37 results for "Boxuan LI"
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Journal Article
Identification and functional characterization of de novo variant in the SYNGAP1 gene causing intellectual disability
Background: Intellectual disability (ID) is defined by cognitive and social adaptation defects. Variants in the SYNGAP1 gene, which encodes the brain-specific cytoplasmic protein SYNGAP1, are commonly associated with ID. The aim of this study was to identify novel SYNGAP1 gene variants in Chinese…
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Journal Article Full text
Growing Tibetan Pigs Adapt to High-Fiber Diets by Enhancing Fiber Degradation Capacity
The systematic analysis of the synergistic mechanism between microbial fiber-degrading enzymes and short-chain fatty acids under high-fiber diet conditions is limited. In this study, we evaluated the effects of a high-fiber diet on the growth performance, nutrient digestibility, blood and serum…
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Journal Article
Spatial analysis of commuting carbon emissions in main urban area of Beijing: A GPS trajectory-based approach
Commuting carbon emissions (CCE) constitute a significant portion of urban carbon emissions and exert a notable influence on urban land use policies and spatial planning strategies. Traditional methods for estimating CCEs have many disadvantages and are less accurate in terms of space and time. In…
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Journal Article
Heterogeneous temporal representation for diabetic blood glucose prediction
Background and aims: Blood glucose prediction (BGP) has increasingly been adopted for personalized monitoring of blood glucose levels in diabetic patients, providing valuable support for physicians in diagnosis and treatment planning. Despite the remarkable success achieved, applying BGP in…
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Journal Article
pH-sensitive and bubble-generating mesoporous silica-based nanoparticles for enhanced tumor combination therapy
Chemotherapy has been a major option in clinic treatment of malignant tumors. However, single chemotherapy faces some drawbacks, such as multidrug resistance, severe side effects, which hinder its clinic application in tumor treatment. Multifunctional nanoparticles loading with chemotherapeutic…
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Journal Article
Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis
Abstract Injectable hydrogel implants represent a promising therapeutic approach for ischemic heart failure; but their efficacy is often limited by low bioactivity, poor durability, and inadequate injection techniques. Herein, a unique hydrogel incorporating extracellular matrix from fish swim…
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Journal Article
Revealing the Neuroimaging Mechanism of Acupuncture for Poststroke Aphasia: A Systematic Review
Background. Aphasia is a common symptom in stroke patients, presenting with the impairment of spontaneous speech, repetition, naming, auditory comprehension, reading, and writing function. Multiple rehabilitation methods have been suggested for the recovery of poststroke aphasia, including…
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Journal Article
Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
Abstract Resveratrol (RSV) acts either as an antioxidant or a pro-oxidant depending on contexts. RSV-treated cancer cells may experience replication stress that can lead to cellular senescence or apoptosis. While both oxidative and replication stresses may mediate the anti-proliferation effect of…
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Journal Article
Manipulating hyperbolic transient plasmons in a layered semiconductor
Abstract Anisotropic materials with oppositely signed dielectric tensors support hyperbolic polaritons, displaying enhanced electromagnetic localization and directional energy flow. However, the most reported hyperbolic phonon polaritons are difficult to apply for active electro-optical modulations…
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Journal Article
Integrative analysis of the gut microbiota, bile acid pathways, and immune dysregulation in dyslipidemia models
Summary: Emerging evidence suggests a link between gut microbiota, bile acid metabolism, and immune dysregulation in dyslipidemia. Through a case-control study involving 140 participants and an animal experiment, we identified significantly elevated counts of peripheral blood CD3+ T cells, CD4+ T…
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Journal Article Full text
MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise
Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration of atrophic status, there is no effective mediator available for treatment and the underlying cellular mechanisms are less explored. In…
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Journal Article
Membrane curvature governs the distribution of Piezo1 in live cells
This study demonstrates that the curvature of the cell membrane directly regulates the spatial distribution of Piezo1, a widely expressed mechanosensitive ion channel. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics
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Journal Article
How is the quality of randomized controlled trials (RCTs) for acupuncture treatment of post-stroke aphasia? A report quality assessment.
ObjectiveThis study aimed to assess the quality of randomized controlled trials (RCTs) that have reported the use of acupuncture for the treatment of post-stroke aphasia (PSA).MethodsWe systematically searched PubMed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge…
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Journal Article
The efficacy and safety of acupuncture combined with language training for motor aphasia after stroke: study protocol for a multicenter randomized sham-controlled trial
Abstract Background Motor aphasia after stroke is a common and intractable complication of stroke. Acupuncture and language training may be an alternative and effective approach. However, the efficacy of acupuncture and language training for motor aphasia after stroke has not been confirmed. The…
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Journal Article
Effect of acupuncture on ischemic stroke patients with hypertension: a randomized clinical trail
BackgroundLimited evidence suggests that acupuncture has a short-term antihypertensive effect. The efficacy and safety of acupuncture as an adjunctive treatment for ischemic stroke patients with hypertension were uncertain.ObjectiveTo investigate the efficacy and safety of acupuncture as adjunctive…
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Journal Article
Understanding the robustness of vision-language models to medical image artefacts
Abstract Vision-language models (VLMs) show promise for answering clinically relevant questions, but their robustness to medical image artefacts remains unclear. We evaluated VLMs’ robustness through their performance on images with and without weak artefacts across five artefact categories, as…