21 results for "Yaobin LIN"
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Journal Article
Primary hepatopancreatobiliary lymphoma: epidemiology, clinical features, and treatment outcomes
Abstract Differences in the epidemiology, clinical features, and treatment strategies of primary lymphomas of the liver, pancreas, and biliary system (primary hepatopancreatobiliary lymphomas [PHPBL]) remain unclear. We compared the clinical characteristics of patients with lymphomas of these organ…
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Journal Article
Mendelian randomization analysis reveals the causal relationship between immune cells and leukemia
Abstract Background Increasing evidence indicates certain types of immune cells are linked to leukemia, but whether this link is causal has remained unclear. Methods A two-sample Mendelian randomization (MR) analysis was conducted to examine the causal relationship (CR) among 731 immune cell traits…
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Journal Article
Postoperative locoregional recurrence pattern and treatment management of stage pT4 sigmoid colon cancer: a retrospective cohort study
Abstract Background This study aimed to explore the pattern of locoregional recurrence after surgery in patients with non-metastatic stage pT4 sigmoid colon cancer and the role of adjuvant radiotherapy on survival. Methods We retrospectively analyzed data from 208 patients who underwent surgery in…
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Journal Article
Comprehensive transcriptomics and proteome analysis to identify prognostic risk factors for MYCN non-amplified high-risk neuroblastoma
Abstract Background MYCN non-amplified (MYCN-NA) neuroblastoma (NB) demonstrates considerable heterogeneity in both biological and clinical aspects, and its molecular and biological characteristics remain inadequately defined. Methods A comprehensive multi-omics analysis was performed on…
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Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung Cancer
Lung cancer remains the most frequently diagnosed cancer and the leading cause of cancer-related death worldwide, with anaplastic lymphoma kinase (ALK) fusion mutations accounting for approximately 4%-9% of cases. In recent years, there are increasing clinical evidences suggesting that the…
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Journal Article
Impact of treatment on the prognosis of childhood in hepatoblastoma: A SEER based analysis
Background: The prognosis of patients with hepatoblastoma has been unsatisfactory. This study analyzed the effects of different treatment methods on cancer-specific survival (CSS) in children with hepatoblastoma. Method: From 2000 to 2018, patients with hepatoblastoma were included in the…
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Journal Article
Comprehensive 18F-FDG PET-based radiomics in elevating the pathological response to neoadjuvant immunochemotherapy for resectable stage III non-small-cell lung cancer: A pilot study
PurposeTo develop a comprehensive PET radiomics model to predict the pathological response after neoadjuvant toripalimab with chemotherapy in resectable stage III non-small-cell lung cancer (NSCLC) patients.MethodsStage III NSCLC patients who received three cycles of neoadjuvant toripalimab with…
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Journal Article
ZC3H18 regulates alternative splicing and related genes in cervical cancer
IntroductionAlternative splicing (AS) and RNA-binding proteins (RBPs) have been implicated in various diseases. However, a comprehensive understanding of their role in RNA metabolism, progression, and metastasis in cervical cancer remains elusive. This study aimed to identify the potential effect…
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Journal Article
Role of a lipid metabolism-related lncRNA signature in risk stratification and immune microenvironment for colon cancer
Abstract Background Energy metabolism disorder, especially lipid metabolism disorder, is an important biological characteristic of colon cancer. This research sought to examine the association between lipid metabolism-related long non-coding RNAs (lncRNAs) and prognoses among colon cancer patients…
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Journal Article
Progress in Immunotherapy for Pulmonary Lymphoepithelioma Carcinoma
Pulmonary lymphoepithelioma carcinoma (PLEC), a rare non-small cell lung cancer subtype strongly associated with Epstein-Barr virus (EBV) infection, currently lacks a standardized treatment regimen. Conventional platinum-based systemic chemoradiotherapy remains the primary approach. In recent…
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Journal Article
