18 hasil untuk "Fanjun Cheng"

Neutrophil extracellular trap-related genes in PTCL: identification, prognosis and drug interaction prediction via bioinformatics-machine learning

Jing Chen; Fanjun Cheng; Jun Fang

Hematology, Vol. 31 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective: This study aimed to identify neutrophil extracellular trap-related genes (NET-RGs), explore their prognostic significance, and predict drug interactions in peripheral T-cell lymphoma (PTCL).Methods: Differentially expressed NET-RGs (DE-NRGs) between PTCL and normal tissues were screened…

Bioinformatic-based genetic characterizations of neural regulation in skin cutaneous melanoma

Fengdi Wang; Fanjun Cheng; Fang Zheng

Frontiers in Oncology, Vol. 13 · 2023 · Inggris · DOAJ Scopus

BackgroundRecent discoveries uncovered the complex cancer–nerve interactions in several cancer types including skin cutaneous melanoma (SKCM). However, the genetic characterization of neural regulation in SKCM is unclear.MethodsTranscriptomic expression data were collected from the TCGA and GTEx…

Treatment-Free Remission in Chronic Myeloid Leukemia and New Approaches by Targeting Leukemia Stem Cells

Yilin Chen; Jing Zou; Fanjun Cheng dkk.

Frontiers in Oncology, Vol. 11 · 2021 · Inggris · DOAJ Scopus

The therapeutic landscape for chronic myeloid leukemia (CML) has improved significantly with the approval of tyrosine kinase inhibitors (TKIs) for therapeutic use. Most patients with optimal responses to TKIs can have a normal life expectancy. Treatment-free remission (TFR) after discontinuing TKI…

Epstein-Barr virus: biology, pathogenesis and therapy of lymphomas

Jing Chen; Shan Zhang; Yi Zhao dkk.

Discover Oncology, Vol. 16 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Epstein-Barr virus (EBV) remains dormant in host B cells for a long time, and more than 90% of patients are asymptomatically infected. However, some internal factors (such as immune deficiency) or exogenous factors (such as HIV infection, inflammation and hypoxia) can destroy this…

Factors associated with the incidence and the expenditure of self-medication among middle-aged and older adults in China: A cross-sectional study

Yuxin Liu; Zehao Zheng; Xiubo Wang dkk.

Frontiers in Public Health, Vol. 11 · 2023 · Inggris · DOAJ Scopus

BackgroundWith the accelerated ageing of population and the growing prevalence of various chronic diseases in China, self-medication plays an increasingly important role in complementing the health care system due to its convenience and economy.ObjectiveThis study aimed to investigate the incidence…

Successful treatment discontinuation in CML patients with full-dose and low-dose TKI: Results from real-world practice

Yilin Chen; Huifang Zhao; Jingming Guo dkk.

Frontiers in Pharmacology, Vol. 14 · 2023 · Inggris · DOAJ Scopus

Background: In clinical studies, some patients who achieve deep molecular response (DMR) can successfully discontinue tyrosine kinase inhibitor (TKI). TKI dose reduction is also an important aspect of alleviating adverse effects and improving quality of life. This study aimed to explore the outcome…

Low-dose tyrosine kinase inhibitors in patients with chronic myeloid leukemia: a retrospective study in China

Yilin Chen; Zelin Liu; Jing Zou dkk.

Haematologica, Vol. 107 No. 8 · 2022 · Inggris · DOAJ Scopus

ACSL1 promotes imatinib-induced chronic myeloid leukemia cell senescence by regulating SIRT1/p53/p21 pathway

Wen Liu; Xiaoying Zhu; Ling Tang dkk.

Scientific Reports, Vol. 12 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Although tyrosine kinase inhibitors (TKIs) improve the prognosis of chronic myeloid leukemia (CML) patients, resistance to TKIs and residual leukemia stem cells (LSCs) inevitably become the bottleneck of cure. Therefore, we need to explore novel treatment strategies based on conventional…

Rare Variants in Inborn Errors of Immunity Genes Associated With Covid-19 Severity

Panhong Liu; Mingyan Fang; Yuxue Luo dkk.

