25 hasil untuk "Refik Pul"

A narrative review on the safety of glatiramer acetate in multiple sclerosis: focus on Europe

Refik Pul; Jelena Skuljec; Santosh B. Shirol dkk.

Therapeutic Advances in Chronic Disease, Vol. 16 · 2025 · Inggris · DOAJ Scopus

Glatiramer acetate (GA) has been a pivotal therapy for relapsing multiple sclerosis (MS) due to its favorable safety profile. Long-term data spanning decades demonstrate its continued use in diverse patient populations. Adverse events include manageable localized injection site reactions…

Immunotherapies in chronic adhesive arachnoiditis - A case series and literature review

Jana Hackert; Louisa Maßmann; Ulrich Sure dkk.

eNeurologicalSci, Vol. 24 · 2021 · Inggris · DOAJ Scopus

Chronic spinal adhesive arachnoiditis (CSAA) is a rare condition with limited therapeutic options. Surgical treatment proves effective in approximately 60% of cases. Conservative treatment options have not been extensively investigated. Here, we report the course of the disease, analyze the effect…

Glatiramer Acetate Increases Phagocytic Activity of Human Monocytes In Vitro and in Multiple Sclerosis Patients

Refik Pul; Franco Morbiducci; Jelena Škuljec dkk.

PLoS ONE, Vol. 7 No. 12 · 2012 · Inggris · PLOS Scopus

Beside its effects on T cells, a direct influence on cells of the myelo-monocytic lineage by GA becomes evident. Recently, we demonstrated that GA drives microglia to adopt properties of type II antigen presenting cells (APC) and increases their phagocytic activity. In the present work, we focused…

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Disease-modifying therapies for relapsing/active secondary progressive multiple sclerosis – a review of population-specific evidence from randomized clinical trials

Antonios Bayas; Monika Christ; Simon Faissner dkk.

Therapeutic Advances in Neurological Disorders, Vol. 16 · 2023 · Inggris · DOAJ Scopus

Although the understanding of secondary progressive multiple sclerosis (SPMS) is evolving, early detection of relapse-independent progression remains difficult. This is further complicated by superimposed relapses and compensatory mechanisms that allow for silent progression. The term relapsing…

Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?

Elke Verena Voß; Jelena Škuljec; Viktoria Gudi dkk.

Neurobiology of Disease, Vol. 45 No. 1 · 2012 · Inggris · DOAJ Scopus

Microglia play a key role in the initiation and perpetuation of de- and remyelination because of their ability to present antigens and clear cell debris by phagocytosis. Different factors expressed or secreted by microglia seem to play an important role in regenerative processes. But it remains…

Implications of COVID-19 Outbreak on Immune Therapies in Multiple Sclerosis Patients—Lessons Learned From SARS and MERS

Nora Möhn; Refik Pul; Christoph Kleinschnitz dkk.

Frontiers in Immunology, Vol. 11 · 2020 · Inggris · DOAJ Scopus

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic keeps the world in suspense. In addition to the fundamental challenges for the health care system, the individual departments must decide how to deal with patients at risk. Neurologists are confronted with the question, how they…

MOG antibody–associated encephalomyelitis mimicking bacterial meningomyelitis following ChAdOx1 nCoV-19 vaccination: a case report

Jordi Kühne Escolà; Cornelius Deuschl; Andreas Junker dkk.

Therapeutic Advances in Neurological Disorders, Vol. 15 · 2022 · Inggris · DOAJ Scopus

We report a case of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalomyelitis following vector-based vaccination against SARS-CoV-2 that mimicked bacterial meningomyelitis upon initial presentation. A 43-year-old woman who had received a first dose of ChAdOx1 nCoV-19…

Fumaric Acids Do Not Directly Influence Gene Expression of Neuroprotective Factors in Highly Purified Rodent Astrocytes

Kaweh Pars; Marina Gingele; Jessica Kronenberg dkk.

Brain Sciences, Vol. 9 No. 9 · 2019 · Inggris · DOAJ Scopus

(1) Background: Dimethylfumarate (DMF) has been approved for the treatment of relapsing remitting multiple sclerosis. However, the mode of action of DMF and its assumed active primary metabolite monomethylfumarate (MMF) is still not fully understood. Former reports suggest a neuroprotective effect…

Severe and long-lasting alteration of albumin redox state by plasmapheresis

Kristina Boss; Mark Stettner; Fabian Szepanowski dkk.

Scientific Reports, Vol. 12 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Plasmapheresis (PE) is an established form of therapeutic apheresis (TA). Purpose of this longitudinal prospective single center study was to investigate the effect of PE on albumin redox state (ARS), as infusion of commercial albumin during PE may alter albumin oxidation which has an…

Reorganization of the actin cytoskeleton during the formation of neutrophil extracellular traps (NETs)

Hans Georg Mannherz; Heidi Budde; Muhammad Jarkas dkk.

