25 results for "Shuting Han"

Coordinated multi-level adaptations across neocortical areas during task learning

Shuting Han; Fritjof Helmchen

Nature Communications, Vol. 16 No. 1 · 2025 · English · DOAJ Scopus

Abstract The coordinated changes of neural activity during learning, from single neurons to populations of neurons and their interactions across brain areas, remain poorly understood. To reveal specific learning-related changes, we applied multi-area two-photon calcium imaging in mouse neocortex…

Two-Color Volumetric Imaging of Neuronal Activity of Cortical Columns

Shuting Han; Weijian Yang; Rafael Yuste

Cell Reports, Vol. 27 No. 7 · 2019 · English · DOAJ Scopus

…multiplexing methods to easily boost imaging throughput. : In this work, Han et al. demonstrate two-color two-photon volumetric imaging of cortical neurons from layer 2–5 in vivo from more than 2,000 neurons at 10 vol/s. This scheme is compatible with many other imaging techniques, providing a new…

Comprehensive machine learning analysis of Hydra behavior reveals a stable basal behavioral repertoire

Shuting Han; Ekaterina Taralova; Christophe Dupre et al.

eLife, Vol. 7 · 2018 · English · DOAJ

Animal behavior has been studied for centuries, but few efficient methods are available to automatically identify and classify it. Quantitative behavioral studies have been hindered by the subjective and imprecise nature of human observation, and the slow speed of annotating behavioral data. Here…

Intratumoral microbiota: bidirectional modulation of tumor radiosensitivity

Fangfei Zhu; Shuting Han; Wenxiao Jia et al.

Frontiers in Immunology, Vol. 17 · 2026 · English · DOAJ Scopus

The term “intratumoral microbiota” refers to the microbial communities that reside within tumor tissues, including bacteria, fungi, mycoplasma, and viruses. Accumulating evidence indicates that the intratumoral microbiota is closely associated with tumor initiation and progression. Nevertheless…

Research Progress in Bile Acid Receptor-Mediated Improvement of Intestinal Health by Natural Products

LIU Qi, CHEN Siyang, HAN Xiaoqian, LI Shuting, HAN Feifei

Shipin Kexue, Vol. 47 No. 9 · 2026 · Chinese · DOAJ Scopus

Bile acids play an important role in intestinal health, and an imbalance in bile acid homeostasis is closely related to intestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, bile acid diarrhea, and colorectal cancer. Bile acids are synthesized by the liver and can be…

Oncology patients with pulmonary infiltrates in the COVID-19 era: a case series

Edwin Chong Yu Sng; Shuting Han; Valerie Shiwen Yang et al.

Singapore Medical Journal, Vol. 64 No. 10 · 2023 · English · DOAJ Scopus

Tailoring precision immunotherapy: coming to a clinic soon?

Shuting Han; Wai Ho Shuen; Who-Whong Wang et al.

ESMO Open, Vol. 5 No. Suppl 1 · 2020 · English · DOAJ Scopus

IM-Dedup: An Image Management System Based on Deduplication Applied in DWSNs

Jilin Zhang; Shuting Han; Jian Wan et al.

International Journal of Distributed Sensor Networks, Vol. 9 · 2013 · English · DOAJ Scopus

In distributed wireless sensor networks (DWSNs), the data gathered by sink is always massive and consumes a lot of resources. It is suitable for cloud computing platform to apply service in data processing system. In cloud computing, IAAS platform provides services and calculation to the user…

Decoding tinnitus progression: neurochemical shifts in the anterior cingulate cortex revealed by magnetic resonance spectroscopy

Mengfang Gong; Shuting Han; Yongcong Shen et al.

Frontiers in Neuroscience, Vol. 19 · 2025 · English · DOAJ Scopus

BackgroundTinnitus persists as a significant public health challenge with elusive neurochemical underpinnings. Emerging evidence implicates dysregulated excitatory-inhibitory neurotransmission in the anterior cingulate cortex (ACC), a limbic-auditory hub governing tinnitus salience. This study…

Fermentation of Green Tea Extract by Streptococcus thermophilus FUA329 and Evaluation of Storage Characteristics

Shuting HAN; Ziyan HUA; Yaowei FANG et al.

Shipin gongye ke-ji, Vol. 45 No. 21 · 2024 · Chinese · DOAJ Scopus

In order to evaluate the effect of Streptococcus thermophilus fermentation on green tea extract and its storage characteristics, this study used Streptococcus thermophilus FUA329 and S. thermophilus ST1.8748 (control group) to conduct experiments on green tea extracts. After fermentation and…

Resting-State Functional Connectivity Analyses: Brain Functional Reorganization in a Rat Model of Postherpetic Neuralgia

Shuting Han; Guanzuan Wu; Xiang Wei et al.

