20 results for "Keyun Wang"
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Journal Article
Starch branching enzymes as putative determinants of postharvest quality in horticultural crops
Abstract Starch branching enzymes (SBEs) are key determinants of the structure and amount of the starch in plant organs, and as such, they have the capacity to influence plant growth, developmental, and fitness processes, and in addition, the industrial end-use of starch. However, little is known…
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Severe cutaneous adverse reactions and their association with autoimmune disease: an update
Severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP), are T-cell-mediated hypersensitivity reactions. Although their…
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Heterogeneous Layout-Aware Cross-Modal Knowledge Point Classification for Exam Questions
With the continuous emergence of exam question types, accurate classification of knowledge points is crucial for intelligent exam analysis. Existing methods focus on text or text–image fusion but largely ignore spatial layout. To address this limitation, we propose a heterogeneous layout-aware…
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Molecular basis for protein histidine N1-specific methylation of the “His-x-His” motifs by METTL9
Histidine methylation serves as an intriguing strategy to introduce altered traits of target proteins, including metal ion chelation, histidine-based catalysis, molecular assembly, and translation regulation. As a newly identified histidine methyltransferase, METTL9 catalyzes N1-methylation of…
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Concentrations and Species of Mercury in Municipal Sludge of Selected Chinese Cities and Potential Mercury Emissions From Sludge Treatment and Disposal
Municipal sewage has been identified as an important source of mercury (Hg) to the environment, and sewage sludge is the major sink of sewage-borne Hg. Knowledge of Hg species in sludge and potential Hg emissions during sludge treatment/disposal is still limited. A survey on Hg concentrations and…
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Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells
Abstract Comprehensive knowledge of drug targets, their binding efficacy, and the subsequent activated cellular pathways is critical for determining therapeutic efficacy, elucidating mechanisms of action, and identifying potential side effects. However, acquiring this information in living cells…
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Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells
Metformin had exerted important inhibitory effects in multiple cancers. However, the correlation between metformin and hepatocellular carcinoma (HCC) metastasis, and the relevant mechanisms are still unclear. By quantitative proteomics analysis technique, we found metformin could suppress FGF…
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Effects of daily mean temperature and other meteorological variables on bacillary dysentery in Beijing-Tianjin-Hebei region, China
Background: Although previous studies have shown that meteorological factors such as temperature are related to the incidence of bacillary dysentery (BD), researches about the non-linear and interaction effect among meteorological variables remain limited. The objective of this study was to analyze…
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Machine learning model for cardiovascular disease prediction in patients with chronic kidney disease
IntroductionCardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). This study aimed to develop CVD risk prediction models using machine learning to support clinical decision making and improve patient prognosis.MethodsElectronic medical records…
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Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques
VRC01 protects macaques from vaginal SHIV infection after a single high-dose challenge. Infusion of a simianized anti-α4β7 mAb (Rh-α4β7) just prior to, and during repeated vaginal exposures to SIVmac251 partially protected macaques from vaginal SIV infection and rescued CD4+ T cells. To investigate…
Also available at: DOAJ
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Journal Article
The risk of acute and early HIV (AEH) infection among MSM with different behaviour trajectories: an open cohort study in Tianjin, China, 2011–2019
Abstract Background Acute and early HIV (AEH) infection is characterized by a high viral load and infectivity. Approximately 50% of cases of HIV-1 transmission occur during AEH. Understanding sexual behaviour trajectories would be useful for predicting changes in the risk of HIV acquisition…
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Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers
Abstract Protein methylation is a functionally important post-translational modification that occurs on diverse amino acid residues. The current proteomics approaches are inefficient to discover the methylation on residues other than Arg and Lys, which hinders the deep understanding of the…
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Cross-sectional study on the relationship between sarcopenia indicators and lung function in a community-dwelling population
BackgroundWith advancing age, multiple systems, including the muscular and respiratory systems, undergo degenerative changes. While the relationship between sarcopenia and lung function is well-established in patients with respiratory diseases, evidence remains limited in the general population…
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A machine learning model based on routine blood-derived indices for early arterial stiffness prediction in the community
Abstract Background Increased arterial stiffness is a high-risk factor for cardiovascular diseases, making its early identification crucial. Based on data from an apparently healthy community-based population, this study employed machine learning algorithms to screen for factors influencing early…
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Validity and applicability of the global leadership initiative on malnutrition criteria in non-dialysis patients with chronic kidney disease
IntroductionThere are no standardized assessment criteria for selecting nutritional risk screening tools or indicators to assess reduced muscle mass (RMM) in the Global Leadership Initiative on Malnutrition (GLIM) criteria. We aimed to compare the consistency of different GLIM criteria with…
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Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective…
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Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody
Summary: Highly effective HIV-1-neutralizing antibodies could have utility in the prevention or treatment of HIV-1 infection. To improve the potency of 10E8, an antibody capable of near pan-HIV-1 neutralization, we engineered 10E8-surface mutants and screened for improved neutralization. Variants…