12 hasil untuk "Li-juan Tang"
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Intraocular lymphoma
Intraocular lymphoma (IOL) is a rare lymphocytic malignancy which contains two main distinct forms. Primary intraocular lymphoma (PIOL) is mainly a sub-type of primary central nervous system lymphoma (PCNSL). Alternatively, IOL can originate from outside the central nervous system (CNS) by…
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Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits
ABSTRACT Cells rely on surface receptors to sense and initiate signalling cascades essential for numerous cellular processes, but engineering of synthetic genetic circuits to sense and rewire receptor activities for user‐defined cellular functions remains a challenge. Here we report a synthetic…
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2-(2-Chloro-3-quinolyl)-3-phenylthiazolidin-4-one
In the title compound, C18H13ClN2OS, the thiazolidinone ring is slightly distorted and adopts a envelope conformation. The basal plane is nearly perpendicular to the quinoline ring, forming a dihedral angle of 86.1 (1)°, and makes a dihedral angle of 14.9 (1)° to the benzene…
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Recent advances in the asymmetric catalytic construction of chiral indenols
Indenol scaffolds are ubiquitous and essential structural motifs prevalent in a wide array of pharmaceuticals and natural products, exhibiting notable biological activities. In recent years, considerable attention has been directed toward the development of novel synthetic methodologies for…
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t-SMILES: a fragment-based molecular representation framework for de novo ligand design
Abstract Effective representation of molecules is a crucial factor affecting the performance of artificial intelligence models. This study introduces a flexible, fragment-based, multiscale molecular representation framework called t-SMILES (tree-based SMILES) with three code algorithms: TSSA…
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Immunohistochemical features of carcinoma ex pleomorphic adenoma and pleomorphic adenoma in the lacrimal gland
AIM: To investigate C-myc, Ki-67, pan-cytokeratin, and vimentin immunohistochemical features of carcinoma ex pleomorphic adenoma (Ca-ex-PA) and pleomorphic adenoma (PA) in the lacrimal gland in order to find some clues in the differential diagnosis between them. METHODS: We reviewed microscopic…
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Expression of multidrug-resistance associated proteins in human retinoblastoma treated by primary enucleation
AIM: To reveal the expression of multidrug-resistance associated proteins: glutathione-S-transferase π (GSTπ), P-glycoprotein (P-gp) and vault protein lung resistance protein (LRP) in retinoblastoma (RB) without any conservative treatment before primary enucleation and to correlate this expression…
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The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia
Hematological malignancies possess a distinctive immunologic microenvironment compared with solid tumors. Here, using an established computational algorithm (CIBERSORT), we systematically analyzed the overall distribution of 22 tumor-infiltrating leukocyte (TIL) populations in more than 2000 bone…
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Yeasts from Nanfeng mandarin plants: occurrence, diversity and capability to produce indole-3-acetic acid
Plant growth promoters produced by microorganisms can play a significant role in the induction of some important physiological responses in the growth and development of plants. In this study, we provided a first insight into revealing the diversity of cultivable yeasts associated with Nanfeng…
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DOK6 promoter methylation serves as a potential biomarker affecting prognosis in de novo acute myeloid leukemia
Abstract Background Downstream of tyrosine kinase 6 (DOK6), which is specifically expressed in the nervous system, was previously recognized as an adapter only in neurite outgrowth. Recent studies also demonstrated the potential role of DOK6 in solid tumors such as gastric cancer and breast cancer…
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Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia
Abstract Background Leukemia stem cell (LSC)-enriched genes have been shown to be highly prognostic in acute myeloid leukemia (AML). However, the prognostic value of tumor suppressor genes (TSGs) that are repressed early in LSC remains largely unknown. Methods We compared the public available…
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Down-regulation of miR-29c is a prognostic biomarker in acute myeloid leukemia and can reduce the sensitivity of leukemic cells to decitabine
Abstract Background MicroRNA-29c (miR-29c) is abnormally expressed in several cancers and serves as an important predictor of tumor prognosis. Herein, we investigate the effects of abnormal miR-29c expression and analyze its clinical significance in acute myeloid leukemia (AML) patients. In…