34 results for "Li-Wei Sun"

Development and evaluation of Desvenlafaxine loaded PLGA-chitosan nanoparticles for brain delivery

Gui-Feng Tong; Nan Qin; Li-Wei Sun

Saudi Pharmaceutical Journal, Vol. 25 No. 6 · 2017 · English · DOAJ Scopus

Depression is a debilitating psychiatric condition that remains the second most common cause of disability worldwide. Currently, depression affects more than 4 per cent of the world’s population. Most of the drugs intended for clinical management of depression augment the availability of…

A Novel Biochemical Study of Anti-Dermal Fibroblast Replicative Senescence Potential of Panax Notoginseng Oligosaccharides

Lu Zhai; Xiaohao Xu; Jiangzeng Liu et al.

Frontiers in Pharmacology, Vol. 12 · 2021 · English · DOAJ Scopus

Dermal fibroblast replicative senescence that often occurs in aging skin is characterized by loss of cell proliferative capacity, cell cycle arrest, decreased cell elongation, and decreased synthesis of dermal extracellular matrix (ECM) components. Although Panax notoginseng is known for its…

Detection of Bovine Milk Adulteration in Non-novine Milk Using Real-Time Polymerase Chain Reaction

LI Wei, SUN Guodong, LU Jiarong, ZHAO Zhongkai, YANG Jie

Shipin Kexue, Vol. 46 No. 6 · 2025 · Chinese · DOAJ Scopus

In this study, adulteration of bovine milk in fresh and thermally processed non-bovine milk was detected by SYBR Green and TaqMan real-time polymerase chain reaction (real-time PCR), and the effect of different heat treatment methods on the adulteration detection was explored aiming to meet the…

Ginseng-derived nanoparticles inhibit lung cancer cell epithelial mesenchymal transition by repressing pentose phosphate pathway activity

Lan Yang; Wen-qi Jin; Xiao-lei Tang et al.

Frontiers in Oncology, Vol. 12 · 2022 · English · DOAJ Scopus

It is unclear whether ginseng-derived nanoparticles (GDNPs) can prevent tumor cell epithelial-mesenchymal transition (EMT). Here, we describe typical characteristics of GDNPs and possible underlying mechanisms for GDNP antitumor activities. First, GDNPs particle sizes and morphology were determined…

Rapid Classification and Identification of Microcystis aeruginosa Strains Using MALDI–TOF MS and Polygenetic Analysis

Li-Wei Sun; Wen-Jing Jiang; Hiroaki Sato et al.

PLOS ONE, Vol. 11 No. 5 · 2016 · English · PLOS Scopus

Matrix-assisted laser desorption–ionization-time-of-flight mass spectrometry (MALDI–TOF MS) was used to establish a rapid, simple, and accurate method to differentiate among strains of Microcystis aeruginosa, one of the most prevalent types of bloom-forming cyanobacteria. M. aeruginosa NIES-843…

Also available at: DOAJ

Surgical outcomes of full endoscopic spinal surgery for lumbar disc herniation over a 10-year period: A retrospective study

Chien-Min Chen; Li-Wei Sun; Chun Tseng et al.

PLOS ONE, Vol. 15 No. 11 · 2020 · English · PLOS Scopus

Objective: Full endoscopic lumbar discectomy (FELD) for lumbar disc herniation (LDH) has become popular in recent years. Previous studies have proven the efficacy, but few have discussed the possible risk factors of poor outcome. In this study, we reviewed patients who underwent FELD at Changhua…

Also available at: DOAJ

Extraction and biodegradation of ginkgolic acids from Ginkgo biloba sarcotestae

Qi LI, Wei SUN, Yan JIANG, Fuliang CAO, Guibin WANG, Linguo ZHAO

Frontiers of Agricultural Science and Engineering, Vol. 4 No. 4 · 2017 · English · DOAJ

Ginkgolic acids are unwanted constituents in standard Ginkgo biloba leaves extracts. Thus, for the quality control of ginkgo extracts, it is important to establish an effective degradation method, with high catalytic efficiency and safety, to remove ginkgolic acids. Laccases are oxidases with…

Discovery of natural apigenin analogues as lysine-specific demethylase 1 inhibitors against tumoral testicular germ cells

Li-Wei Sun; Meng Zhang; Cai-Fang Li et al.

Scientific Reports, Vol. 16 No. 1 · 2026 · English · DOAJ Scopus

Abstract Testicular germ cell tumors (TGCT) pose a threat to men’s health, discovery of small molecule compounds with potent antiproliferative activity against testicular germ cells is of great significance. Lysine-specific demethylase 1 (LSD1) is overexpressed in tumoral testicular germ cell…

Analysis of Source Term and Radiation Dose in Fuel Handling Accident for Modular Small Pressurized Water Reactor

HEN Haiying;WANG Yichuan;HUANG Xuyang;LIU Qiaofeng;LI Wei;SUN Dawei

Yuanzineng kexue jishu, Vol. 56 No. 12 · 2022 · Chinese · DOAJ Scopus

Nuclear and Radiation Safety Center, Ministry of Ecology and Environment, Beijing 102401, China;Shanghai Nuclear Engineering Research & Design Institute Co., Ltd., Shanghai 200233, China

