21 hasil untuk "Yu-Ping Lin"
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Artikel Jurnal
Chiral flat band superconductivity from symmetry-protected three-band crossings
We show that chiral (nearly) flat band superconductivity can develop and host novel Majorana fermions at a time-reversal pair of symmetry-protected three-band crossing points. Based on symmetry analysis, mean-field study, and superfluid stiffness calculation, we determine and analyze the…
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Complex charge density waves at Van Hove singularity on hexagonal lattices: Haldane-model phase diagram and potential realization in the kagome metals AV3Sb5 ( A =K, Rb, Cs)
The recent discovery of topological charge density waves in the superconducting kagome metals $A$V${}_{3}$Sb${}_{5}$ ($A$=K, Rb, Cs) has attracted enormous attention. Motivated by the experiments, the authors analyze here the interplay of real and imaginary charge density waves at the Van Hove…
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Chern dartboard insulator: sub-Brillouin zone topology and skyrmion multipoles
Abstract Topology plays a crucial role in many physical systems, leading to interesting states at the surface. A paradigmatic example is the Chern number defined in the Brillouin zone that leads to robust gapless edge states. Here we introduce the reduced Chern number, defined in the subregions of…
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Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters
Endoplasmic reticulum Ca2+ sensing STIM proteins and plasma membrane Orai1 channels together regulate Ca2+ influx in eukaryotic cells. Here authors show that two Ca2+-dependent transcription factors, NFAT1 and c-fos, have different requirements for the number of STIM1-Orai1 clusters and on the Ca2+…
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Screening, identification, and anti-alcoholic and anti-drunken efficacy evaluation of ethanol-degrading lactic acid bacteria
Lactic acid bacteria were isolated from milk pimple (traditional fermented food) samples by traditional culture separation method, and the strains with high ethanol degradation function were screened by ethanol degradation test in vitro, and were identified by morphological observation…
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The alleviating effect of Scutellaria amoena extract on the regulation of gut microbiota and its metabolites in NASH rats by inhibiting the NLRP3/ASC/caspase-1 axis
Background:Scutellaria amoena (SA) is the root of S. amoena C.H. Wright of Labiatae, also known as Scutellaria southwestern. This is mainly distributed in Sichuan, Yunnan, and Guizhou in China. In southwest China, SA is used as an alternative method to genuine medicine for the treatment of allergy…
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Correlation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017–2018
Abstract Background Prevalence rates of hyperuricemia and gout are increasing. Clinical investigations of hyperuricemia-related risk factors aid in the early detection, prevention, and management of hyperuricemia and gout. Ongoing research is examining the association of obesity, dietary patterns…
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Activation of nuclear Ca2+-dependent gene expression by CRAC channel Ca2+ nanodomains
Summary: Oscillations in the levels of second messengers are observed throughout the phylogenetic tree, with signaling information encoded in the frequency of the spikes. Different biological targets respond to different frequencies of oscillation, leading to the concept of frequency counting. The…
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L-type calcium channel blockers at therapeutic concentrations are not linked to CRAC channels and heart failure
Amlodipine has been used as a front-line anti-hypertensive therapy for decades by virtue of blocking voltage-operated calcium channels with high affinity and specificity. Recently, the safety of amlodipine has been questioned, as it was reported to activate Ca2+ release-activated Ca2+ (CRAC)…
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Effects of coping on nurses' mental health during the COVID‐19 pandemic: Mediating role of social support and psychological resilience
Abstract Background Fighting against the COVID‐19 pandemic, front‐line nurses were under unprecedented psychological pressure. Therefore, it is necessary to promptly evaluate the psychological status of nurses during the COVID‐19 epidemic period. Aim To investigate nurses' mental health during the…
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Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63
Strobilanthes cusia (Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. The methanol extract of S. cusia leaf contains chemical components such as β-sitosterol, indirubin, tryptanthrin, betulin, indigodole A, and indigodole B that have diverse…
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Flavonoid-containing supplements for preventing acute respiratory tract infections: A systematic review and meta-analysis of 20 randomized controlled trials
Background: This systematic review and meta-analysis was conducted to investigate the efficacy and safety of flavonoid-containing supplements in preventing acute respiratory tract infection (ARTI). Methods: Randomized controlled trials (RCTs) investigating the effects of flavonoid-containing…
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Interplay between SIN3A and STAT3 Mediates Chromatin Conformational Changes and GFAP Expression during Cellular Differentiation
Background: Neurons and astrocytes are generated from common neural precursors, yet neurogenesis precedes astrocyte formation during embryogenesis. The mechanisms of neural development underlying suppression and de-suppression of differentiation- related genes for cell fate specifications are not…
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AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels
Abstract To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca2+ nanodomain is a spatially confined signal that arises near open Ca2+ channels. Ca2+ nanodomains near store-operated Orai1 channels stimulate the protein phosphatase…
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Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
Background: SARS-CoV-2 has led to a sharp increase in the number of hospitalizations and deaths from pneumonia and multiorgan disease worldwide; therefore, SARS-CoV-2 has become a global health problem. Supportive therapies remain the mainstay treatments against COVID-19, such as oxygen inhalation…
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Flavonoids for Treating Viral Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis of 30 Randomized Controlled Trials
BackgroundThis meta-analysis aimed to investigate the efficacy and safety of flavonoids in treating viral acute respiratory tract infections (ARTIs).MethodsRandomized controlled trials (RCTs) were entered into meta-analyses performed separately for each indication. Efficacy analyses were based on…
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Efficacy of flavonoids-containing supplements on insulin resistance and associated metabolic risk factors in overweight and obese subjects: a systematic review and meta-analysis of 25 randomized controlled trials
BackgroundObesity is becoming a global epidemic. Flavonoids, with anti-inflammatory and antioxidative functions, are proposed to treat insulin resistance (IR) in obese subjects. We aimed to evaluate the effectiveness and safety of flavonoids-containing supplements on IR and associated metabolic…
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A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children
Abstract Dyslexia and developmental language disorders are important learning difficulties. However, their genetic basis remains poorly understood, and most genetic studies were performed on Europeans. There is a lack of genome-wide association studies (GWAS) on literacy phenotypes of Chinese as a…
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Hypofractionated radiotherapy for refractory or relapsed aggressive B-cell lymphoma in the rituximab era
Abstract Background Radiotherapy (RT) is an effective and available local treatment for patients with refractory or relapsed (R/R) aggressive B-cell lymphomas. However, the value of hypofractionated RT in this setting has not been confirmed. Methods We retrospectively analyzed patients with R/R…