26 results for "Li-Ying Chen"
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Research on Influencing Factor of Hardware Trojan Side-channel Detection Method
The side-channel detection method screens the hardware Trojan circuit by collecting physical parameters such as power consumption,delay,and electromagnetic field,but its detection performance is seriously affected by process fluctuation,and process uncertainty increases as the chip process size…
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Study on Yield-Increase Model of Winter Wheat on Loess Rainfed Highland
In 1984-1986,two field experimentals of winter wheat with 3 fact- ors 5 levels of universal rotation design were carried out in Bucahang County of Shaanxi Province. Based on experimental results,a series of models had been establis- hed,which includes two main models:N fertilizer—P…
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Clinical Characteristics and Adverse Events in Acute Coronary Syndrome Patients with a History of Peripheral Arterial Disease
Abstract Background: In clinical observation, patients with acute coronary syndrome complicated with peripheral artery disease have poor prognosis, so the relationship between the diseases and clinical characteristics need to be further explored. Objective: This study aims to investigate clinical…
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Effectiveness comparison between ceftazidime-avibactam and carbapenem-based regimens in nosocomial carbapenem-resistant Klebsiella pneumoniae bloodstream infections
Background: Carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP BSI) are associated with high mortality rates and limited treatment options. This study compared the outcomes between ceftazidime-avibactam and carbapenem-based regimens in patients with nosocomial CRKP BSI…
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Fabrication of Pickering Emulsions Stabilized by Burdock Rhamnogalacturonan I (RG-1)-Type Pectin/Zein Composite Particles and Their Utilization for the Delivery of Curcumin
In the present work, Pickering emulsions were fabricated using burdock RG-1-type pectic polysaccharides/zein composite particles as emulsifiers. The effects of polysaccharide concentration, pH, ionic strength, and oil phase volume fraction (φ) on the physicochemical properties of the Pickering…
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Development of a Dual MOS Electronic Nose/Camera System for Improving Fruit Ripeness Classification
Electronic nose (E-nose) systems have become popular in food and fruit quality evaluation because of their rapid and repeatable availability and robustness. In this paper, we propose an E-nose system that has potential as a non-destructive system for monitoring variation in the volatile organic…
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Influence of acupuncture twisting parameters on analgesic effects mediated by mast cells in AA rat models
Acupuncture has been recognized for its potential effectiveness in pain relief without the side effects commonly associated with pharmaceutical treatments. This study investigates the effects of various acupuncture twisting parameters on analgesia using an acute adjuvant-induced arthritis (AA) rat…
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Stability of the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) and its isomers 2,4-diaminobutyric acid (DAB) and aminoethylglycine (AEG) in natural water
β-N-methylamino-L-alanine (BMAA) and its isomers, 2,4-diaminobutyric acid (2,4-DAB) and aminoethylglycine (AEG), are emerging cyanotoxins frequently detected in source water. While their monitoring and treatment have been studied, information on their stability in water remains lacking. This study…
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A robot arm-assisted acupuncture system with motion and force monitoring: establishment and validation
OBJECTIVE: Traditional manual acupuncture faces challenges in quantifying stimulation parameters and preserving techniques consistency. This study presents a robot arm-assisted acupuncture system replicating manual manipulations with precise motion and force monitoring. METHODS: System validation…
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Case report: primary resistance to osimertinib in erlotinib-pretreated lung adenocarcinoma with EGFR T790 M mutation
Abstract Background Among non-small cell lung cancer (NSCLC) patients with acquired T790 M mutation resistance to first-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), 71% are likely to benefit from osimertinib. There have been several reports about the secondary…
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A retrospective analysis of small molecule targeting inhibitor usage for lung cancer among outpatients in six major regions of China (2016–2022)
ObjectiveThis study aimed to evaluate national trends in amounts, prescription volumes, and the rationality of drug use in pharmacoeconomics associated with small molecule targeting inhibitors for lung cancer treatment among adult patients in China from 2016 to 2022.MethodsPrescription data for…
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The landscape of investigator‐initiated oncology trials conducted in mainland China during the past decade (2010–2019)
Abstract The number of clinical trials conducted in mainland China, including investigator‐initiated trials (IITs), has increased rapidly in recent years. However, there are few data on the characteristics of cancer‐related IITs. We performed a comprehensive analysis of the landscape of…
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Optimization of the Routine Approach for Label-Free Single-Cell Proteomics Using timsTOF Pro2 MS
Single-cell proteomics (SCP) aims to resolve protein heterogeneity among cells within tissue microenvironments. Single-cell proteomics analysis inherently relies on high-sensitivity mass spectrometry platforms. In this study, a series of optimizations for SCP analysis in a routine approach based on…
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Influence of acupuncture intensity on analgesic effects in AA rat models
OBJECTIVE: To investigate the influence of acupuncture lifting-thrusting frequency and amplitude on the analgesic effects, and its correlation with mast cell degranulation. METHODS: Acute adjuvant arthritis (AA) rat models were employed. Robot-arm aided lifting-thrusting acupuncture therapy was…
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A retrospective analysis of outpatient use of small-molecule targeted inhibitors for lymphoma across six regions of China (2016–2022)
ObjectiveThis study aimed to assess national trends in prescription volumes, drug expenditures, and the pharmacoeconomic rationality of small-molecule targeted inhibitors used for lymphoma treatment among outpatients in China between 2016 and 2022.MethodsOutpatient prescription data for patients…
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Association Between Stroke Risk and Metformin Use in Hemodialysis Patients With Diabetes Mellitus: A Nested Case–Control Study
BackgroundMetformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. Methods and ResultsUsing the National Health Insurance Research Database, we identified…
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Expression atlas of Dmrt genes across sex and development in the mouse brain: functional insights from the olfactory system
Abstract The ancient DMRT family of transcription factors has been proposed as evolutionarily conserved effectors of sexual differentiation. While brain sexual differentiation has traditionally been attributed to a paracrine role of steroid hormones and intrinsic cues directly controlled by sex…
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Effectiveness and safety of rivaroxaban versus warfarin in Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation: A real-world nationwide cohort study
Background: The optimal anticoagulant for end-stage renal disease patients for stroke prophylaxis is unknown. The efficacy and safety of warfarin in this population are debatable. In addition, real-world evidence of direct oral anticoagulants in patients with end-stage renal disease is limited. The…
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Palmitoyl Acyltransferase, Zdhhc13, Facilitates Bone Mass Acquisition by Regulating Postnatal Epiphyseal Development and Endochondral Ossification: A Mouse Model
ZDHHC13 is a member of DHHC-containing palmitoyl acyltransferases (PATs) family of enzymes. It functions by post-translationally adding 16-carbon palmitate to proteins through a thioester linkage. We have previously shown that mice carrying a recessive Zdhhc13 nonsense mutation causing a Zdhcc13…
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Risk Factors for Postischemic Stroke Epilepsy in Young Adults: A Nationwide Population-Based Study in Taiwan
BackgroundThe incidence of ischemic stroke has been increasing in the young population over the past 20 years. Poststroke epilepsy (PSE) is a common complication after stroke. However, few population-based studies with sufficient follow-up have investigated factors associated with PSE, especially…