16 hasil untuk "Mahbuba Rahman"
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Artikel Jurnal
Metabolomics of infectious diseases in the era of personalized medicine
Infectious diseases continue to be a major cause of morbidity and mortality worldwide. Diseases cause perturbation of the host’s immune system provoking a response that involves genes, proteins and metabolites. While genes are regulated by epigenetic or other host factors, proteins can undergo…
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Artikel Jurnal Teks lengkap
Cancer Metabolism and Drug Resistance
Metabolic alterations, driven by genetic and epigenetic factors, have long been known to be associated with the etiology of cancer. Furthermore, accumulating evidence suggest that cancer metabolism is intimately linked to drug resistance, which is currently one of the most important challenges in…
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Artikel Jurnal Teks lengkap
Metabolomics in Infectious Diseases and Vaccine Response: Insights into Neglected Tropical and Non-Neglected Pathogens
Background/objectives: Metabolomics has emerged as a powerful systems-biology tool for deciphering dynamic metabolic alterations occurring during infectious diseases and following vaccination. While genomics and proteomics provide extensive molecular and regulatory information, metabolomics…
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Artikel Jurnal Teks lengkap
A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo.
SPARC, a matricellular protein with tumor suppressor properties in certain human cancers, was initially identified in a genome-wide analysis of differentially expressed genes in chemotherapy resistance. Its exciting new role as a potential chemosensitizer arises from its ability to augment the…
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Artikel Jurnal
Machine Learning based Model Reveals the Metabolites Involved in Coronary Artery Disease
Introduction: Coronary artery disease (CAD) is a major global cause of morbidity and mortality. Therefore, advances in early identification and individualized treatment plans are crucial. Methods: This article presents machine learning (ML) based model that can recognize metabolomic compounds…
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Artikel Jurnal
A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life [version 1; referees: 2 approved]
Compendia of large-scale datasets made available in public repositories provide an opportunity to identify and fill gaps in biomedical knowledge. But first, these data need to be made readily accessible to research investigators for interpretation. Here we make available a collection of…
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Artikel Jurnal
Encapsulation of mango peel bioactive compounds in milk, gum acacia, and maltodextrin improves its stability
There is an increased interest and need to make our economy more circular and our diets healthier and more sustainable. Mango peel is often discarded as waste after consuming mango pulp, despite its excellent source of bioactive compounds, especially phenolic compounds. The aim of this study was to…
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Artikel Jurnal
Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens
Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic, unbiased approach to explore the relative…
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Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo
Higher cyclooxygenase 2 (COX-2) expression is often observed in aggressive colorectal cancers (CRCs). Here, we attempt to examine the association between COX-2 expression in therapy-refractory CRC, how it affects chemosensitivity, and whether, in primary tumors, it is predictive of clinical…
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Artikel Jurnal Teks lengkap
Regional and Longitudinal Dynamics of Cyanobacterial Blooms/Cyanobiome and Cyanotoxin Production in the Great Lakes Area
Cyanobacteria (blue-green algae) are a diverse group of prokaryotic microorganisms that impact global biogeochemical cycles. Under eutrophic conditions, cyanobacterial species can produce cyanotoxins, resulting in harmful algal blooms (cHABs) that degrade water quality and result in economic and…
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Artikel Jurnal
Virome-wide serological profiling reveals association of herpesviruses with obesity
Abstract The relationship between viral infection and obesity has been known for several decades but epidemiological data is limited to only a few viral pathogens. The association between obesity and a wide range of viruses was assessed using VirScan, a pan-viral serological profiling tool. Serum…
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Artikel Jurnal
Bacteriophage and non-pathogenic Vibrio to control diseases in shrimp aquaculture
The study aimed to address the recurring outbreaks of microbial diseases in shrimp aquaculture in Bangladesh the study focused on the utilization of bacteriophages and non-pathogenic Vibrio. The bacteriophages were isolated from sewage water sample collected from shrimp farm, hatchery, and the JUST…
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Artikel Jurnal
Distinct antibody repertoires against endemic human coronaviruses in children and adults
Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory infection in humans. B cell responses to these “common cold” viruses remain incompletely understood. Here we report a comprehensive analysis of CoV-specific antibody repertoires in 231 children and 1168 adults…