Brain Sciences, Vol. 12 No. 8 · 2022 · English · DOAJ Scopus

Postherpetic neuralgia (PHN) is a chronic neuropathic pain syndrome, similar to other chronic pains, the mechanisms of which are not fully understood. To further understand the neural mechanism of this chronic pain and its transition, we performed functional magnetic resonance imaging (fMRI) scans…

Association of salvage radiotherapy with survival outcomes in extracranial oligoprogression after first-line therapy for extensive-stage small-cell lung cancer: a multicenter retrospective cohort study

Jiatong Li; Shuting Han; Xiaoyang Zhai et al.

Therapeutic Advances in Medical Oncology, Vol. 18 · 2026 · English · DOAJ Scopus

Background: While first-line systemic therapy is the standard of care for extensive-stage small-cell lung cancer (ES-SCLC), therapeutic failure remains nearly universal, with survival heavily dictated by progression patterns. Extracranial oligoprogression represents a distinct treatment failure…

Spatiotemporal Characteristics and Influencing Factors of PM2.5 Levels in Lianyungang: Insights from a Multidimensional Analysis

Xue Li; Haihong He; Dewei Wang et al.

Remote Sensing, Vol. 16 No. 23 · 2024 · English · DOAJ Scopus

The rapid industrialization and urbanization in China have exacerbated air pollution, particularly PM2.5, posing significant threats to public health. This study focused on Lianyungang, an industrial city, to analyze the spatiotemporal variations in PM2.5 concentrations from 2000 to 2023 and…

Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3B +/- male mice

Maria Helena Bortolozzo-Gleich; Guillaume Bouisset; Lan Geng et al.

Nature Communications, Vol. 16 No. 1 · 2025 · English · DOAJ Scopus

Abstract The neuropeptide arginine-vasopressin (AVP) has been repeatedly associated with the autism spectrum disorder (ASD) but the underlying mechanisms remain unclear. As Shank3B +/- male mice, a model of ASD, exhibit deficits in sociability and social aggression, we focused on the lateral septum…

Pathogenesis and therapeutic implications of EBV-associated epithelial cancers

Yi Hua Low; Celestine Jia Ling Loh; Daniel Yang Yao Peh et al.

Frontiers in Oncology, Vol. 13 · 2023 · English · DOAJ Scopus

Epstein-Barr virus (EBV), one of the most common human viruses, has been associated with both lymphoid and epithelial cancers. Undifferentiated nasopharyngeal carcinoma (NPC), EBV associated gastric cancer (EBVaGC) and lymphoepithelioma-like carcinoma (LELC) are amongst the few common epithelial…

Oncology workload in a tertiary hospital during the COVID-19 pandemic

Jianbang Chiang; Valerie Yang; Shuting Han et al.

Proceedings of Singapore Healthcare, Vol. 31 · 2022 · English · DOAJ Scopus

Introduction Workload in oncology during a pandemic is expected to increase as manpower is shunted to other areas of need in combating the pandemic. This increased workload, coupled with the high care needs of cancer patients, can have negative effects on both healthcare providers and their…

Epstein–Barr Virus Epithelial Cancers—A Comprehensive Understanding to Drive Novel Therapies

Shuting Han; Joshua K. Tay; Celestine Jia Ling Loh et al.

Frontiers in Immunology, Vol. 12 · 2021 · English · DOAJ Scopus

Epstein–Barr virus (EBV) is a ubiquitous oncovirus associated with specific epithelial and lymphoid cancers. Among the epithelial cancers, nasopharyngeal carcinoma (NPC), lymphoepithelioma-like carcinoma (LELC), and EBV-associated gastric cancers (EBVaGC) are the most common. The role of EBV in the…

Developmental Cajal-Retzius cell death contributes to the maturation of layer 1 cortical inhibition and somatosensory processing

Angeliki Damilou; Linbi Cai; Ali Özgür Argunşah et al.

Nature Communications, Vol. 15 No. 1 · 2024 · English · DOAJ Scopus

Abstract The role of developmental cell death in the formation of brain circuits is not well understood. Cajal-Retzius cells constitute a major transient neuronal population in the mammalian neocortex, which largely disappears at the time of postnatal somatosensory maturation. In this study, we…

Impact of cancer diagnoses on the outcomes of patients with COVID-19: a systematic review and meta-analysis

Shuting Han; Qingyuan Zhuang; Jianbang Chiang et al.

BMJ Open, Vol. 12 No. 2 · 2022 · English · DOAJ Scopus

The distinct clinical trajectory, metastatic sites, and immunobiology of microsatellite-instability-high cancers

Shuting Han; Aik Yong Chok; Daniel Yang Yao Peh et al.

Frontiers in Genetics, Vol. 13 · 2022 · English · DOAJ Scopus

Microsatellite-instability-high (MSI-H) cancers form a spectrum of solid organ tumors collectively known as Lynch Syndrome cancers, occurring not only in a subset of colorectal, endometrial, small bowel, gastric, pancreatic, and biliary tract cancers but also in prostate, breast, bladder, and…