17 hasil untuk "Shumin Cheng"
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Artikel Jurnal Teks lengkap
A Heuristic Attribute-Reduction Algorithm Based on Conditional Entropy for Incomplete Information Systems
With the continuous expansion of databases, the extraction of information has been an urgent research topic in many fields. As an effective method to remove redundant attributes, attribute reduction demonstrates extraordinary ability in simplifying information systems. This paper applies a novel…
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Artikel Jurnal Teks lengkap
Characterization of the anti-pathogenic, genomic and phenotypic properties of a Lacticaseibacillus rhamnosus VHProbi M14 isolate
A strain of lactic acid bacteria from cheese was isolated, that showed strong growth inhibitory effects on Streptococcus mutans. The API 50CH system and 16S rDNA sequencing verified that this was a novel strain, and was named Lacticaseibacillus rhamnosus VHProbi M14. The strain inhibited the growth…
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Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice
Abstract The main objective of this study was to investigate the potential probiotic properties of Lacticaseibacillus rhamnosus VHProbi®M15 (M15). This study examined the effects of M15 on sucralfate-induced constipation in a mouse model. The BALB/c mice were randomly divided into four groups: the…
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Research progress on dynamic hopping technology for network layer
Firstly, the basic concept of network layer hopping technology was introduced and the security threats it faced were given. Then, two type of models and communication methods of network layer hopping technology based on traditional networks and software-defined networks were given. And the network…
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High-density lipoprotein cholesterol and nuclear factor I A in type 2 diabetes and mild cognitive impairment: biomarkers and mechanistic insights
Introduction Type 2 diabetes (T2D) and mild cognitive impairment (MCI) are interrelated conditions that significantly impair quality of life. This study aimed to identify a feasible biomarker for assessing T2D-MCI risk and to evaluate a potential therapeutic strategy. Material and methods We…
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Using population-scale transcriptomic and genomic data to map 3′ UTR alternative polyadenylation quantitative trait loci
Summary: 3′ UTR alternative polyadenylation (APA) quantitative trait loci (3′aQTL) can explain approximately 16.1% of trait-associated non-coding variants and is largely distinct from other molecular QTLs. Here, we describe a bioinformatic protocol for identifying 3′aQTLs through standard RNA-seq…
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Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study
Abstract There is an emergent need to develop functional cosmetic ingredients for the topical management of skin barrier function. This study aimed to investigate the efficacy of a lotion containing fermented lysates VHProbi® Mix R for enhancing the skin barrier. In vitro studies demonstrated that…
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Hsa_Circ_0105596/FTO inhibits progression of Parkinson's disease by sponging miR-187-3p and regulating eEF2
Background: Parkinson's disease (PD) characterized by inflammation and protein erroneous deposition, whose pathological mechanisms have not been elucidated. NcRNA plays important role in PD, especially when circRNA sponges miRNA, which leads to the breakdown of downstream regulation. The aim of…
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Inducible nitric oxide synthase accelerates nonalcoholic fatty liver disease progression by regulating macrophage autophagy
Abstract Background Cells and tissues, such as macrophages, express inducible nitric oxide synthase (INOS) after stimulation by certain factors. INOS helps mediate the macrophage inflammatory reaction, but few studies have explored how INOS affects macrophage function in nonalcoholic fatty liver…
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A cyclic adenosine monophosphate response element-binding protein inhibitor enhances the antibacterial activity of polymyxin B by inhibiting the ATP hydrolyzation activity of CrrB
The emergence of polymyxin B (PB) resistant Gram-negative bacteria poses an important clinical and public health threat. Antibiotic adjuvants development is a complementary strategy that fills the gap in new antibiotics. Here, we described the discovery of the enhancement capacity of compound…
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An exploration of GuaLouQuMaiWan related novel prognostic model and search for potential compound pachymic acid in bladder cancer
ObjectiveBladder cancer (BC) is a highly prevalent malignant tumor. The traditional Chinese medicine formula Guo Lou Qu Mai Wan (GLQMW), when used in conjunction with chemotherapy, has been shown to reduce adverse reactions and prolong survival time, although its specific mechanisms remain unclear…
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Establishment and characterization of a sigmoid colon cancer organoid with spinal metastasis
BackgroundSigmoid colon cancer with spinal metastases is rare in distant metastasis. In addition, the prognosis of colon cancer patients with spinal metastases is extremely poor. In order to find effective therapeutic agents, we need to know the biological characteristics of such patients from…
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Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study
Multidrug resistance (MDR) is a serious problem during cancer therapy. The purpose of the present study was to formulate D-α-Tocopheryl polyethylene glycol 1000 succinate-resveratrol-solid lipid nanoparticles (TPGS-Res-SLNs) to improve its therapeutic efficacy against breast cancer. In this study…
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Inducible nitric oxide synthase regulates macrophage polarization via the MAPK signals in concanavalin A‐induced hepatitis
Abstract Introduction Acute liver inflammatory reactions contribute to many health problems; thus, it is critical to understand the underlying pathogenic mechanisms of acute hepatitis. In this study, an experimental in vivo model of concanavalin A (ConA)‐induced hepatitis was used. Materials and…
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Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome
Abstract Sjögren's syndrome (SjS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to dry eyes and mouth. While previous genome‐wide association studies (GWAS) and transcriptomic analyses have identified genes associated with SjS, predictive…
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A multi-omic analysis reveals a predictive value of tertiary lymphoid structures in improving the prognosis of colorectal cancer patients with BRAF mutation
BackgroundBRAF mutations are prevalent in colorectal cancer (CRC) and generally confer a poor prognosis. Tertiary lymphoid structures (TLS), a critical component of the tumor immune microenvironment, exist in various malignancies and often correlate with improved immunotherapy response and…