26 results for "Fu-Rong Li"
Showing 1–20 · 0.35 seconds · RSS
-
Journal Article
Influence of hypertension duration and blood pressure levels on cardiovascular disease and all-cause mortality: A large prospective cohort study
Background and objectsA longer duration of hypertension (HTN) has been suggested to be associated with a greater risk of cardiovascular disease (CVD). Whether such an association is similar for mortality risk, and whether HTN duration is associated with CVD/mortality beyond blood pressure (BP)…
-
Journal Article
Shift work and risk of incident gastroesophageal reflux disease: the association and mediation
IntroductionShift work has become an increasingly common work mode globally. This study aimed to investigate the association between shift work and the risk of incident gastroesophageal reflux disease (GORD), an upward gastrointestinal disorder disease worldwide, and to explore the mediating…
-
Journal Article
Long-Term Visit-To-Visit Blood Pressure Variability and Risk of Diabetes Mellitus in Chinese Population: A Retrospective Population-Based Study
Objectives: To examine the association between visit-to-visit blood pressure variability (BPV) and incident diabetes mellitus (DM) risk in a Chinese population.Methods: Data comes from China Health and Nutrition Survey (n = 15,084). BPV was estimated as the average real variability (ARV) using at…
-
Journal Article Full text
Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Analysis of ACCORD Trial
Background Obesity is associated with adverse health events among diabetic patients, however, the relationship between obesity fluctuation and risk of microvascular complications among this specific population is unclear. We aimed to examine the effect of waist circumference (WC) and body mass…
-
Journal Article
Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults
Background: Epidemiological evidence regarding the associations between long-term exposure to air pollution and risk of incident inflammatory bowel disease (IBD) is scant. Objectives: We examined the associations of various specific air pollutants with the risk of incident ulcerative colitis and…
-
Journal Article
Association between secondhand smoke exposure, maternal smoking during pregnancy, and stroke incidence in nonsmokers
Background: To evaluate the independent and combined associations of secondhand smoke (SHS) exposure and maternal smoking during pregnancy with the risk of total stroke and its subtypes, including ischemic and hemorrhagic stroke, among nonsmokers. Objectives: To investigate the independent and…
-
Journal Article
Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality
Background To evaluate the sex‐specific associations of total and regional fat/muscle mass ratio (FMR) with cardiovascular disease (CVD) incidence and mortality, and to explore the underlying mechanisms driven by cardiometabolites and inflammatory cells. We compared the predictive value of FMRs to…
-
Journal Article
Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure
Lipoprotein(a) (Lp(a)) is a largely genetically determined biomarker for cardiovascular disease (CVD), while its potential interplay with family history (FHx) of CVD, a measure of both genetic and environmental exposures, remains unclear. We examined the associations of Lp(a) in terms of…
-
Journal Article
控制糖尿病心血管风险的行动(ACCORD)试验中的血脂变异性和微血管并发症风险:一项事后分析
Abstract Background Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of lipid variability on the risk of diabetic microvascular outcomes among type 2 diabetes mellitus patients. Methods We assessed the association between…
-
Journal Article
The potential adverse effects of hypodermic glucagon‐like peptide ‐1 receptor agonist on patients with type 2 diabetes: A population‐based study
Abstract Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs), a class of injectable antidiabetic drugs, have shown significant efficacies in improving glycemic and weight control in patients with type 2 diabetes (T2D). However, the long‐term safety of GLP‐1 RAs remains insufficiently…
-
Journal Article
Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
Abstract Background Deep understanding the differentiation process of human embryonic stem cells (hESCs) is essential for developing cell-based therapeutic strategy. Substantial efforts have been made to investigate protein-coding genes, yet it remains lacking comprehensive characterization of long…
-
Journal Article
Prevalence and associated factors of sexually transmitted infections among methamphetamine users in Eastern China: a cross-sectional study
Abstract Background The reported incidence of sexually transmitted infections (STIs) in China has been increasing over the last decades, especially among drug users, which has become one of the main burdens of public health in China. This study was conducted to estimate the prevalence and…
-
Journal Article
Proteomic analysis reveals LRPAP1 as a key player in the micropapillary pattern metastasis of lung adenocarcinoma
Objectives: Lung adenocarcinomas have different prognoses depending on their histological growth patterns. Micropapillary growth within lung adenocarcinoma, particularly metastasis, is related to dismal prognostic outcome. Metastasis accounts for a major factor leading to mortality among lung…
-
Journal Article
Integrative analysis reveals a lineage-specific circular RNA landscape for adipo-osteogenesis of human mesenchymal stem cells
Abstract Background The balance between osteogenesis and adipogenesis of mesenchymal stem cells (MSCs) is critical to skeletal development and diseases. As a research hotspot, circular RNAs (circRNAs) have expanded our understanding of a hidden layer of the transcriptome. Yet, their roles during…
-
Journal Article
Zinc‐Organometallic Framework Vaccine Controlled‐Release Zn2+ Regulates Tumor Extracellular Matrix Degradation Potentiate Efficacy of Immunotherapy
Abstract Tumor extracellular matrix (ECM) not only forms a physical barrier for T cells infiltration, but also regulates multiple immunosuppressive pathways, which is an important reason for immunotherapy failure. The cyclic guanosine monophosphate‐adenosine monophosphate synthase‐stimulator of…
-
Journal Article
Menopausal characteristics and hormone replacement therapy in relation to long-term risk of cholecystectomy in women
BackgroundWomen are known to be at higher risk for gallbladder disease than men, suggesting a role of female hormones in the pathogenesis of gallbladder disease. This study aimed to assess menopausal characteristics, hormone replacement therapy (HRT) and their joint effect on long-term risk of…
-
Journal Article
Diabetes duration, glycemic control, and risk of stroke and stroke subtypes: a nationwide prospective cohort study
Abstract To evaluate the relationship of diabetes duration and glycemic control with risk of stroke and its major subtypes using data from the UK Biobank, a large population-based cohort of UK adults. We included 23,401 UK adult residents with diabetes who had no known stroke at baseline…
-
Journal Article
午睡与2型糖尿病风险之间的关联受到炎症和肥胖的调节:来自英国生物样本库(UK‐Biobank) 435 342名参与者的证据
Abstract Background Existing evidence concerning the relationship between daytime napping and type 2 diabetes (T2D) is inconsistent, and whether the effects of napping differ by body fat percentage (BFP) and C‐reactive protein (CRP) is unclear. We aimed to investigate the association between…
-
Journal Article
在中国非糖尿病或糖尿病患者中，用不同的方法评估肾小球滤过率和全因死亡率的风险:一项全国性的前瞻性研究
Abstract Background Whether estimated glomerular filtration rates (eGFRs) by differing biomarkers are differentially associated with mortality or whether the associations differ by diabetes status remains unclear, especially in Chinese population. Methods We included 6995 participants without…