14 hasil untuk "Tiansong Xu"
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Artikel Jurnal
Oral microbiomes: more and more importance in oral cavity and whole body
ABSTRACT Microbes appear in every corner of human life, and microbes affect every aspect of human life. The human oral cavity contains a number of different habitats. Synergy and interaction of variable oral microorganisms help human body against invasion of undesirable stimulation outside…
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Artikel Jurnal
Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity
The oral-systemic connection, salivary microbiome, and healthy longevity are increasingly recognized as biologically interconnected. This review summarizes lifespan changes in the salivary microbiome, its links to age-related systemic diseases, and recent progress in salivary MicroAge modeling. It…
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Artikel Jurnal
Specific cell subclusters of dental pulp stem cells respond to distinct pathogens through the ROS pathway
IntroductionMicrobial pathogens invade various human organs, including the oral cavity. Candida albicans (C.a) and Streptococcus mutans (S.m) served respectively as representative oral pathogenic fungi and bacteria to stimulate dental pulp stem cells (DPSCs) and to screen the DPSC subcluster that…
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Artikel Jurnal Teks lengkap
Midpalatal Suture: Single-Cell RNA-Seq Reveals Intramembrane Ossification and Piezo2 Chondrogenic Mesenchymal Cell Involvement
The midpalatal suture is mainly responsible for the growth and development of the maxillary and resistance to rapid maxillary expansion (RME). It is essential for clinical researchers to explore the intramembrane ossification and to elucidate the underlying mechanism of the maturation and…
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Artikel Jurnal
Single-cell atlas of dental pulp stem cells exposed to the oral bacteria Porphyromonas gingivalis and Enterococcus faecalis
Introduction:Porphyromonas gingivalis and Enterococcus faecalis promote the development of pulpitis and periapical periodontitis. These bacteria are difficult to eliminate from the root canal systems, leading to persistent infection and poor treatment outcomes. We explored the response of human…
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Artikel Jurnal Teks lengkap
Effect of STX5 on the metastasis of hepatocellular carcinoma and its mechanism
Objective To investigate the effect of STX5 on the metastasis of hepatocellular carcinoma (HCC) and its mechanism. Methods Clinical data were collected from 36 patients who were diagnosed with HCC in our hospital from January to December 2015, and the correlation between the expression level of…
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Artikel Jurnal
Impacts of Delivery Mode and Maternal Factors on Neonatal Oral Microbiota
ObjectivesInitial oral microbial colonization has complicatedly interacted with growth and development. The aim of our study was to discover links between oral microbiota community structure and mode of delivery, maternal factors, such as systemic diseases, abortion history, and pregnancy…
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Artikel Jurnal
Pulpitis as a microbial disease: single-cell insights into host responses and diagnostic biomarkers for vital pulp therapy
Background Pulpitis is a common dental disease driven by complex microbial infections, yet its microbial origins, diversity, and pathogenic mechanisms remain incompletely understood. A major clinical challenge is the absence of objective biological criteria to assess the severity and reversibility…
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Artikel Jurnal
Dextran sulfate sodium-induced colitis exacerbates periodontitis via the NADPH oxidase 2/reactive oxygen species axis in M1-like macrophages
Periodontitis is associated with various systemic diseases, among the most important of which is inflammatory bowel disease (IBD). However, the mechanisms by which IBD exacerbates periodontitis remain unclear. Activation of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2…
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Artikel Jurnal
CHAC2-mediated glutathione metabolic reprogramming drives N1 polarization of bone marrow neutrophils and exacerbates inflammatory comorbidities
Abstract The proinflammatory (N1) polarization of bone marrow (BM) neutrophils, driven by central immune remodeling in response to peripheral inflammation, plays a critical role in propagating localized inflammatory conditions, such as periodontitis, to systemic levels. Although this process…
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Artikel Jurnal
Oral virome metagenomic catalog links Porphyromonas gingivalis phages to obesity and type 2 diabetes
Summary: The human microbiota has a critical role in maintaining human microbiome homeostasis and health, yet the viral component of the oral microbiome remains largely unidentified. We establish the Human Oral Virome Database (HOVD) catalog, a freely accessible online resource cataloging 24,440…