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Journal Article
Integrating artificial intelligence in energy transition: A comprehensive review
The global energy transition, driven by the imperative to mitigate climate change, demands innovative solutions to address the technical, economic, and social challenges of decarbonization. Artificial intelligence (AI) has emerged as a transformative technology in this domain, offering tools to…
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A Focused Update to the Clinical Practice Guidelines for the Prevention and Management of Pain, Anxiety, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
RATIONALE: Critically ill adults are at risk for a variety of distressing and consequential symptoms both during and after an ICU stay. Management of these symptoms can directly influence outcomes. OBJECTIVES: The objective was to update and expand the Society of Critical Care Medicine's 2018…
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Endometriosis
Importance: Endometriosis is a chronic, estrogen-dependent, inflammatory disease defined by endometrial-like tissue (lesions) outside the uterine lining. It affects up to 10% of women worldwide, and 9 million women in the US, during reproductive years. Observations: Endometriosis has varying…
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🧜Siren’s Song in the AI Ocean: A Survey on Hallucination in Large Language Models
Abstract While large language models (LLMs) have demonstrated remarkable capabilities across a range of downstream tasks, a significant concern revolves around their propensity to exhibit hallucinations: LLMs occasionally generate content that diverges from the user input, contradicts previously…
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BindingDB Entry 50022503: A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
The Met receptor tyrosine kinase has been shown to be overexpressed or mutated in a variety of solid tumors and has, therefore, been identified as a good candidate for molecularly targeted therapy. Activation of the Met tyrosine kinase by the TPR gene was originally described in vitro through…
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Emerging role of exosomes in cancer therapy: progress and challenges
This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple cancer types. As small extracellular vesicles, exosomes exhibit high biocompatibility and low immunogenicity…
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Segment Anything for Microscopy
Accurate segmentation of objects in microscopy images remains a bottleneck for many researchers despite the number of tools developed for this purpose. Here, we present Segment Anything for Microscopy (μSAM), a tool for segmentation and tracking in multidimensional microscopy data. It is based on…
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Extracellular matrix stiffness: mechanisms in tumor progression and therapeutic potential in cancer
Tumor microenvironment (TME) is a complex ecosystem composed of both cellular and non-cellular components that surround tumor tissue. The extracellular matrix (ECM) is a key component of the TME, performing multiple essential functions by providing mechanical support, shaping the TME, regulating…
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Ethical and legal considerations in healthcare AI: innovation and policy for safe and fair use
Artificial intelligence (AI) is transforming healthcare by enhancing diagnostics, personalizing medicine and improving surgical precision. However, its integration into healthcare systems raises significant ethical and legal challenges. This review explores key ethical principles-autonomy…
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Clinician Experiences With Ambient Scribe Technology to Assist With Documentation Burden and Efficiency
Importance: Timely evaluation of ambient scribing technology is warranted to assess whether this technology can lessen the burden of clinical documentation on clinicians. Objective: To investigate the association of ambient scribing technology with efficiency, quality, and perceived burden of…
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fastp 1.0: An ultra‐fast all‐round tool for FASTQ data quality control and preprocessing
Fastp has been recognized as one of the most popular FASTQ file preprocessors because of its powerful functions and extreme performance. As its first major update, fastp 1.0 will be formally presented in this paper, including its new features and the implementation principles behind it. Two other…
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Large Language Models for Chatbot Health Advice Studies
Importance: There is much interest in the clinical integration of large language models (LLMs) in health care. Many studies have assessed the ability of LLMs to provide health advice, but the quality of their reporting is uncertain. Objective: To perform a systematic review to examine the reporting…
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Invasion and metastasis in cancer: molecular insights and therapeutic targets
The progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting their quality of life and survival rates. Research efforts…
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A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX
Randomized controlled trials (RCTs) are the gold standard for evaluating the efficacy and safety of both pharmacological and non-pharmacological interventions. However, while they are designed to control confounders and ensure internal validity, their usually stringent inclusion and exclusion…
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High-entropy alloy enables multi-path electron synergism and lattice oxygen activation for enhanced oxygen evolution activity
Electrocatalytic oxygen evolution reaction (OER) is key to several energy technologies but suffers from low activity. Leveraging the lattice oxygen activation mechanism (LOM) is a strategy for boosting its activity. However, this approach faces significant thermodynamic challenges, requiring…
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Prevalence of Depression and Anxiety Among Adults With Chronic Pain
Importance: Depression and anxiety are common among adults with chronic pain, but their prevalence is unclear. Objectives: To evaluate the prevalence of depression and anxiety among adults with chronic pain and identify factors that moderate prevalence. Data Sources: A literature search was…
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Activation of lysosomal iron triggers ferroptosis in cancer
Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death called ferroptosis1. Defining where this chemistry occurs in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Genetic…
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Ultra-processed foods and human health: the main thesis and the evidence
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Mechanisms of oxidative stress-induced sperm dysfunction
Oxidative stress plays a pivotal role in male infertility by impairing sperm function through various molecular mechanisms. This review explores the impact of excessive reactive oxygen species (ROS) on spermatozoa, particularly focusing on lipid peroxidation, DNA fragmentation, and protein…
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