28 hasil untuk "Samir Abu-Rumeileh"
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Artikel Jurnal
Cerebrospinal Fluid and Blood Neurofilament Light Chain Protein in Prion Disease and Other Rapidly Progressive Dementias: Current State of the Art
Rapidly progressive dementia (RPD) is an umbrella term referring to several conditions causing a rapid neurological deterioration associated with cognitive decline and short disease duration. They comprise Creutzfeldt–Jakob disease (CJD), the archetypal RPD, rapidly progressive variants of the most…
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Artikel Jurnal
Longitudinal changes of blood β-synuclein in cognitively unimpaired, mild cognitive impairment and sporadic Alzheimer´s disease
Abstract Background β-Synuclein is an emerging synaptic blood biomarker for Alzheimer´s disease (AD) and correlates with cognitive impairment, brain atrophy and amyloid/tau pathology. Longitudinal data from individual patients are missing so far but are important to evaluate how changes of…
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Artikel Jurnal
Transverse Sinus Stenosis in Refractory Chronic Headache Patients: An Observational Study
Background: Transverse sinus stenosis is a common brain MRI finding in chronic migraine (CM) and chronic tension-type headache (CTTH) patients in clinical practice; however, its clinical and diagnostic role is unclear. The aim of the study is to determine the frequency of transverse sinus stenosis…
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Artikel Jurnal
Idiopathic Intracranial Hypertension Without Papilledema (IIHWOP) in Chronic Refractory Headache
Background: To determine the prevalence of Idiopathic intracranial hypertension without papilledema (IIHWOP) testing revised diagnostic criteria by Friedman in refractory chronic headache (CH) patients.Methods: This is a prospective observational study. Each patient underwent ophthalmologic…
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Artikel Jurnal Teks lengkap
CSF Ubiquitin Levels Are Higher in Alzheimer’s Disease than in Frontotemporal Dementia and Reflect the Molecular Subtype in Prion Disease
Disturbances in the ubiquitin-proteasome system seem to play a role in neurodegenerative dementias (NDs). Previous studies documented an increase of cerebrospinal fluid (CSF) free monoubiquitin in Alzheimer’s disease (AD) and Creutzfeldt−Jakob disease (CJD). However, to date, no study explored this…
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Artikel Jurnal
The CSF neurofilament light signature in rapidly progressive neurodegenerative dementias
Abstract Background Neurofilament light chain protein (NfL) is a surrogate biomarker of neurodegeneration that has never been systematically tested, either alone or in combination with other biomarkers, in atypical/rapidly progressive neurodegenerative dementias (NDs). Methods Using validated…
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Artikel Jurnal
CSF SerpinA1 in Creutzfeldt–Jakob disease and frontotemporal lobar degeneration
Abstract Objective SerpinA1 (alpha‐1 antitrypsin) is an acute inflammatory protein, which seems to play a role in neurodegeneration and neuroinflammation. In Alzheimer’s disease and synucleinopathies, SerpinA1 is overexpressed in the brain and the cerebrospinal fluid (CSF) showing abnormal patterns…
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Artikel Jurnal Teks lengkap
Blood GFAP as an emerging biomarker in brain and spinal cord disorders
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Artikel Jurnal
Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy
Abstract We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were…
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Artikel Jurnal
High diagnostic performance of plasma and cerebrospinal fluid beta‐synuclein for sporadic Creutzfeldt–Jakob disease
ABSTRACT Beta‐synuclein is a promising cerebrospinal fluid and blood biomarker of synaptic damage. Here we analysed its accuracy in the discrimination between sporadic Creutzfeldt–Jakob disease (n = 150) and non‐prion rapidly progressive dementias (n = 106). In cerebrospinal fluid, beta‐synuclein…
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Artikel Jurnal
CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia
Abstract Background In neurodegenerative dementias (NDs) such as prion disease, Alzheimer’s disease (AD), and frontotemporal lobar degeneration (FTLD), protein misfolding leads to the tissue deposition of protein aggregates which, in turn, trigger neuroinflammation and neurodegeneration…
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Artikel Jurnal Teks lengkap
Neurofilaments as biomarkers in neurological disorders — towards clinical application
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Artikel Jurnal
Aspiration, stent retriever, or combined approach for basilar artery occlusion: a three-way comparative analysis
Background: Basilar artery occlusion (BAO) is a rare but devastating form of ischaemic stroke, with high rates of disability and mortality. While randomized trials have demonstrated the benefit of mechanical thrombectomy (MT) in BAO, the optimal first-line technique – aspiration, stent retriever…
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Artikel Jurnal
Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke
Abstract We aimed to assess the prognostic value of serum β-synuclein (β-syn), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with moderate-to-severe acute ischemic stroke. We measured β-syn, GFAP and NfL in serum samples collected one day after admission in…
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Artikel Jurnal
Safety and Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke Attributable to Cardiological Diseases: A Scoping Review
There is limited evidence on the outcomes and safety of mechanical thrombectomy (MT) among patients with acute ischemic stroke (AIS) in the context of cardiac diseases. Our study reviews MT in AIS within the context of cardiac diseases, aiming to identify existing and emerging needs and gaps…
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Artikel Jurnal
Predictors of atrial fibrillation detection in embolic stroke of undetermined source patients with implantable loop recorder
BackgroundCovert atrial fibrillation (AF) is a predominant aetiology of embolic stroke of undetermined source (ESUS). Evidence suggested that AF is more frequently detected by implantable loop recorder (ILR) than by conventional monitoring. However, the predictive factors associated with occult AF…
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Artikel Jurnal
Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia
Background Decreased cerebrospinal fluid (CSF) levels of synaptic proteins, possibly reflecting impaired synaptic function, have been observed in major depressive disorder (MDD).Objective To investigate the diagnostic utility of the soluble N-ethylmaleimide-sensitive-factor attachment receptor…