37 hasil untuk "Lin-Lin Bu"
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Artikel Jurnal Teks lengkap
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway
In a recent study published in Science , Tsvetkov et al 1 . shed a light on a new form of cell death, copper-dependent cell death (termed cuproptosis). They defined “cuproptosis” as a nonapoptotic cell death pathway. They have demonstrated that copper directly binds to lipoylated components of the…
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Advancing Health Equity and Policy through Integrative Global Ecological Analysis with Multidisciplinary Databases
Global public databases now contain extensive information about disease, environment, and society, but much of these data have been used only for descriptive summaries rather than for exploring deeper causes of health differences between countries. This commentary discusses how combining data from…
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Metal-dependent cell death resistance contribute to lymph node metastasis of oral squamous cell carcinoma
ObjectivesFerroptosis and cuproptosis can be summarized as metal-dependent cell death. This study aimed to explore the expression of metal-dependent cell death resistance (MCDR) characteristics in tumor cells of oral squamous cell carcinoma (OSCC) and to explore its relationship with lymph node…
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Artikel Jurnal Teks lengkap
Identification of SEC61G as a Diagnostic and Prognostic Biomarker in Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is a heterogeneous malignancy originating from the oral mucosal epithelium. Detecting novel biomarkers can offer crucial information on disease aggressiveness and expected clinical outcomes for individual patients. SEC61G, an aberrantly expressed gene in various…
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Mandibular Reconstruction With the Contralateral Vascularized Iliac Flap Using Individual Design: Iliac Crest Used to Reconstruct the Ramus and the Anterior Border of the Iliac Wing Used to Reconstruct the Inferior Border: A Case Report
Mandible defects resulting from resection of benign or malignant lesions, trauma, or radionecrosis are commonly encountered in the oral and maxillofacial department. Vascularized bone flaps, in general, provide the best functional and aesthetic outcome. The iliac crest provides a large piece of…
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Cell Membrane-Coated Nanoparticles for Dental, Oral, and Craniofacial Diseases
Dental, oral, and craniofacial diseases can substantially impact the quality of human life, thereby posing a serious public health concern. Although conventional therapies such as surgery have solved these problems largely, the prognosis of patients is not always satisfactory. Cell membrane-coated…
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Charting new frontiers: Co-inhibitory immune checkpoint proteins in therapeutics, biomarkers, and drug delivery systems in cancer care
Cancer remains a major health concern globally. Immune checkpoint inhibitors (ICIs) target co-inhibitory immune checkpoint molecules and have received approval for treating malignancies like melanoma and non-small cell lung cancer. While CTLA-4 and PD-1/PD-L1 are extensively researched, additional…
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Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy
Abstract Cancer immunotherapy is a novel therapeutic regimen because of the specificity and durability of immune modulations to treat cancers. Current cancer immunotherapy is limited by some barriers such as poor response rate, low tumor specificity and systemic toxicities. Porous nanomaterials…
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Lymph node metastasis in oral squamous cell carcinoma: Where we are and where we are going
Abstract Background Oral cancer is a common malignant tumour in the head and neck region, with over 90% of cases being oral squamous cell carcinoma (OSCC). Lymph node metastasis (LNM) is a significant adverse prognostic factor in OSCC; however, the mechanism of LNM in OSCC remains unclear, while…
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Multi-omics in immunotherapy research for HNSCC: present situation and future perspectives
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, significantly impacting patient survival and quality of life. The recent emergence of immunotherapy has provided new hope for HNSCC patients, improving survival rates; however, only 15%–20% of patients…
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Artikel Jurnal
Triaptosis and Cancer: Next Hope?
Cancer persists as one of the most formidable global public health crises and socioeconomic burdens of our era, compelling the scientific community to develop innovative and diversified therapeutic modalities to revolutionize clinical management and enhance patient outcomes. The recent seminal…
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Radiation-induced MYB reduction unleashes TIM-3 expression in NK cells to attenuate antitumor immunity in colorectal cancer
Abstract Background Colorectal cancer (CRC), the third most common cancer globally, presents challenges like metastasis, recurrence, and therapy resistance. Natural Killer (NK) cells are vital for anti-tumor immunity but become dysfunctional in the tumor microenvironment (TME). This study explored…
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Comparative analysis of GoPro and digital cameras in head and neck flap harvesting surgery video documentation: an innovative and efficient method for surgical education
Abstract Background An urgent need exists for innovative surgical video recording techniques in head and neck reconstructive surgeries, particularly in low- and middle-income countries where a surge in surgical procedures necessitates more skilled surgeons. This demand, significantly intensified by…
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Targeting phosphorylation of STAT3 delays tumor growth in HPV-negative anal squamous cell carcinoma mouse model
Abstract Although conventional chemoradiotherapy is effective for most anal squamous cell carcinoma (ASCC) patients, HPV-negative ASCC patients respond poorly to this treatment and new therapeutic approach is required. Our group has previously established an HPV-negative ASCC mouse model and…
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Gelatinase-sensitive nanoparticles loaded with photosensitizer and STAT3 inhibitor for cancer photothermal therapy and immunotherapy
Abstract Matrix metalloproteinase (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance the invasion and metastatic of tumor cells, and are associated with poor outcome of head and neck squamous cell carcinomas (HNSCCs). In the present work, MMPs-degradable…
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Synergistic nanozyme-macrophage hybrid system for targeted therapy of acute lung injury
Due to its complex pathogenesis involving dysregulated reactive oxygen species (ROS) storms, cytokine hyperactivation and immune cell infiltration, acute lung injury (ALI) presents critical clinical challenges, and conventional therapies often fail to address the dual requirements of precise…