25 hasil untuk "Linlin Wan"
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Artikel Jurnal
Research on CORE Paper Association Discovery and Semantic Services Based on Semantic Similarity
[Purpose/significance] This paper dissects the process and services of article association discovery in Connecting Repositories, and hopes to provide powerful reference for the recommendation and semantic linking of the content of articles in Chinese open access repositories. [Method/process] This…
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Artikel Jurnal
Third-generation versus first-generation EGFR tyrosine kinase inhibitors in Asian patients with advanced EGFR mutant non-small cell lung cancer: a meta-analysis of randomized controlled trials
Abstract Background Third-generation EGFR-TKIs (TGETs) have demonstrated improved clinical outcomes compared to first-generation EGFR-TKIs (FGETs) in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). Nonetheless, the comparative safety and efficacy of TGETs as a first-line option for…
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Artikel Jurnal
Analysis of the Brain Protective Effect of Flow Percentage Cerebral Perfusion Combined With Unilateral Antegrade Selective Cerebral Perfusion in Acute Aortic Dissection Arch Reconstruction Surgery
Background: To evaluate the neuroprotective efficacy of combining unilateral antegrade selective cerebral perfusion with percentage-controlled flow regulation during aortic arch reconstruction surgery for aortic dissection. Methods: A retrospective analysis was conducted using clinical data from…
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Artikel Jurnal
Serum vitamin levels in multiple system atrophy: A case-control study
AimThere is increasing evidence suggesting that vitamins may play important roles in the pathogenesis of multiple system atrophy (MSA). The purpose of this study was to detect the changes of serum vitamin levels and investigate their correlation with disease severity in MSA patients.MethodsIn this…
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Artikel Jurnal
Multidimensional biomarkers for multiple system atrophy: an update and future directions
Abstract Multiple system atrophy (MSA) is a fatal progressive neurodegenerative disease. Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and monitoring of disease-modifying therapies. In recent years, significant…
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Artikel Jurnal
Comparison of outcomes between axillary and femoral artery cannulation for type A aortic dissection surgery
Abstract Objective To compare the application and outcomes of femoral versus axillary arterial cannulation in adult patients undergoing surgery for type A aortic dissection. Methods We conducted a retrospective review of 108 patients who underwent surgery for type A aortic dissection, dividing them…
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Artikel Jurnal
Hypolipidemic effect of Fragarianilgerrensis Schlecht. medicine compound on hyperlipidemic rats
Abstract Background Fragarianilgerrensis Schlecht. medicine compound (FN-MC) is a kind of Chinese herbs’ compound consisted of Fragarianilgerrensis Schlecht. and Centella asiatica (L.) Urban. The study was to investigate the hypolipidemia effect of FN-MC in a hypolipidemic rat model. Methods Male…
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Artikel Jurnal
Attention-enhanced dilated convolution for Parkinson’s disease detection using transcranial sonography
Abstract Background Transcranial sonography (TCS) plays a crucial role in diagnosing Parkinson's disease. However, the intricate nature of TCS pathological features, the lack of consistent diagnostic criteria, and the dependence on physicians' expertise can hinder accurate diagnosis. Current…
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Artikel Jurnal
Lactylation and human disease
Abstract Background Lactylation, a new epigenetic modification, is an important way in which lactate exerts physiological functions. There is a close relationship between increased lactylations caused by lactate and glycolysis, which can interact and play a role in disease through lactate as an…
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Artikel Jurnal
MR Imaging of SCA3/MJD
Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a progressive autosomal dominantly inherited cerebellar ataxia characterized by the aggregation of polyglutamine-expanded protein within neuronal nuclei in the brain, which can lead to brain damage that precedes the onset of…
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Artikel Jurnal
The characteristic and biomarker value of transcranial sonography in cerebellar ataxia
Abstract Objective Transcranial sonography (TCS) is a noninvasive neuroimaging technique, visualizing deep brain structures and the ventricular system. Although widely employed in diagnosing various movement disorders, such as Parkinson's disease and dystonia, by detecting disease‐specific…
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Artikel Jurnal
Roles of Post-translational Modifications in Spinocerebellar Ataxias
Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, etc., of proteins can modulate protein properties such as intracellular distribution, activity, stability, aggregation, and interactions. Therefore, PTMs are vital regulatory mechanisms for…
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Artikel Jurnal
VR-based quantitative oculomotor analysis and association with regional brain atrophy in MSA
Background The quantitative assessment of the oculomotor system has emerged as a promising biomarker for neurodegenerative disorders. Although oculomotor impairments are commonly observed in multiple system atrophy (MSA) patients, the specific abnormalities and underlying neural structural changes…
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Artikel Jurnal
Alterations of the skin microbiome in multiple system atrophy: a pilot study
Abstract Multiple system atrophy (MSA) alters skin physiology, potentially impacting skin microbiota. This pilot study investigated whether skin microbiota differs in MSA and whether these differences relate to disease severity. Using 16S rRNA sequencing of cervical and axillary sites in MSA…
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Artikel Jurnal
Tri-modal assessment reveals early visual pathway degeneration in patients with MSA-C
Background and objectives: Post-mortem evidence suggests neurodegeneration in the visual pathway in multiple system atrophy-cerebellar type (MSA-C), yet robust in vivo evidence remains scarce. This study aimed to characterize these visual pathway changes in MSA-C patients by integrating optical…
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Artikel Jurnal
Erythropoiesis–inosine metabolic axis failure underlying retinal neurodegeneration in glaucoma: novel diagnoses and therapies
Abstract Glaucoma, long considered an ocular-limited, age-dependent and hypoxia-driven neurodegeneration, is here reframed as a systemic erythroid–inosine axis failure that originates in the bone marrow yet culminates in retinal ganglion cell (RGC) death. By mining UK Biobank datasets (n = 127,028)…
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Artikel Jurnal
Inosine promotes erythrocyte metabolic reprogramming and restores oxygen release for rejuvenation via 2,3-BPG-PNP axis
Abstract Aging-related diseases are aggravated by tissue hypoxia; however, the underlying mechanism remains unknown. Here, we report that the oxygen (O2) release capacity of red blood cells (RBCs) gradually decreases with age and is closely associated with aging-related tissue dysfunction…
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Artikel Jurnal
The genetic landscape and phenotypic spectrum of GAA-FGF14 ataxia in China: a large cohort studyResearch in context
Summary: Background: An intronic GAA repeat expansion in FGF14 was recently identified as a cause of GAA-FGF14 ataxia. We aimed to characterise the frequency and phenotypic profile of GAA-FGF14 ataxia in a large Chinese ataxia cohort. Methods: A total of 1216 patients that included 399 typical…
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Artikel Jurnal
CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells
Abstract Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a progressive autosomal dominant neurodegenerative disease caused by abnormal CAG repeats in the exon 10 of ATXN3. The accumulation of the mutant ataxin-3 proteins carrying expanded polyglutamine (polyQ) leads to selective…