13 hasil untuk "Lin Sun"
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Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism
ABSTRACT: Long-chain acyl-coenzyme A (CoA) synthase 4 (ACSL4) is an enzyme that esterifies CoA into specific polyunsaturated fatty acids, such as arachidonic acid and adrenic acid. Based on accumulated evidence, the ACSL4-catalyzed biosynthesis of arachidonoyl-CoA contributes to the execution of…
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The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases
Chronic inflammation plays an important role in the development of metabolic diseases. These include obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated fatty liver disease. The proinflammatory environment maintained by the innate immunity, including macrophages and related…
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Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu
BACKGROUND: The outbreak of novel coronavirus pneumonia (COVID-19) has brought enormous physical and psychological pressure on Chinese medical staff. It is extremely important to understand the prevalence and influencing factors of anxiety and depression symptoms in first-line anti-epidemic medical…
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The ChinaHighPM10 dataset: generation, validation, and spatiotemporal variations from 2015 to 2019 across China
Respirable particles with aerodynamic diameters ≤ 10 µm (PM10) have important impacts on the atmospheric environment and human health. Available PM10 datasets have coarse spatial resolutions, limiting their applications, especially at the city level. A tree-based ensemble learning model, which…
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Improved 1 km resolution PM 2.5 estimates across China using enhanced space–time extremely randomized trees
Fine particulate matter with aerodynamic diameters ≤2.5 µm (PM 2.5 ) has adverse effects on human health and the atmospheric environment. The estimation of surface PM 2.5 concentrations has made intensive use of satellite-derived aerosol products. However, it has been a great challenge to obtain…
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Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
Abstract Perfluoroalkyl substances (PFAS) are widely used in various manufacturing processes. Accumulation of these chemicals has adverse effects on human health, including inflammation in multiple organs, yet how PFAS are sensed by host cells, and how tissue inflammation eventually incurs, is…
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Ground-Level NO 2 Surveillance from Space Across China for High Resolution Using Interpretable Spatiotemporally Weighted Artificial Intelligence
High Resolution Image Download MS PowerPoint Slide Nitrogen dioxide (NO 2 ) at the ground level poses a serious threat to environmental quality and public health. This study developed a novel, artificial intelligence approach by integrating spatiotemporally weighted information into the missing…
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SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
Abstract Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood 1,2 . Dendritic cells (DCs), especially type-1 conventional DCs (cDC1s), mediate T cell priming and therapeutic efficacy against tumours 3 . DC functions are orchestrated…
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Black indium oxide a photothermal CO2 hydrogenation catalyst
Abstract Nanostructured forms of stoichiometric In 2 O 3 are proving to be efficacious catalysts for the gas-phase hydrogenation of CO 2 . These conversions can be facilitated using either heat or light; however, until now, the limited optical absorption intensity evidenced by the pale-yellow color…
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Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts
The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive understanding of their roles in IBD and their potential as reliable diagnostic biomarkers. To…
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Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals
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Artikel Jurnal Teks lengkap
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation