14 hasil untuk "Roshell Muir"

Pathway to Medicine and Health Programs Revisited: Outcomes and Institutional Adaptations in Greater Philadelphia and Beyond

Dara Bright; Sarah Hughes; Roshell Muir

Education Sciences, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

This scoping literature review examines the outcomes and institutional adaptations of pathway programs designed to increase diversity in medical and allied health professions. These programs address systemic barriers faced by students from underrepresented (UR) backgrounds through a targeted focus…

Faculty belonging may be more important than we realize

Jaspal Singh; Roshell Muir; Yasmain Rice-Greene dkk.

Canadian Medical Education Journal, Vol. 16 No. 3 · 2025 · Prancis · DOAJ

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Adenosine deaminase-1 delineates human follicular helper T cell function and is altered with HIV

Virginie Tardif; Roshell Muir; Rafael Cubas dkk.

Nature Communications, Vol. 10 No. 1 · 2019 · Inggris · DOAJ Scopus

Follicular helper T cells are critical in the generation of the antibody response. Here the authors show that adenosine deaminase is involved in the Tfh program and ensuring the provision of B cell help.

The evolution of character education in medicine

Julie K. Silver; Amber Brooks; Suzanne C. Danhauer dkk.

Medical Education Online, Vol. 31 No. 1 · 2026 · Inggris · DOAJ Scopus

Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity

Jennifer Connors; Gina Cusimano; Nathan Mege dkk.

Human Vaccines & Immunotherapeutics, Vol. 19 No. 3 · 2023 · Inggris · DOAJ Scopus

In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors. Significant progress has been made in understanding the innate immune…

A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells

Margaret H. O’Connor; Roshell Muir; Marita Chakhtoura dkk.

Communications Biology, Vol. 4 No. 1 · 2021 · Inggris · DOAJ Scopus

Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in…

Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection

Roshell Muir; Talibah Metcalf; Virginie Tardif dkk.

PLOS Pathogens, Vol. 12 No. 7 · 2016 · Inggris · PLOS Scopus

The RV254 cohort of HIV-infected very early acute (4thG stage 1 and 2) (stage 1/2) and late acute (4thG stage 3) (stage 3) individuals was used to study T helper- B cell responses in acute HIV infection and the impact of early antiretroviral treatment (ART) on T and B cell function. To investigate…

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Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques

Nichole R. Klatt; Courtney Broedlow; Jessica M. Osborn dkk.

npj Vaccines, Vol. 6 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract An effective vaccine to prevent HIV transmission has not yet been achieved. Modulation of the microbiome via probiotic therapy has been suggested to result in enhanced mucosal immunity. Here, we evaluated whether probiotic therapy could improve the immunogenicity and protective efficacy of…

Activation of CXCR3+ Tfh cells and B cells in lymph nodes during acute HIV-1 infection correlates with HIV-specific antibody development

Julie L. Mitchell; Supranee Buranapraditkun; Pierre Gantner dkk.

Journal of Virology, Vol. 99 No. 3 · 2025 · Inggris · DOAJ Scopus

ABSTRACT Lymph node T follicular helper (Tfh) cells and germinal center (GC) B cells are critical to generate potent antibodies but are rarely possible to study in humans. To understand how Tfh/GC B-cell interactions during acute HIV-1 infection (AHI) impact the generation of HIV-specific…

Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses

Roshell Muir; Talibah Metcalf; Slim Fourati dkk.

PLOS Neglected Tropical Diseases, Vol. 17 No. 7 · 2023 · Inggris · PLOS Scopus

Schistosomiasis is a disease caused by parasitic flatworms of the Schistosoma spp., and is increasingly recognized to alter the immune system, and the potential to respond to vaccines. The impact of endemic infections on protective immunity is critical to inform vaccination strategies globally. We…

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Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection

Julie L. Mitchell; Justin Pollara; Kenneth Dietze dkk.

The Journal of Clinical Investigation, Vol. 132 No. 1 · 2022 · Inggris · DOAJ Scopus

Early initiation of antiretroviral therapy (ART) in acute HIV infection (AHI) is effective at limiting seeding of the HIV viral reservoir, but little is known about how the resultant decreased antigen load affects long-term Ab development after ART. We report here that Env-specific plasma antibody…