26 hasil untuk "Matthieu Prot"

Integrated Proteomic and Transcriptomic Investigation of the Acetaminophen Toxicity in Liver Microfluidic Biochip

Jean Matthieu Prot; Anne-Sophie Briffaut; Franck Letourneur dkk.

PLoS ONE, Vol. 6 No. 8 · 2011 · Inggris · PLOS Scopus

Microfluidic bioartificial organs allow the reproduction of in vivo-like properties such as cell culture in a 3D dynamical micro environment. In this work, we established a method and a protocol for performing a toxicogenomic analysis of HepG2/C3A cultivated in a microfluidic biochip…

Juga tersedia di: DOAJ

First detection of one of the tick-borne lymphadenopathy (TIBOLA) etiological agent in ticks from a highly frequented sub-urban forest near Paris, France

Eva A. Krupa; Laurine Levillayer; Matthieu Prot dkk.

PLOS Global Public Health, Vol. 6 No. 1 · 2026 · Inggris · PLOS Scopus

In the context of global changes including climate, environmental and socio-economic modifications, the surveillance of tick populations in term of species distribution and harboured pathogens is an absolute necessity. With this aim in view, ticks were collected in May 2022 in an highly frequented…

Juga tersedia di: DOAJ

A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice

Claude Roth; Tineke Cantaert; Chloé Colas dkk.

Frontiers in Immunology, Vol. 10 · 2019 · Inggris · DOAJ Scopus

Dengue virus (DENV) induces strong T and B cell responses upon infection. Hence, it is difficult to determine the contribution of cell-mediated immunity alone in the long lasting protection against DENV infection and disease. Numerous CD4+ and CD8+ T cell epitopes have been identified, mainly in…

Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes[S]

Srijana Ranjit; Emilie Boutet; Pallavi Gandhi dkk.

Journal of Lipid Research, Vol. 52 No. 2 · 2011 · Inggris · DOAJ Scopus

The lipid droplet-associated fat specific protein 27 (FSP27) suppresses lipolysis and thereby enhances triglyceride accumulation in adipocytes. We and others have recently found FSP27 to be a remarkably short-lived protein (half-life, 15 min) due to its rapid ubiquitination and proteasomal…

Combining PCR and Metagenomic Approaches to Reveal Tick-Borne Pathogens in Ticks Collected from Livestock and Companion Animals in Cambodia

Sony Yean; Didot Budi Prasetyo; Sovanncheypo Chao dkk.

Pathogens, Vol. 15 No. 6 · 2026 · Inggris · DOAJ Scopus

In Cambodia, livestock production plays an important role in the national economy and food security, yet tick-borne diseases remain an underrecognized constraint on animal health and productivity. Domestic animals may also serve as reservoirs of zoonotic pathogens in this predominantly rural…

Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015–2018

Fabiana Gámbaro; Ana Belén Pérez; Eduardo Agüera dkk.

Scientific Reports, Vol. 11 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract New circulating Enterovirus (EV) strains often emerge through recombination. Upsurges of recombinant non-polio enteroviruses (NPEVs) associated with neurologic manifestations such as EVA71 or Echovirus 30 (E30) are a growing public health concern in Europe. Only a few complete genomes of…

Author Correction: Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015–2018

Fabiana Gámbaro; Ana Belén Pérez; Eduardo Agüera dkk.

Scientific Reports, Vol. 11 No. 1 · 2021 · Inggris · DOAJ Scopus

Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus

Shiho Torii; Jennifer S. Lord; Morgane Lavina dkk.

Nature Communications, Vol. 16 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Zika virus (ZIKV) is a mosquito-borne orthoflavivirus primarily transmitted among humans by Aedes aegypti. Over the past two decades, it has caused significant outbreaks associated with birth defects and neurological disorders. ZIKV consists of two main genotypes: the African and Asian…

Escape of SARS-CoV-2 Variants KP.1.1, LB.1, and KP.3.3 From Approved Monoclonal Antibodies

Delphine Planas; Isabelle Staropoli; Cyril Planchais dkk.

