19 hasil untuk "Chuang-Rung Chang"
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Artikel Jurnal
The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae
Mitochondria are essential organelles that form a dynamic network within cells. The fusion, fission, and transport processes among mitochondria must reach a balance, which is achieved through complex regulatory mechanisms. These dynamic processes and regulatory pathways are highly conserved across…
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Artikel Jurnal Teks lengkap
Changes in Energy Status of Saccharomyces cerevisiae Cells during Dehydration and Rehydration
Anhydrobiosis is the state of life when cells are exposed to waterless conditions and gradually cease their metabolism. In this study, we determined the sequence of events in Saccharomyces cerevisiae energy metabolism during processes of dehydration and rehydration. The intensities of respiration…
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Phosphorylation of the fission protein Drp1 contributes to the impact of the curcuminoid 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one on mitochondrial and cellular processes
Curcumin and its curcuminoid derivatives extracted from turmeric have been investigated for their potential therapeutic benefits in cancer treatment. Curcuminoids 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one and bisdemethoxycurcumin can be obtained from Alpinia galangal. Despite their similar…
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Artikel Jurnal
Translating peripheral blood biomarkers into Alzheimer’s disease care: an exploratory dual-pathway model of immune and viral dynamics in behavioral and psychological symptoms of dementia
BackgroundBehavioral and psychological symptoms of dementia (BPSD) critically complicate Alzheimer’s disease care, yet the precise biological correlates for highly heterogeneous symptom domains remain largely unexplored.ObjectiveTo investigate an exploratory “dual-pathway framework” to map how…
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Artikel Jurnal Teks lengkap
Resveratrol Modulates Mitochondria Dynamics in Replicative Senescent Yeast Cells
Mitochondria form a reticulum network dynamically fuse and divide in the cell. The balance between mitochondria fusion and fission is correlated to the shape, activity and integrity of these pivotal organelles. Resveratrol is a polyphenol antioxidant that can extend life span in yeast and worm…
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Artikel Jurnal
Srv2 Is a Pro-fission Factor that Modulates Yeast Mitochondrial Morphology and Respiration by Regulating Actin Assembly
Summary: Dynamic processes such as fusion, fission, and trafficking are important in the regulation of cellular organelles, with an abundant literature focused on mitochondria. Mitochondrial dynamics not only help shape its network within cells but also are involved in the modulation of respiration…
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A change of PD-1/PD-L1 expression on peripheral T cell subsets correlates with the different stages of Alzheimer's Disease
Abstract Background Immune checkpoints are a set of costimulatory and inhibitory molecules that maintain self-tolerance and regulate immune homeostasis. The expression of immune checkpoints on T cells in malignancy, chronic inflammation, and neurodegenerative diseases has gained increasing…
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Artikel Jurnal
Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213
Abstract Background Androgen receptor (AR) plays important role in the development, progression, and metastasis of prostate cancer (PCa). Caffeic acid phenethyl ester (CAPE) is the main component of honey bee propolis. We determined if CAPE affects the signaling and stability of AR in PCa cells…
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Artikel Jurnal
Soft X-ray tomography analysis of mitochondria dynamics in Saccharomyces cerevisiae
Abstract Background Mitochondria are highly dynamic organelles that constantly undergo processes of fission and fusion. The changes in mitochondrial dynamics shape the organellar morphology and influence cellular activity regulation. Soft X-ray tomography (SXT) allows for three-dimensional imaging…
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Artikel Jurnal
DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axis
Abnormal DRP1 expression has been identified in a variety of human cancers. However, the prognostic potential and mechanistic role of DRP1 in head and neck cancer (HNC) are currently poorly understood. Here, we demonstrated a significant upregulation of DRP1 in HNC tissues, and that DRP1 expression…
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Artikel Jurnal
Identification of distinct slow mode of reversible adaptation of pancreatic ductal adenocarcinoma to the prolonged acidic pH microenvironment
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with high metastatic potential and poor clinical outcome. Like other solid tumors, PDAC in the early stages is often asymptomatic, and grows very slowly under a distinct acidic pHe (extracellular pH)…
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Artikel Jurnal
Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model
ABSTRACT DNA vaccines offer advantages such as low production cost, rapid manufacturing, and enhanced stability for transport and storage, making them suitable for addressing tropical and emerging infectious diseases. However, their limited immunogenicity in humans often necessitates multiple…
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Artikel Jurnal
A comprehensive study of Z-DNA density and its evolutionary implications in birds
Abstract Background Z-DNA, a left-handed helical form of DNA, plays a significant role in genomic stability and gene regulation. Its formation, associated with high GC content and repetitive sequences, is linked to genomic instability, potentially leading to large-scale deletions and contributing…
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Artikel Jurnal
Exploration of influenza A virus PA protein-associated cellular proteins discloses its impact on mitochondrial function
Influenza A virus can infect respiratory tracts and may cause severe illness in humans. Proteins encoded by influenza A virus can interact with cellular factors and dysregulate host biological processes to support viral replication and cause pathogenicity. The influenza viral PA protein is not only…
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Artikel Jurnal
Filamentous chemokine CCL5 structure and the functional aspects
Abstract Human inflammation-related CC chemokine ligand 5 (hCCL5) has significant self-assembly property under physiological conditions. The mechanism and function of hCCL5 oligomerization remain unclear. Different intermolecular interactions, such as E66-K25 or E66-R44/K45, have been reported to…
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Artikel Jurnal
Identification of chicken-derived antibodies targeting the Candida albicans Als3 protein
Abstract Candida albicans is a major opportunistic pathogen, responsible for nearly half of clinical candidemia cases. The rising prevalence of azole-resistant Candida species represents a significant clinical challenge, underscoring the urgent need for alternative therapeutic strategies…
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Artikel Jurnal
Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression
Abstract Background Long-term consumption of an excessive fat and sucrose diet (Western diet, WD) has been considered a risk factor for metabolic syndrome (MS) and cardiovascular disease. Caveolae and caveolin-1 (CAV-1) proteins are involved in lipid transport and metabolism. However, studies…