17 results for "Keyi Fan"
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Journal Article
Nationwide spatiotemporal patterns of aortic aneurysm mortality and temperature-related risk in the United States (1999–2023)
BACKGROUND: Although aortic aneurysm (AA) mortality has declined in recent decades, contemporary nationwide evidence in the United States and the potential impact of ambient temperature on AA mortality remain limited. METHODS: We analyzed AA mortality among individuals aged ≥25 years in the United…
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Journal Article Full text
Design and Optimization of Broadband Optical Half-Band Filters Based on Cascaded MZIs
In optical communication systems, optical half-band filters are essential for efficient spectral separation, necessitating stringent performance criteria such as a wide spectral range, low insertion loss, and minimal crosstalk. This paper proposes a broadband optical half-band filter based on a…
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Journal Article
Hemodynamics and matrix stiffness shape the pathogenicity of SPP1+ macrophages
BackgroundMacrophages exhibit significant plasticity and are integral to tissue homeostasis and disease progression. Recent single-cell RNA sequencing (scRNA-seq) analyses identify secreted phosphoprotein 1-positive (SPP1+) macrophages as a highly conserved pathogenic subpopulation. This subset…
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Journal Article
Association of birth weight with type 2 diabetes mellitus and the mediating role of fatty acids traits: a two-step mendelian randomization study
Abstract Background Observational studies have suggested an association between birth weight and type 2 diabetes mellitus, but the causality between them has not been established. We aimed to obtain the causal relationship between birth weight with T2DM and quantify the mediating effects of…
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Journal Article
Identification and validation of hub genes related to neutrophil extracellular traps-mediated cell damage and immune recruitment during abdominal aortic aneurysm
Abstract Previous research has shown that the formation of Neutrophil Extracellular Traps (NETs), mediated by neutrophils, leads to an increase in inflammatory cell response and cellular tissue damage during Abdominal Aortic Aneurysm (AAA). Building on this foundation, our primary objective is to…
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Journal Article
Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy
Abstract Diabetic nephropathy (DN) is one of the major causes of end-stage renal disease. This study aimed to explore the internal relationship between metabolic processes and autoimmune responses in patients with DN via untargeted metabolomics and Olink proteomics. The serum of 10 patients who…
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Journal Article
Olink proteomics reveals TNFRSF9 as a biomarker for abdominal aortic aneurysms
Summary: Abdominal aortic aneurysm (AAA) is a serious cardiovascular disease associated with chronic inflammation. The purpose of this study was to use the Olink proteomics to reveal serum inflammatory markers in AAA. We examined the expression levels of 92 inflammation-related proteins in patients…
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Journal Article
Genetic associations between ULK3 and epilepsy: a two-sample Mendelian randomization study
Background and objectivesObservational studies have suggested that a multitude of pathological processes and biomolecules are involved in the initiation and development of epilepsy, and ULK3 is linked to the nervous system. However, it remains uncertain whether this association between ULK3 and…
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Journal Article
Highly sensitive magnetic particle imaging of abdominal aortic aneurysm NETosis with anti-Ly6G iron oxide nanoparticles
Abstract Abdominal aortic aneurysms (AAA) are a significant health concern in developed countries due to their considerable mortality rate. The crucial factor of the progression of AAA is the release of neutrophils and neutrophil extracellular traps (NETs). Magnetic particle imaging (MPI) is a new…
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Journal Article
Global landscape of mortality and risk factors for aortic aneurysm in adults aged 55 years and older: insights from the global burden of disease study 2021
The incidence and mortality rates of aortic aneurysm have been rising globally, particularly among the elderly. The aim of this study is to investigate the global patterns, temporal trends, risk factors, and future burden of aortic aneurysm in the elderly. This study analyzed trends in the burden…
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Journal Article
Enhanced electrocatalytic performance for H2O2 generation by boron-doped porous carbon hollow spheres
Summary: Electrocatalytic generation of H2O2 via the 2-electron pathway of oxygen reduction reaction (2e-ORR) is an attractive technology compared to the anthraquinone process due to convenience and environmental friendliness. However, catalysts with excellent selectivity and high activity for…
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Journal Article
Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway
Abstract Background Atherosclerosis (AS) is a persistent inflammatory condition triggered and exacerbated by several factors including lipid accumulation, endothelial dysfunction and macrophages infiltration. Nobiletin (NOB) has been reported to alleviate atherosclerosis; however, the underlying…
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Journal Article
Noninvasive monitoring of vascular alterations in mice with acute lower limb ischemia using multimodal photoacoustic imaging
Abstract Acute limb ischemia (ALI), especially acute lower limb ischemia (ALLI), is a common clinical vascular emergency with high amputation and mortality rates. However, major challenges exist in rapidly diagnosing and assessing collateral vascular compensatory capacity, leading to appropriate…
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Journal Article
Global Epidemiology of Early-Onset Aortic Aneurysm: Temporal Trends, Risk Factors, and Future Burden Projections
Abstract Background Aortic aneurysm has a subtle onset, high rupture mortality, rapid progression in younger individuals, and increasing annual mortality rates. Our study aimed to estimate the global burden and trends of early-onset aortic aneurysm from 1990 to 2021. Methods Participants aged 15–39…
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Journal Article
Genetically predicted the causal relationship between gut microbiota and the risk of polymyositis/dermatomyositis: a Mendelian randomization analysis
IntroductionObservational studies suggest associations between gut microbiota and polymyositis (PM) and dermatomyositis (DM), but causal relationships are unclear. We investigate the causal effects of gut microbiota on PM and DM, providing insights hoping to provide insights for future treatment…
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Journal Article
Impact of kidney dysfunction on outcomes in peripheral artery disease: A multi-database cohort study
Summary: Peripheral artery disease (PAD) and kidney dysfunction frequently coexist, worsening clinical outcomes. This study aimed to clarify the relationship between PAD and kidney dysfunction, including their co-occurrence, impact on outcomes, and potential causal links. Analyzing GBD 2021 data…