Pathogens and Immunity, Vol. 10 No. 1 · 2024 · Inggris · DOAJ Scopus

Background: First-generation anti-SARS-CoV-2 monoclonal antibodies (mAbs) used for prophylaxis or therapeutic purposes in immunocompromised patients have been withdrawn because of the emergence of resistant Omicron variants. In 2024, 2 novel mAbs, VYD222/Pemivibart and AZD3152/Sipavibart, were…

Viral evolution sustains a dengue outbreak of enhanced severity

Catherine Inizan; Marine Minier; Matthieu Prot dkk.

Emerging Microbes and Infections, Vol. 10 No. 1 · 2021 · Inggris · DOAJ Scopus

Compared to the previous 2013–2014 outbreak, dengue 2016–2017 outbreak in New Caledonia was characterized by an increased number of severe forms associated with hepatic presentations. In this study, we assessed the virological factors associated with this enhanced severity. Whole-genome sequences…

Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion

Delphine Planas; Isabelle Staropoli; Vincent Michel dkk.

Nature Communications · 2024 · Inggris · OpenAlex Scopus

The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral sublineages. Here, we isolate and characterize XBB.1, XBB.1.5, XBB.1.9.1, XBB.1.16.1, EG.5.1.1, EG.5.1.3, XBF, BA.2.86.1 and JN.1 variants, representing >80% of circulating variants in January 2024. The XBB…

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

Timothée Bruel; Jérôme Hadjadj; Piet Maes dkk.

Nature Medicine · 2022 · Inggris · OpenAlex Scopus

A novel SARS-CoV-2 related coronavirus in bats from Cambodia

Deborah Delaune; Vibol Hul; Erik A. Karlsson dkk.

Nature Communications, Vol. 12 No. 1 · 2021 · Inggris · DOAJ Scopus

In this study, Delaune et al., isolate and characterise a SARS-CoV-2-related coronavirus from two bats sampled in Cambodia. Their findings suggest that the geographic distribution of SARS-CoV-2-related viruses is wider than previously reported.

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas; David L. Veyer; Artem Baidaliuk dkk.

Nature · 2021 · Inggris · OpenAlex Scopus

Molecular Characterization of Dengue Type 2 Outbreak in Pacific Islands Countries and Territories, 2017–2020

Catherine Inizan; Olivia O’Connor; George Worwor dkk.

Viruses, Vol. 12 No. 10 · 2020 · Inggris · DOAJ Scopus

Dengue virus (DENV) serotype-2 was detected in the South Pacific region in 2014 for the first time in 15 years. In 2016–2020, DENV-2 re-emerged in French Polynesia, Vanuatu, Wallis and Futuna, and New Caledonia, co-circulating with and later replacing DENV-1. In this context, epidemiological and…

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

Delphine Planas; Timothée Bruel; Ludivine Grzelak dkk.

Nature Medicine · 2021 · Inggris · OpenAlex Scopus

Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies

Delphine Planas; Timothée Bruel; Isabelle Staropoli dkk.

Nature Communications, Vol. 14 No. 1 · 2023 · Inggris · DOAJ Scopus

In this work, Planas et al. report that Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 escape neutralization from monoclonal antibodies, and sera from vaccinated individuals with or without Omicron BA.1/2 or BA.5 breakthrough infection.

Characterization and evolutionary history of novel SARS-CoV-2-related viruses in bats from Cambodia

Tey Putita Ou; Julia Guillebaud; Artem Baidaliuk dkk.

Nature Communications, Vol. 17 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Circulating bat coronaviruses present a significant pandemic threat, yet our understanding of their genetic diversity and evolutionary dynamics remains limited. Over 3 years, we sampled 1,462 bats in Cambodia’s Steung Treng province, identifying extensive and diverse coronaviruses…