36 hasil untuk "Shiling Chen"

Two Decades of Therapeutic Trials in Supratentorial Intracerebral Haemorrhage: Lessons from Failure and Success

Xuan Wu; Shiling Chen; Zhouping Tang

Expert Reviews in Molecular Medicine, Vol. 28 · 2026 · Inggris · DOAJ Scopus

Abstract Background Spontaneous intracerebral hemorrhage (sICH) remains associated with high mortality and long-term disability worldwide. Since the publication of the Surgical Trial in Intracerebral Haemorrhage (STICH) in 2005, numerous randomized controlled trials have evaluated surgical…

Application of Small Molecules in the Central Nervous System Direct Neuronal Reprogramming

Jingyi Wang; Shiling Chen; Chao Pan dkk.

Frontiers in Bioengineering and Biotechnology, Vol. 10 · 2022 · Inggris · DOAJ Scopus

The lack of regenerative capacity of neurons leads to poor prognoses for some neurological disorders. The use of small molecules to directly reprogram somatic cells into neurons provides a new therapeutic strategy for neurological diseases. In this review, the mechanisms of action of different…

Non-syndromic premature ovarian insufficiency associated with monoallelic LIG4 mutation via haploinsufficiency

Sha Yu; Xingyu Zhou; Yunhui Lai dkk.

Journal of Ovarian Research, Vol. 19 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Background Premature ovarian insufficiency (POI) is a heterogeneous reproductive disorder, with genetic factors, particularly defects in DNA damage response pathways, increasingly implicated in its pathogenesis. DNA ligase IV (LIG4) is a key enzyme in the non-homologous end joining (NHEJ)…

Does current ovarian endometrioma increase the time for DOR patients to reach live birth in IVF?

Yu Deng; Zhanhui Ou; Minna Yin dkk.

BMC Pregnancy and Childbirth, Vol. 22 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Background The contents of ovarian endometrioma (OMA) such as inflammatory mediators, reactive oxygen species, and iron may disrupt normal folliculogenesis and result in subsequent oocyte apoptosis. Therefore, women with OMA have a potential risk of diminished ovarian reserve (DOR). The…

Inspiration for the treatment of intracerebral hemorrhage from the duality of glial scar: The right time point for reactive astrocytes reprogramming

Liyang Huang; Jingyi Wang; Shiling Chen dkk.

Brain Hemorrhages, Vol. 5 No. 3 · 2024 · Inggris · DOAJ Scopus

A novel heterozygous splice-altering mutation in HFM1 may be a cause of premature ovarian insufficiency

Jing Zhe; Shiling Chen; Xin Chen dkk.

Journal of Ovarian Research, Vol. 12 No. 1 · 2019 · Inggris · DOAJ Scopus

Abstract Background Premature ovarian insufficiency (POI) leads to early loss of ovarian function in women aged A) associated with POI was identified by whole-exome sequencing. This mutation was heterozygous in the affected family members and was absent in the unaffected family members. In silico…

Mapping Trends in Moyamoya Angiopathy Research: A 10-Year Bibliometric and Visualization-Based Analyses of the Web of Science Core Collection (WoSCC)

Danyang Chen; Ge Zhang; Jiahui Wang dkk.

Frontiers in Neurology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

Background: Moyamoya angiopathy (MMA), which includes moyamoya disease (MMD) and moyamoya syndrome (MMS), is an uncommon cerebrovascular condition characterized by recurrent stroke. We carried out a bibliometric analysis to examine the development of and research trends in MMA research.Methods…

Ngn2 failed to induce astrocyte-to-neuron reprogramming after intracerebral hemorrhage

Shiling Chen; Liyang Huang; Jingyi Wang dkk.

Brain Hemorrhages, Vol. 7 No. 5 · 2026 · Inggris · DOAJ Scopus

Objective: Intracerebral hemorrhage (ICH) is a severe neurological disorder with high mortality due to neuronal loss, and current therapies face significant challenges. Cell reprogramming offers a potential solution. This study explores whether Neurogenin2 (Ngn2) can reprogram astrocytes into…

Mechanism and application of immune interventions in intracerebral haemorrhage

Xiaoxiao Xu; Yuanwei Li; Shiling Chen dkk.

Expert Reviews in Molecular Medicine, Vol. 26 · 2024 · Inggris · DOAJ Scopus

Despite stroke being one of the major and increasing burdens to global health, therapeutic interventions in intracerebral haemorrhage (ICH) continue to be a challenge. Existing treatment methods, such as surgery and conservative treatment have shown limited efficacy in improving the prognosis of…

Intrauterine injection of bioengineered hydrogel loaded exosomes derived from HUCM stem cells and spermidine prominently augments the pregnancy rate in thin endometrium rats

Xiuying Lin; Yanqiu Fang; Xuguang Mi dkk.

