16 results for "Moubin Lin"

The value of chromosome instability detected by low−pass whole−genome sequencing in preoperative prediction of sentinel lymph node metastasis in breast cancer

Jian Zheng; Fen Xu; Guangying Li et al.

Frontiers in Oncology, Vol. 14 · 2024 · English · DOAJ Scopus

BackgroundBreast cancer is a malignancy characterized by chromosomal instability (CIN). This study aimed to examine the potential diagnostic value of chromosomal instability, detected by low-pass whole-genome sequencing (LPWGS), in the preoperative evaluation of sentinel lymph node metastasis…

CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy

Liyan Gong; Kaihua Wang; Mengcheng Wang et al.

Frontiers in Cell and Developmental Biology, Vol. 9 · 2021 · English · DOAJ Scopus

p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, cell death, and survival. Therefore, it is implicated in human diseases such as obesity and cancer. Here, we show that the CUL5–ASB6 complex is a ubiquitin E3…

Collagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression

Kang Lin; Yun Zhao; Yuqi Tang et al.

Cell Death and Disease, Vol. 15 No. 1 · 2024 · English · DOAJ Scopus

Abstract The global burden of colorectal cancer (CRC) has rapidly increased in recent years. Dysregulated cholesterol homeostasis facilitated by extracellular matrix (ECM) remodeling transforms the tumor microenvironment. Collagen I, a major with ECM component is highly expressed in colorectal…

Cholesterol synthases suppress metastasis and stemness through PDIA4/ACLY or SYVN1/SCD1 axis in advanced colorectal cancer

Wenjie Li; Moubin Lin; Yun Zhao et al.

Communications Biology, Vol. 9 No. 1 · 2026 · English · DOAJ Scopus

Abstract Aberrant cholesterol biosynthesis is a notable hallmark of cancers, supporting unlimited cell proliferation. Previously, we delineated that cholesterol synthases FDFT1 and SQLE promoted colorectal cancer (CRC) cell proliferation, while how these enzymes influence CRC metastasis and…

Dynamic remodelling of epithelial plasticity in colorectal cancer from single-cell and spatially resolved perspectives

Chengyuan Xu; Yun Pan; Siqi Zhang et al.

Journal of Translational Medicine, Vol. 23 No. 1 · 2025 · English · DOAJ Scopus

Abstract Background Epithelial compartments play a central role in the progression and metastasis of colorectal cancer (CRC), yet the mechanisms underlying their transcriptional reprogramming across disease stages remain incompletely understood. Methods We constructed comprehensive single-cell and…

Sleeve gastrectomy attenuates high fat diet-induced non-alcoholic fatty liver disease

Erli Pei; Yang Liu; Weiqing Jiang et al.

Lipids in Health and Disease, Vol. 17 No. 1 · 2018 · English · DOAJ Scopus

Abstract Background A high-fat diet (HFD) is known to lead to obesity, and contributes to the progression of non-alcoholic fatty liver disease. The objective of this study was to evaluate the effects of sleeve gastrectomy (SG) on the progression of HFD-induced hepatic steatosis. Methods Fifteen…

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling

Luwei He; Huaguang Li; Chenyu Pan et al.

Cancer Communications, Vol. 41 No. 8 · 2021 · English · DOAJ Scopus

Abstract Background Colorectal cancer (CRC) is one of the most malignant tumors with high incidence, yet its molecular mechanism is not fully understood, hindering the development of targeted therapy. Metabolic abnormalities are a hallmark of cancer. Targeting dysregulated metabolic features has…

Risk Factors for Distant Metastasis in T3 T4 Rectal Cancer

Cui Tang; Jinming Xu; Moubin Lin et al.

Clinical Medicine Insights: Oncology, Vol. 18 · 2024 · English · DOAJ Scopus

Background: Distant metastasis is the leading cause of death in patients with rectal cancer. This study aims to comprehensively analyze the risk factors of distant metastasis in T3 T4 rectal cancer using magnetic resonance imaging (MRI), pathological features, and serum indicators. Methods: The…

PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy

Chenbo Zhang; Ajian Li; Huaguang Li et al.

Mediators of Inflammation, Vol. 2015 · 2015 · English · DOAJ Scopus

Aim. To investigate the correlation between PPP1R12A gene copy number and clinical outcomes of oxaliplatin-based regimen in stage III colorectal cancer (CRC). Methods. A total of 139 paraffin-embedded tissue samples of stage III CRC patients who received oxaliplatin-based treatment after radical…

Positive feedback between ROS and cis-axis of PIASxα/p38α-SUMOylation/MK2 facilitates gastric cancer metastasis

Qian Wang; Ci Xu; Qiang Fan et al.

Cell Death and Disease, Vol. 12 No. 11 · 2021 · English · DOAJ Scopus

Abstract MAPK/p38 is an important mammalian signaling cascade that responds to a variety of intracellular or extracellular stimuli, such as reactive oxygen species (ROS), and participates in numerous physiological and pathological processes. However, the biological function of p38 in different…

The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer

Junyi Ju; Hui Zhang; Moubin Lin et al.

Journal of Clinical Investigation · 2024 · English · OpenAlex Scopus

Lactylation has been recently identified as a new type of posttranslational modification occurring widely on lysine residues of both histone and nonhistone proteins. The acetyltransferase p300 is thought to mediate protein lactylation, yet the cellular concentration of the proposed lactyl-donor…

Also available at: DOAJ

Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice

Zhenxiong Ye; Wenfeng Lu; Lei Liang et al.

Stem Cell Research & Therapy, Vol. 10 No. 1 · 2019 · English · DOAJ Scopus

Abstract Background Mesenchymal stem cells (MSCs) can migrate to tissue injury sites where they can induce multipotential differentiation and anti-inflammation effects to treat tissue injury. When traditional therapeutic methods do not work, MSCs are considered to be one of the best candidates for…

Identification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury

Jiayin Peng; Fei Li; Jia Wang et al.

Cell Discovery, Vol. 8 No. 1 · 2022 · English · DOAJ Scopus

Abstract In adults, hepatocytes are mainly replenished from the existing progenitor pools of hepatocytes and cholangiocytes during chronic liver injury. However, it is unclear whether other cell types in addition to classical hepatocytes and cholangiocytes contribute to hepatocyte regeneration…

An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

Hui Zhang; Moubin Lin; Chao Dong et al.

Advanced Science, Vol. 8 No. 17 · 2021 · English · DOAJ Scopus

Abstract Elevated Wnt/β‐catenin signaling has been commonly associated with tumorigenesis especially colorectal cancer (CRC). Here, an MST4‐pβ‐cateninThr40 signaling axis essential for intestinal stem cell (ISC) homeostasis and CRC development is uncovered. In response to Wnt3a stimulation, the…

Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ–stimulated antitumor immunity

Jiale Ren; Ni Li; Siyu Pei et al.

The Journal of Clinical Investigation, Vol. 132 No. 8 · 2022 · English · DOAJ Scopus

IFN-γ–stimulated MHC class I (MHC-I) antigen presentation underlies the core of antitumor immunity. However, sustained IFN-γ signaling also enhances the programmed death ligand 1 (PD-L1) checkpoint pathway to dampen antitumor immunity. It remains unclear how these opposing effects of IFN-γ are…