14 hasil untuk "Prolay Halder"
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Artikel Jurnal
SARS-CoV-2 variant dynamics and COVID-19 vaccine effectiveness during global epidemiological changes in mid-2025
Abstract As of mid-2025, the COVID-19 pandemic has transitioned into a complex endemic phase marked by ongoing viral evolution, heterogeneous population immunity, and regionally variable public health responses. SARS-CoV-2 continues to adapt through mutations primarily in the spike protein driven…
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Artikel Jurnal
Facile synthesis of multi-faceted, biomimetic and cross-protective nanoparticle-based vaccines for drug-resistant Shigella: a flexible platform technology
Abstract Background No commercial vaccines are available against drug-resistant Shigella due to serotype-specific/narrow-range of protection. Nanoparticle-based biomimetic vaccines involving stable, conserved, immunogenic proteins fabricated using facile chemistries can help formulate a…
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Artikel Jurnal
A newly developed oral infection mouse model of shigellosis for immunogenicity and protective efficacy studies of a candidate vaccine
ABSTRACT Shigella infection poses a significant public health challenge in the developing world. However, lack of a widely available mouse model that replicates human shigellosis creates a major bottleneck to better understanding of disease pathogenesis and development of newer drugs and vaccines…
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Artikel Jurnal
Controlling the bacterial load of Salmonella Typhi in an experimental mouse model by a lytic Salmonella phage STWB21: a phage therapy approach
Abstract Background Salmonella enterica serotype Typhi is one of the major pathogens causing typhoid fever and a public health burden worldwide. Recently, the increasing number of multidrug-resistant strains of Salmonella spp. has made this utmost necessary to consider bacteriophages as a potential…
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Artikel Jurnal
Quercetin, a flavonoid, combats rotavirus infection by deactivating rotavirus-induced pro-survival NF-κB pathway
Rotavirus (RV) is the leading cause of acute gastroenteritis and watery diarrhea in children under 5 years accounting for high morbidity and mortality in countries with poor socioeconomic status. Although vaccination against RV has been implemented in more than 100 countries, the efficacy of…
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Artikel Jurnal
Intranasal immunization of mice with chimera of Salmonella Typhi protein elicits protective intestinal immunity
Abstract Development of safe, highly effective and affordable enteric fever vaccines is a global health priority. Live, oral typhoid vaccines induce strong mucosal immunity and long-term protection, but safety remains a concern. In contrast, efficacy wears off rapidly for injectable…
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Artikel Jurnal
Sodium butyrate inhibits the expression of virulence factors in Vibrio cholerae by targeting ToxT protein
ABSTRACT Cholera, a diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, remains a global health threat in developing countries due to its high transmissibility and increased antibiotic resistance. There is a pressing need for alternative strategies, with an emphasis on…
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Artikel Jurnal
An Experimental Adult Zebrafish Model for Shigella Pathogenesis, Transmission, and Vaccine Efficacy Studies
ABSTRACT Shigellosis has been a menace to society for ages. The absence of an effective vaccine against Shigella, improper sanitation, and unhygienic use of food and water allow the disease to flourish. Shigella can also be transmitted via natural water bodies. In the absence of a good animal…
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Artikel Jurnal
Comparative immunogenicity and protective efficacy of BECC438 and BECC470 adjuvants in a vaccine formulation against Pseudomonas aeruginosa
The development of effective vaccines against the opportunistic pathogen Pseudomonas aeruginosa (Pa) remains a critical public health priority for susceptible individuals due, in part, to the pathogen’s intrinsic resistance mechanisms. This study evaluates the comparative immunogenicity and…
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Artikel Jurnal
Lactose fermenting enteroinvasive Escherichia coli from diarrhoeal cases confers enhanced virulence
Abstract Enteroinvasive Escherichia coli (EIEC), known for causing bacillary dysentery akin to Shigella species, comprises both lactose-fermenting (LF) and non-lactose-fermenting (NLF) isolates. While NLF-EIEC is a well-established pathogen associated with acute dysentery and harbours classical…
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Artikel Jurnal
Development of a bivalent protein subunit vaccine against infection by Pseudomonas aeruginosa and Staphylococcus aureus
Abstract Pseudomonas aeruginosa (PA) and Staphylococcus aureus (SA) are members of the ESKAPE pathogens, a group of bacteria that are a threat to human health due to their ability to resist antibiotics. They are known to cause severe infections, often as co-morbidities, in individuals with…
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Artikel Jurnal
Third-generation cephalosporin-induced L-form transition in Shigella sonnei reveals a virulence-survival trade-off underlying persistent infection
ABSTRACT Shigellosis remains a major global health burden, and the increasing prevalence of multidrug-resistant (MDR) Shigella strains is complicating effective antibiotic therapy. Bacteria may survive antibiotics by transitioning into cell wall-deficient L-forms, which are intrinsically resistant…