Frontiers in Cellular and Infection Microbiology, Vol. 12 · 2022 · Inggris · DOAJ Scopus

Host genetic factors have been shown to play an important role in SARS-CoV-2 infection and the course of Covid-19 disease. The genetic contributions of common variants influencing Covid-19 susceptibility and severity have been extensively studied in diverse populations. However, the studies of rare…

Changes in the medical-seeking pattern and daily behavior of hematopoietic stem-cell transplant recipients during the COVID-19 epidemic: An online survey in Hubei Province, China

Rong Xie; Yicheng Zhang; Zhiping Huang dkk.

Frontiers in Public Health, Vol. 10 · 2022 · Inggris · DOAJ Scopus

BackgroundTo curb the spread of the coronavirus disease 2019 (COVID-19) epidemic, the Chinese government shut down Wuhan city from January 23rd to April 8th, 2020. The COVID-19 epidemic not only leads to widespread illness but also affects the diagnosis and treatment of hematopoietic stem-cell…

Prevalence and associated factors for workplace violence among general practitioners in China: a national cross-sectional study

Jing Feng; Zihui Lei; Shijiao Yan dkk.

Human Resources for Health, Vol. 20 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Background General practitioners (GPs) were at risk of violence in their everyday working lives. Workplace violence (WPV) among GPs is a global public health concern. This study aimed to investigate the prevalence and factors associated with WPV among GPs in China. Methods A…

Integrating plasma cell‐free DNA with clinical laboratory results enhances the prediction of critically ill patients with COVID‐19 at hospital admission

Yong Bai; Fang Zheng; Tongda Zhang dkk.

Clinical and Translational Medicine, Vol. 12 No. 7 · 2022 · Inggris · DOAJ Scopus

Fragmentomics of plasma mitochondrial and nuclear DNA inform prognosis in COVID-19 patients with critical symptoms

Haiqiang Zhang; Lingguo Li; Yuxue Luo dkk.

BMC Medical Genomics, Vol. 17 No. 1 · 2024 · Inggris · DOAJ Scopus

Abstract Background The mortality rate of COVID-19 patients with critical symptoms is reported to be 40.5%. Early identification of patients with poor progression in the critical cohort is essential to timely clinical intervention and reduction of mortality. Although older age, chronic diseases…

Quality‐of‐life, mental health, and perspective on TKI dose reduction as a prelude to discontinuation in chronic phase chronic myeloid leukemia

Yilin Chen; Na Xu; Yunfan Yang dkk.

Cancer Medicine, Vol. 12 No. 16 · 2023 · Inggris · DOAJ Scopus

Abstract Background Treatment‐free remission (TFR) has become the main target for chronic myeloid leukemia (CML). Tyrosine kinase inhibitors (TKI) dose optimization is crucial in managing adverse events, and improving adherence in clinical practice. In persons achieving a deep molecular response…

A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severity

Huanhuan Zhu; Fang Zheng; Linxuan Li dkk.

iScience, Vol. 24 No. 10 · 2021 · Inggris · DOAJ Scopus

Summary: The COVID-19 pandemic has caused over 220 million infections and 4.5 million deaths worldwide. Current risk factor cannot fully explain the diversity in disease severity. Here, we present a comprehensive analysis of a broad range of patients' laboratory and clinical assessments to…

Genome-wide association study of COVID-19 severity among the Chinese population

Yuanfeng Li; Yuehua Ke; Xinyi Xia dkk.

Cell Discovery, Vol. 7 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). The development of COVID-19 may be the result of a complex interaction between the microbial, environmental, and host genetic components. To…

Transcriptional Start Site Coverage Analysis in Plasma Cell-Free DNA Reveals Disease Severity and Tissue Specificity of COVID-19 Patients

Xinping Chen; Tao Wu; Lingguo Li dkk.

Frontiers in Genetics, Vol. 12 · 2021 · Inggris · DOAJ Scopus

Symptoms of coronavirus disease 2019 (COVID-19) range from asymptomatic to severe pneumonia and death. A deep understanding of the variation of biological characteristics in severe COVID-19 patients is crucial for the detection of individuals at high risk of critical condition for the clinical…

Trans-ethnic genome-wide association study of severe COVID-19

Peng Wu; Lin Ding; Xiaodong Li dkk.

Communications Biology, Vol. 4 No. 1 · 2021 · Inggris · DOAJ Scopus

Chaolong Wang and colleagues report a large genome-wide association study for COVID-19 severity in Chinese individuals. By meta-analysis with European data, they identify 3 loci associated with severe disease that suggest key roles for the adaptive immune system and the ABO blood group system in…