Regenerative Therapy, Vol. 27 · 2024 · Inggris · DOAJ Scopus

The endometrium is essential to the development of embryos and pregnancy. Human umbilical cord mesenchymal stem cells (HUCMSCs) are promising stem cell sources. HUCMSCs self-renew quickly and are painless to collect. Spermidine is an inherent polyamine needed for cellular and molecular processes…

Reversal and resumption of anticoagulants in patients with anticoagulant-associated intracerebral hemorrhage

Jingfei Yang; Jie Jing; Shiling Chen dkk.

European Journal of Medical Research, Vol. 29 No. 1 · 2024 · Inggris · DOAJ Dikeluarkan Scopus 2024

Abstract The use of anticoagulants has become more frequent due to the progressive aging population and increased thromboembolic events. Consequently, the proportion of anticoagulant-associated intracerebral hemorrhage (AAICH) in stroke patients is gradually increasing. Compared with intracerebral…

Asiatic acid inhibits cervical cancer cell proliferation and migration via PI3K/AKT/mTOR signaling pathway

Xiuying Lin; Yanqiu Fang; Xuguang Mi dkk.

Heliyon, Vol. 10 No. 13 · 2024 · Inggris · DOAJ Scopus

Cervical cancer (CC) is a malignant tumor of the female reproductive system that typically occurs in cervical cells and has high incidence and mortality rates, strong metastatic ability, and poor prognosis. Asiatic acid (AA) exhibits anti-inflammatory, anti-depressant, and anti-tumor effects…

Neuroprotective effects of adipose‐derived stem cells on ferrous sulfate‐induced neurotoxicity

Qian Wu; Chao Pan; Yang Hu dkk.

Brain Science Advances, Vol. 7 · 2021 · Inggris · DOAJ

Background: Ferrous ion, a degradation product of hematomas, induces inflammatory reactions and other secondary injuries after intracerebral hemorrhage (ICH). Our study aimed to investigate the specific neuroprotective mechanism of adipose‐derived stem cells (ADSCs) on ferrous ion‐induced neural…

Dl-3-N-Butylphthalide Promotes Angiogenesis in an Optimized Model of Transient Ischemic Attack in C57BL/6 Mice

Jiahui Wang; Yanyan Li; Haihan Yu dkk.

Frontiers in Pharmacology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

Transient ischemic attack (TIA) has been widely regarded as a clinical entity. Even though magnetic resonance imaging (MRI) results of TIA patients are negative, potential neurovascular damage might be present, and may account for long-term cognitive impairment. Animal models that simulate human…

snRNA-seq reveals key transcription factors in the inflammatory response of microglia after intracerebral hemorrhage

Zhuojin Wu; Danyang Chen; Shiling Chen dkk.

Scientific Reports, Vol. 15 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Intracerebral hemorrhage (ICH) is a severe neurological disease with limited treatment options. Microglia, the primary immune cells of the brain, contribute significantly to secondary injury following ICH, exhibiting heterogeneity in response across different stages of ICH. However, the…

Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke

Luwei Nie; Dabao Yao; Shiling Chen dkk.

Cell Death Discovery, Vol. 9 No. 1 · 2023 · Inggris · DOAJ Scopus

Abstract Due to the limited capacity of the adult mammalian brain to self-repair and regenerate, neurological diseases, especially neurodegenerative disorders and stroke, characterized by irreversible cellular damage are often considered as refractory diseases. Neural stem cells (NSCs) play a…

Cell polarization in ischemic stroke: molecular mechanisms and advances

Yuanwei Li; Xiaoxiao Xu; Xuan Wu dkk.

Neural Regeneration Research, Vol. 20 No. 3 · 2025 · Inggris · DOAJ Scopus

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate…

Multi-sensor fusion and intelligent aspiration control of minimally invasive surgical robot for intracerebral hemorrhage

Ge Zhang; Shiling Chen; Zhuojin Wu dkk.

Brain Hemorrhages, Vol. 3 No. 1 · 2022 · Inggris · DOAJ Scopus

…University of Science and Technology, team led by Professor Dansheng Chen from School of Mechanical Engineering & Automation-BUAA, Beihang University and team led by engineer Wenjie Liu from Beijing WanTeFu Medical Instrument Co., Ltd to carry out fundamental investigations of micro-invasive…

Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders

Yunjie Li; Yangyang Feng; Xia Liu dkk.

Neural Regeneration Research, Vol. 21 No. 10 · 2026 · Inggris · DOAJ Scopus

Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive, portable, and ecologically valid manner, providing a unique insight into neurovascular coupling. However, functional imaging biomarkers with high…

Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency

Xiaofei Zhang; Linzi Ma; Xiaotong Liu dkk.

Materials Today Bio, Vol. 31 · 2025 · Inggris · DOAJ Scopus

Background: Premature ovarian insufficiency (POI) refers to the severe decline or failure of ovarian function in women younger than 40 years of age. It is a serious hazard to women's physical and mental health, but current treatment options are limited. Mesenchymal stem cell-derived exosomes…