Metastasis pattern and prognosis in children with neuroblastoma
Abstract Background We aimed to investigate the different metastases and prognoses of neuroblastoma (NB) and determine the risk factors of metastasis. Method Data of 1224 patients with NB were obtained from the Surveillance, Epidemiology and End Results database (2010–2018). Pearson’s chi-square…
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Journal Article
Prognostic analysis and beneficiary identification of adjuvant external beam radiotherapy for stage pT4b sigmoid colon cancer
Abstract The clinical efficacy of adjuvant radiotherapy in sigmoid colon cancer remains questioned. To evaluate the clinical efficacy of adjuvant external beam radiotherapy (EBRT) for patients with pathologic stage T4b sigmoid colon cancer. Patients with stage pT4b sigmoid colon cancer receiving…
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Journal Article
Identifying the long-term survival beneficiary of chemotherapy for stage N1c sigmoid colon cancer
Abstract Sigmoid colon cancer often has an unsatisfactory prognosis. This study explored the effect of tumor deposits (TDs) on survival, and whether their presence/absence influence individualized treatment. Data of postoperative patients with sigmoid colon cancer were extracted from the…
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Journal Article
A novel diagnostic model for predicting immune microenvironment subclass based on costimulatory molecules in lung squamous carcinoma
There is still no ideal predictive biomarker for immunotherapy response among patients with non-small cell lung cancer. Costimulatory molecules play a role in anti-tumor immune response. Hence, they can be a potential biomarker for immunotherapy response. The current study comprehensively…
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Journal Article
Efficacy of Neoadjuvant Immunochemotherapy in Pulmonary Lymphoepithelioma Carcinoma Compared With Lung Squamous Cell Carcinoma and Adenocarcinoma: A Retrospective Cohort Study
ABSTRACT Objective Immunotherapy has emerged as a promising treatment for patients with pulmonary lymphoepithelioma carcinoma (PLEC). This study aimed to evaluate the efficacy and safety of neoadjuvant immunochemotherapy in patients with PLEC. Methods Clinical stage IB‐III patients with PLEC who…
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Journal Article
Safety and necessity of omitting mediastinal lymph node dissection in cN0/N1 non-small cell lung cancer after neoadjuvant immunotherapy
BackgroundLymph nodes are crucial for perioperative immunotherapy but have to be completely resected in surgery. Trials evaluating the safety and necessity of omitting systemic mediastinal lymph node (mLN) dissection in non-small cell lung cancer (NSCLC) are still absent.MethodscN0/N1 NSCLC…
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Journal Article
Dynamics of peripheral blood inflammatory index predict tumor pathological response and survival among patients with locally advanced non-small cell lung cancer who underwent neoadjuvant immunochemotherapy: a multi-cohort retrospective study
BackgroundStatic tumor features before initiating anti-tumor treatment were insufficient to distinguish responding from non-responding tumors under the selective pressure of immuno-therapy. Herein we investigated the longitudinal dynamics of peripheral blood inflammatory indexes (dPBI) and its…
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Journal Article
Radiotherapy in addition to systemic therapy reduces the early mortality of angioimmunoblastic T-cell lymphoma
Abstract Angioimmunoblastic T-cell lymphoma (AITL) is a rare and aggressive peripheral T-cell lymphoma that is prone to early progression and recurrence and has a poor overall prognosis. Notably, early mortality (EM) and risk factors for AITL are currently unclear. We performed a retrospective…
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Journal Article
Risk stratification and prognosis prediction based on inflammation‐related gene signature in lung squamous carcinoma
Abstract Background Inflammation is known to have an intricate relationship with tumorigenesis and tumor progression while it is also closely related to tumor immune microenvironment. Whereas the role of inflammation‐related genes (IRGs) in lung squamous carcinoma (LUSC) is barely understood…
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Journal Article
Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer
Abstract Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage non‐small‐cell lung cancer (NSCLC), but it has not consistently yielded durable responses. Biomarkers for the prediction of efficacy are warranted…