European Journal of Cell Biology, Vol. 103 No. 2 · 2024 · Inggris · DOAJ Scopus

We analyzed actin cytoskeleton alterations during NET extrusion by neutrophil-like dHL-60 cells and human neutrophils in the absence of DNase1 containing serum to avoid chromatin degradation and microfilament disassembly. NET-formation by dHL-60 cells and neutrophils was induced by Ionomycin or…

Analysis of Free Circulating Messenger Ribonucleic Acids in Serum Samples from Late-Onset Spinal Muscular Atrophy Patients Using nCounter NanoString Technology

Markus Leo; Linda-Isabell Schmitt; Fabian Mairinger dkk.

Cells, Vol. 12 No. 19 · 2023 · Inggris · DOAJ Scopus

5q-related Spinal muscular atrophy (SMA) is a hereditary multi-systemic disorder leading to progressive muscle atrophy and weakness caused by the degeneration of spinal motor neurons (MNs) in the ventral horn of the spinal cord. Three SMN-enhancing drugs for SMA treatment are available. However…

Varicella zoster virus infections in neurological patients: a clinical study

Thomas Skripuletz; Kaweh Pars; Alina Schulte dkk.

BMC Infectious Diseases, Vol. 18 No. 1 · 2018 · Inggris · DOAJ Scopus

Abstract Background Varicella zoster virus (VZV) reactivation is a common infectious disease in neurology and VZV the second most frequent virus detected in encephalitis. This study investigated characteristics of clinical and laboratory features in patients with VZV infection. Methods Two hundred…

Cognitive Impairment in Adult Patients with 5q-Associated Spinal Muscular Atrophy

Kathrin Kizina; Yakup Akkaya; Daniel Jokisch dkk.

Brain Sciences, Vol. 11 No. 9 · 2021 · Inggris · DOAJ Scopus

In previous studies, a below-average, average, or above-average intelligence quotient (IQ) in children with SMA was detected but, aside from a severe physical disability, the cognitive performance of adult SMA patients has not yet been evaluated. The intelligence test used in this study, the…

NfL predicts relapse-free progression in a longitudinal multiple sclerosis cohort study

Timo Uphaus; Falk Steffen; Muthuraman Muthuraman dkk.

EBioMedicine, Vol. 72 · 2021 · Inggris · DOAJ Scopus

Background: Easily accessible biomarkers enabling the identification of those patients with multiple sclerosis (MS) who will accumulate irreversible disability in the long term are essential to guide early therapeutic decisions. We here examine the utility of serum neurofilament light chain (sNfL)…

Immune Response to Seasonal Influenza Vaccination in Multiple Sclerosis Patients Receiving Cladribine

Leoni Rolfes; Steffen Pfeuffer; Jelena Skuljec dkk.

Cells, Vol. 12 No. 9 · 2023 · Inggris · DOAJ Scopus

Cladribine has been approved for the treatment of multiple sclerosis (MS) and its administration results in a long-lasting depletion of lymphocytes. As lymphopenia is known to hamper immune responses to vaccination, we evaluated the immunogenicity of the influenza vaccine in patients undergoing…

Kappa free light chain concentration in serum is reduced after CD20-depletion with ocrelizumab

Franz Felix Konen; Gudrun Mechthild Körner; Martin W. Hümmert dkk.

Neurological Research and Practice, Vol. 7 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Background Kappa free light chains (KFLC), a byproduct of immunoglobulin (Ig) synthesis by B-lineage cells, can serve as an indicator for inflammatory activity. In multiple sclerosis (MS), especially the intrathecal KFLC production has gained increasing importance as a biomarker for…

Switching from anti-CD20 therapies to cladribine and vice versa – Analysis of a German relapsing multiple sclerosis cohort

Franz Felix Konen; Steffen Pfeuffer; Konstantin Fritz Jendretzky dkk.

Neurotherapeutics, Vol. 23 No. 1 · 2026 · Inggris · DOAJ Scopus

Anti-CD20 antibodies and cladribine are established therapies for active relapsing multiple sclerosis (RMS). Increasing evidence suggests that switching between these therapies may be beneficial in patients with ongoing disease activity under current treatment. In this multicenter retrospective…

Absence of Regulatory T Cells Causes Phenotypic and Functional Switch in Murine Peritoneal Macrophages

Jelena Skuljec; Adan Chari Jirmo; Anika Habener dkk.

Frontiers in Immunology, Vol. 9 · 2018 · Inggris · DOAJ Scopus

Tissue macrophages are important components of tissue homeostasis and inflammatory pathologies. In the peritoneal cavity, resident macrophages interact with a variety of immune cells and can exhibit broad range of phenotypes and functions. Forkhead-box-P3 (FOXP3)+ regulatory T cells (Tregs) play an…

Management of disease-modifying therapies in multiple sclerosis and comorbid rheumatoid arthritis

Franz Felix Konen; Torsten Witte; Diana Ernst dkk.

Neurological Research and Practice, Vol. 7 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Background Comorbid autoimmune disorders, including rheumatoid arthritis (RA), are common in people with multiple sclerosis (MS). Both conditions share pathogenic similarities, enabling potential overlap in treatments. While numerous disease-modifying therapies (DMT) are approved for MS…