133 hasil untuk "Anqi Lin"
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Artikel Jurnal Teks lengkap
Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer
Colorectal cancer (CRC) patients, especially those with deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) tumors, whose sensitivity to immune checkpoint inhibitors (ICIs) is significantly higher than that of patients with microsatellite-stable (MSS)/microsatellite…
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The effect of dietary oxidation balance scores and volatile organic compounds exposures on inflammation
Background: Inflammation is a significant factor in adverse health outcomes, but the combined effects of diets with varying oxidation levels and exposure to volatile organic compounds (VOCs) on inflammation are not well understood. This study aimed to elucidate the effects of the recognized Dietary…
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ChemProps: A RESTful API enabled database for composite polymer name standardization
Abstract The inconsistency of polymer indexing caused by the lack of uniformity in expression of polymer names is a major challenge for widespread use of polymer related data resources and limits broad application of materials informatics for innovation in broad classes of polymer science and…
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Effect of NCOR1 Mutations on Immune Microenvironment and Efficacy of Immune Checkpoint Inhibitors in Patient with Bladder Cancer
Immune checkpoint blockade (ICB) therapy has significantly progressed the treatment of bladder cancer (BLCA). Multiple studies have suggested that specific genetic mutations may serve as immune biomarkers for ICB therapy. Additionally, the nuclear receptor corepressor 1 (NCOR1) gene is a new player…
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Mutations Status of Chemokine Signaling Pathway Predict Prognosis of Immune Checkpoint Inhibitors in Colon Adenocarcinoma
In recent years, tumor immunotherapy has become an important treatment program and popular research focus. However, the use of immune checkpoint inhibitors (ICI) in the treatment of colorectal cancer still has limitations due to the current markers only being able to predict the prognosis of a…
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Nanomedicine strategies for ameliorating cancer by targeting immunosenescence: From challenge to opportunity
Immunosenescence represents a natural process of immune degeneration that occurs with aging. Although this process is a common phenomenon in elderly patients, it extremely gets involved in tumor development and affects the clinical efficacy of cancer immunotherapy. Emerging studies demonstrate that…
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Digestive System Toxicities of Immune Checkpoint Inhibitors: Mechanisms and Clinical Implications
Immune checkpoint inhibitors (ICIs) have achieved remarkable efficacy in treating malignancies but may simultaneously induce immune-related adverse events (irAEs), among which ICI-related digestive system adverse events (ir-DSAEs) occur with relatively high frequency and present severe clinical…
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Association of cannabis use with depression among cancer patients
The rate of cannabis use by cancer patients is climbing. However, as the risk of mental illness caused by cannabis use in cancer patients has not been effectively evaluated, this study will analyze the association between cannabis use and depression in cancer patients. This study collected data…
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An MIU-based deep embedded clustering model for urban functional zoning from remote sensing images and VGI data
Urban functional zoning offers valuable insights into urban morphology and sustainable development. However, the conventional fixed spatial units, such as blocks and grids, cannot easily capture the morphological characteristics inherent in functional union and separation during urban evolution. In…
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Climate change weakened the productivity benefits from the forestry ecological engineering projects-induced greening in China
To enhance ecosystem functioning and terrestrial carbon sink capacity, the Chinese government has implemented a series of regional ecological projects. However, the effectiveness of ecological projects varies considerably due to regional climate differences and diverse implementation strategies…
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Identifying core driving factors of urban land use change from global land cover products and POI data using the random forest method
Rapid urbanization at the expense of the environment led to a reduction in vegetation cover, and consequently aggravated land degradation, urban water logging, heat island effect and other effects. Revealing the driving mechanism behind urban land use change facilitates deeper insight into the…
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Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations
Abstract Immunotherapy has been incorporated into the first- and second-line treatment strategies for non-small cell lung cancer (NSCLC), profoundly ushering in a new treatment landscape. However, both adaptive signaling and oncogenic (epidermal growth factor receptor (EGFR)-driven) signaling may…
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A comparison of the efficacy of antiangiogenic agents combined with chemotherapy for the treatment of non-small cell lung cancer: a network meta-analysis
Abstract Objection To explore the effects of combinations of antiangiogenic agents and chemotherapy agents on non-small cell lung cancer (NSCLC) patients and indirectly compare the therapeutic effect of Endostar combined with chemotherapy and bevacizumab combined with chemotherapy on NSCLC. Methods…
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MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding…
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Artikel Jurnal Teks lengkap
Interpretable Prediction and Analysis of PVA Hydrogel Mechanical Behavior Using Machine Learning
Polyvinyl alcohol (PVA) hydrogels have emerged as versatile materials due to their exceptional biocompatibility and tunable mechanical properties, showing great promise for flexible sensors, smart wound dressings, and tissue engineering applications. However, rational design remains challenging due…
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Comprehensive Analysis Identifies PI3K/Akt Pathway Alternations as an Immune-Related Prognostic Biomarker in Colon Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitor Treatment
Introduction. In recent years, immune checkpoint inhibitors (ICIs) have attracted widespread attention and made breakthroughs in progress towards the treatment of various cancers. However, ICI therapy is selective, and its effects on many patients are not ideal. It is therefore critical to identify…