Discovery of a selective and reversible LSD1 inhibitor with potent anticancer effects in vitro and in vivo

Xiao-Song Zhang; Jin-Zhan Liu; Ying-Ying Mei et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 40 No. 1 · 2025 · English · DOAJ Scopus

Lysine-specific demethylase 1 (LSD1) is abnormally overexpressed in various tumour tissues of patients and has been an attractive anticancer target. In this work, a potent LSD1 inhibitor (compound 14) was designed and synthesised by the molecular hybridisation strategy. It displays the potent…

Full Endoscopic Removal of Cervical Spinal Epidural Abscess: Case Report and Technical Note

Kai-Sheng Chang; Li-Wei Sun; Chun-Yuan Cheng et al.

Neurospine, Vol. 17 No. Suppl 1 · 2020 · English · DOAJ Scopus

Spinal epidural abscess is a rare disease that is less likely to occur in the cervical region. When it occurs here, cervical spondylodiscitis can develop. Surgical treatment is recommended because of possible life-threatening septic and neurological complications. We present a case of an…

Acute toxicity and ecological risk assessment of 4,4’-dihydroxybenzophenone, 2,4,4’-trihydroxybenzophenone and 4-MBC in ultraviolet (UV)-filters

Jing Han; Ze-Tian Qin; Jing Zhang et al.

PLOS ONE, Vol. 16 No. 4 · 2021 · English · PLOS Scopus

Ultraviolet (UV) filters are used in cosmetics, personal care products and packaging materials to provide sun protection for human skin and other substances. Little is known about these substances, but they continue to be released into the environment. The acute toxicity of…

Transforaminal Endoscopic Lumbar Discectomy for L5–S1 Disc Herniation With High Iliac Crest: Technical Note and Preliminary Series

Kuo-Tai Chen; Sung-Tai Wei; Chun Tseng et al.

Neurospine, Vol. 17 No. Suppl 1 · 2020 · English · DOAJ Scopus

With the trend of minimally invasive spine surgery, full-endoscopic lumbar discectomy (FELD) has evolved with the advancement of the optics and instruments. Regarding the techniques, the transforaminal and interlaminar approach remain the major accesses in FELD. Transforaminal endoscopic lumbar…

Postoperative Pain Management after Full Endoscopic Lumbar Discectomy: An Observational Study

Guang-Xun Lin; Li-Wei Sun; Shang-Wun Jhang et al.

Medicina, Vol. 58 No. 12 · 2022 · English · DOAJ Scopus

Background: Surgical incision pain, rebound pain, and recurrence can manifest themselves in different forms of postoperative pain after full endoscopic lumbar discectomy (FELD). This study aims to evaluate various postoperative pains after FELD and summarize their characteristics. Methods: Data…

Intracranial anaplastic hemangiopericytoma with pulmonary metastases: one case report

Chun-hua MA; Xue-bin ZHANG; Rong JIANG et al.

Chinese Journal of Contemporary Neurology and Neurosurgery, Vol. 16 No. 2 · 2016 · Chinese · DOAJ Scopus

DOI: 10.3969/j.issn.1672-6731.2016.02.009

Ventriculoperitoneal shunt for brain displacement due to chronic subdural hematoma, using real-time navigated ventriculostomy by three-dimensional robotic C-arm: Technical note

Jae Hwan Lee; Kai-Sheng Chang; Su-wei Ou et al.

Interdisciplinary Neurosurgery, Vol. 31 · 2023 · English · DOAJ Scopus

Introduction: Ventriculoperitoneal (VP) shunts are widely used in the treatment of hydrocephalus. Optimal ventricular catheter (OVC) placement is required to reduce mechanical dysfunction, particularly when the lateral ventricle is deformed by other factors. We present a novel technique of VP shunt…

The distribution of subarachnoid and intraventricular hemorrhage on computed tomography suggests the location of an idiosyncratic vascular lesion

Li-Wei Sun; Che-Kuang Lin; Yi-Hsin Tsai et al.

Journal of Medical Sciences, Vol. 35 No. 4 · 2015 · English · DOAJ Scopus

The incidence of aneurysmal subarachnoid hemorrhage (SAH) associated with intraventricular hemorrhage (IVH) varies. In general, the anterior communicating artery and posterior circulation aneurysms cause such IVHs. A 48-year-old man visited the Neurosurgical Department for the evaluation of a…

Application of detecting cerebrospinal fluid circulating tumor cells in the diagnosis of meningeal metastasis of non-small cell lung cancer

Rong JIANG; Chun-hua MA; Zi-long ZHU et al.

Chinese Journal of Contemporary Neurology and Neurosurgery, Vol. 14 No. 8 · 2014 · Chinese · DOAJ Scopus

Objective To observe a new technology for the detection and enumeration of cerebrospinal fluid (CSF) circulating tumor cells (CTCs) in the diagnosis of non-small cell lung cancer (NSCLC) with meningeal metastasis (MM). Methods Five cases of NSCLC with MM that were diagnosed by CSF cytology were…