14 hasil untuk "Mingjun Yu"
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Artikel Jurnal
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Neurological Complications
Our review aims to highlight the neurological complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the available treatments according to the existing literature, discussing the underlying mechanisms. Since the end of 2019, SARS-CoV-2 has induced a worldwide…
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Artikel Jurnal
The Effect of Application of Organic Substances Upon Soil Organic Matter
Results obtained from this experiment showed that the mineralized speeds of organic substances were Catte waste>Wheat straw>Corn stalk>Sweet clover in Huang Mian Soil and were Cattle waste>Corn stem>Wheat straw in Lou Soil. Humification coefficient of various organic substances incorporated into…
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Artikel Jurnal Teks lengkap
Design, Synthesis, Molecular Docking, and Anticancer Activity of Chalcone Derivatives as VEGFR-2 Inhibitors
A series of 4-phenylurea chalcones (2a–2s) as VEGFR-2 inhibitors has been designed, synthesized, and evaluated for in vitro cytotoxic activity against K562, SiHa, and B16 cancer cells. Compared to sorafenib, the compounds exhibited strong cytotoxicity against K562, SiHa and B16 cells. Compounds 2r…
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Artikel Jurnal
FKBP5 Exacerbates Impairments in Cerebral Ischemic Stroke by Inducing Autophagy via the AKT/FOXO3 Pathway
Cerebral ischemic stroke is regarded as one of the most serious diseases in the human central nervous system. The secondary ischemia and reperfusion (I/R) injury increased the difficulty of treatment. Moreover, the latent molecular regulating mechanism in I/R injury is still unclear. Based on our…
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Artikel Jurnal
LncRNA KCNQ1OT1 predicts further cerebral events in patients with transient ischemic attack
Transient ischemic attack (TIA) poses a great threat of cerebrovascular diseases to a large number of patients, despite its reversible neurological dysfunction. Long non-coding RNAs (lncRNAs) have been proven to play critical roles in the pathophysiological development of cerebrovascular events…
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Artikel Jurnal Teks lengkap
Design, Synthesis, and Evaluation of New 2-Arylpropanoic Acid-l-Tryptophan Derivatives for Mitigating Cisplatin-Induced Nephrotoxicity
Cisplatin (CIS) is a widely used chemotherapeutic agent that is highly effective against various cancers. However, its clinical application is frequently limited by its substantial nephrotoxic side effects. The gastrin-releasing peptide receptor (GRPR), a critical regulator in inflammatory…
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Artikel Jurnal Teks lengkap
Molecular Mechanistic Pathways Targeted by Natural Products in the Prevention and Treatment of Alcoholic Liver Disease
Alcoholic liver disease (ALD) is a condition caused by alcohol abuse. Although its incidence is rapidly increasing, effective treatments for this disease remain limited. The pathogenesis of ALD involves multiple aspects, such as direct damage from alcohol, oxidative stress, inflammation, lipid…
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Artikel Jurnal
MRI radiomics based on machine learning in high-grade gliomas as a promising tool for prediction of CD44 expression and overall survival
Abstract We aimed to predict CD44 expression and assess its prognostic significance in patients with high-grade gliomas (HGG) using non-invasive radiomics models based on machine learning. Enhanced magnetic resonance imaging, along with the corresponding gene expression and clinicopathological…
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Artikel Jurnal
Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair
BackgroundPercutaneous coronary intervention (PCI) remains the primary treatment for coronary artery disease (CAD), yet post-procedural arterial injury triggers cellular change and pathological inflammation, leading to thrombosis and restenosis. Recent studies have highlighted the chemokine CXCL2…
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Artikel Jurnal
Effect of boiling time on nutritional characteristics and antioxidant activities of Lentinus edodes and its broth
The influence of boiling time (10 –120 min) on nutritional and antioxidant properties of Lentinus edodes pieces and broth was investigated. The results showed that the primary nutrients contents and antioxidant activities of L. edodes pieces decreased with the prolongation of boiling time, while…
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Artikel Jurnal
Linc00152 promotes malignant progression of glioma stem cells by regulating miR-103a-3p/FEZF1/CDC25A pathway
Abstract Background Glioma is one of the most frequent intracranial malignant tumors. LncRNAs have been identified as new modulators in the origination and progression of glioma. Methods Quantitative real-time PCR were conducted to evaluate the expression of linc00152 and miRNA-103a-3p in glioma…
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Artikel Jurnal
Rheological and microstructural properties of wheat dough supplemented with Flammulina velutipes (mushroom) powder and soluble polysaccharides
Partial substitution of wheat flour with Flammulina velutipes powder (FVP) or soluble polysaccharide (SPFV) at different addition levels, and the effects of which on the rheological and microstructural properties of dough were investigated. FVP significantly (P < 0.05) increased the water…
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Artikel Jurnal
CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model
GABAergic signaling in the brain plays a key role in regulating synaptic transmission, neuronal excitability, and cognitive processes. Large-scale sequencing has revealed the diminished expression of GABA-related genes in Alzheimer's disease (AD), however, it is largely unclear about the epigenetic…