a simultaneous integrated boost (SIB) technique are lacking. We prospectively evaluated the long-term results of urinary (GU) and digestive (GI) toxicity…
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Artikel Jurnal
Multi-centre technical evaluation of the radiation-induced lymphocyte apoptosis assay as a predictive test for radiotherapy toxicity
Predicting which patients will develop adverse reactions to radiotherapy is important for personalised treatment. Prediction will require an algorithm or nomogram combining clinical and biological data. The radiation-induced lymphocyte apoptosis (RILA) assay is the leading candidate as a biological…
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Artikel Jurnal
Magnetic Resonance–Guided Reirradiation for Local Recurrence Within the Prostate or in the Prostate Bed: Preliminary Results of a Prospective Registry Study
Purpose: This prospective registry study evaluated the feasibility of stereotactic magnetic resonance imaging (MRI)–guided radiation therapy for the local treatment of isolated prostate cancer recurrence within the gland or prostate bed after primary radiation therapy. Methods and Materials…
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Artikel Jurnal
Stereotactic MR-Guided Radiotherapy for Pancreatic Tumors: Dosimetric Benefit of Adaptation and First Clinical Results in a Prospective Registry Study
IntroductionStereotactic MR-guided adaptive radiotherapy (SMART) is an attractive modality of radiotherapy for pancreatic tumors. The objectives of this prospective registry study were to report the dosimetric benefits of daily adaptation of SMART and the first clinical results in pancreatic…