10 hasil untuk "Li-Li Gong"
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Artikel Jurnal
Relationship between hypothyroidism and the incidence of gestational diabetes: A meta-analysis
Objectives: Hypothyroidism disorders and gestational diabetes are among the most common endocrinopathies during pregnancy. We conducted a meta-analysis to investigate whether hypothyroidism in pregnancy is associated with gestational diabetes risk. Materials and methods: Published literature from…
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Artikel Jurnal
Investigating the shared genetic architecture between primary sclerosing cholangitis and inflammatory bowel diseases: a Mendelian randomization study
Abstract Background Several studies have found that primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) are closely associated. However, the direction and causality of their interactions remain unclear. Thus, this study employs Mendelian Randomization to explore whether there…
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Artikel Jurnal
Protective Effects of Akebia Saponin D Against Rotenone-Induced Hepatic Mitochondria Dysfunction
Abstract.: Akebia saponin D (ASD) is a typical bioactive triterpenoid saponin obtained from the rhizome of Dipsacus asper Wall. Previous studies have found that ASD has a hepatoprotective effect in a mouse model. The purpose of this paper was to explore the molecular mechanism of the…
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Artikel Jurnal
VDR Gene variation and insulin resistance related diseases
Abstract Background Vitamin D status may influence the risk of Insulin resistance related diseases such as Type 2 diabetes (T2DM), metabolic syndrome (MetS), and polycystic ovarian syndrome (PCOS). Several studies have assessed vitamin D receptor (VDR) gene polymorphism in relationship with these…
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Artikel Jurnal
Global burden of major gastrointestinal cancers and its association with socioeconomics, 1990–2019
BackgroundTo understand the impact of common cancers of the gastrointestinal tract and help to formulate evidence-based policy, we evaluate the relationship between the burden of GI tract cancers and socioeconomics.MethodsData on GI tract cancer burden were obtained from the Global Burden of…
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Artikel Jurnal Teks lengkap
Metalorganic chemical vapor deposition growth of InAs/GaSb type II superlattices with controllable As(x)Sb(1-x )interfaces
InAs/GaSb type II superlattices were grown on (100) GaSb substrates by metalorganic chemical vapor deposition (MOCVD). A plane of mixed As and Sb atoms connecting the InAs and GaSb layers was introduced to compensate the tensile strain created by the InAs layer in the SL. Characterizations of the…
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Artikel Jurnal
Mapping evolving care needs in older adults with disabilities: a qualitative study
Abstract To construct a patient journey map visualizing the dynamic care needs of older adults with moderate-to-severe disability, and to develop a dynamic assessment tool for clinical nursing practice. The population of older adults with moderate-to-severe disabilities is growing, presenting…
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Artikel Jurnal
Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy
Akebia Saponin D (ASD) is the most abundant constituent of the rhizome of Dipsacus asper Wall. The prior studies have shown that ASD alleviates hepatic steatosis targeted at the modulation of autophagy and exerts hepatoprotective effects through mitochondria. However, it is still unclear which…
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Artikel Jurnal
Advancing precision tacrolimus therapy: a systems genetics dissection in BXD platform
BackgroundTacrolimus is a core immunosuppressant in organ transplantation, but its narrow therapeutic window and significant pharmacokinetic variability hinder precision dosing. Although CYP3A5-guided strategies have established clinical relevance for tacrolimus initial dose adjustment, they do not…
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Artikel Jurnal
Akebia Saponin D Targeting Ubiquitin Carboxyl‐Terminal Hydrolase 4 Promotes Peroxisome Proliferator‐Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity
ABSTRACT Promoting thermogenesis in adipose tissue to enhance energy expenditure is widely regarded as a promising strategy for obesity treatment. However, the development of effective thermogenic drugs remains challenging. Our screenings identified the natural compound Akebia Saponin D (ASD) as a…